Kallolika Mondal
YOU?
Author Swipe
View article: Pre-motor Mesenchymal stromal Cell Dysfunction Drives Immune Dysregulation in Parkinson’s Disease
Pre-motor Mesenchymal stromal Cell Dysfunction Drives Immune Dysregulation in Parkinson’s Disease Open
Parkinson's disease (PD) is characterized by chronic neuroinflammation and peripheral immune dysfunction, yet the mechanisms underlying systemic-immunomodulatory failure remain unclear. Here we demonstrate that mesenchymal stromal cell (MS…
View article: Intranasal delivery of DPSC-derived small extracellular vesicles-encased phloroglucinol attenuates non-motor and motor deficits and promotes neurogenesis in an in vivo rat model of Parkinson’s disease
Intranasal delivery of DPSC-derived small extracellular vesicles-encased phloroglucinol attenuates non-motor and motor deficits and promotes neurogenesis in an in vivo rat model of Parkinson’s disease Open
This study provides the first instance of using DPSC-derived sEV as a delivery vehicle for phloroglucinol in a PD model. sEV-Phl demonstrated significant neuroprotective-effects, enhanced DA-neuron survival and neurogenesis, and reduced ne…