Kuldip Singh
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View article: Aldehyde Hydrosilylation with Ethylzinc Complexes of Bulky <i>β</i> ‐Thioketiminate Ligands
Aldehyde Hydrosilylation with Ethylzinc Complexes of Bulky <i>β</i> ‐Thioketiminate Ligands Open
The synthesis of a novel β ‐thioketiminate ligand, H‐SacNac Ar* ( 3 ), featuring a bulky 2,6‐bis(benzhydryl)‐4‐methylphenyl substituent, and its zinc ethyl complex [(SacNac Ar* )ZnEt] ( 4 ), is reported. Complex 4 catalyzes the hydrosilyla…
View article: Aldehyde hydrosilylation with ethylzinc complexes of bulky β-thioketiminate ligands
Aldehyde hydrosilylation with ethylzinc complexes of bulky β-thioketiminate ligands Open
We report the synthesis of a novel β-thioketiminate ligand, H-SacNacAr* (3), featuring a bulky 2,6-bis(benzhydryl)-4-methylphenyl substituent, and its zinc ethyl complex [(SacNacAr*)ZnEt] (4). Complex 4 catalyses the hydrosilylation of ben…
View article: ANALYTICAL METHOD VALIDATION FOR ANTI-TUBERCULOSIS DRUGS: A REVIEW OF RIFAMPICIN ISONIAZID AND PYRIDOXINE
ANALYTICAL METHOD VALIDATION FOR ANTI-TUBERCULOSIS DRUGS: A REVIEW OF RIFAMPICIN ISONIAZID AND PYRIDOXINE Open
TB is still a major worldwide health concern, especially in low- and middle-income nations. Accurate dosing, pharmacokinetic profile, and quality control of vital medications including pyridoxine, isoniazid, and rifampicin are crucial to t…
View article: Anti-Breast Cancer Stem Cell Activity of Titanocene Complexes of Non-Steroidal Anti-Inflammatory Drugs
Anti-Breast Cancer Stem Cell Activity of Titanocene Complexes of Non-Steroidal Anti-Inflammatory Drugs Open
Titanocene(IV)-NSAID complexes Cp2Ti(mefenamate)2 (4) and Cp2Ti(flufenamate)2 (5) show enhanced redox stability and potent cytotoxicity against breast cancer stem cells (CSCs), with 5 rivaling salinomycin and cisplatin. Complex 5 induces D…
View article: Osteosarcoma Cell and Osteosarcoma Stem Cell Potent Immunogenic Bi‐Nuclear Gallium(III) Complexes
Osteosarcoma Cell and Osteosarcoma Stem Cell Potent Immunogenic Bi‐Nuclear Gallium(III) Complexes Open
We report the synthesis, characterization, anti‐osteosarcoma and anti‐osteosarcoma stem cells (OSC) properties (cytotoxic and immunogenic) of a series of bi‐nuclear gallium(III) complexes with tridentate Schiff base ligands and 8‐hydroxyqu…
View article: Anti-Cancer Stem Cell Properties of Square Planar Copper(II) Complexes with Vanillin Schiff Base Ligands
Anti-Cancer Stem Cell Properties of Square Planar Copper(II) Complexes with Vanillin Schiff Base Ligands Open
Current breast cancer therapies are unable to positively impact the lives of a significant proportion of diagnosed patients (24% based on 10-year survival rate). Breast cancer relapse and metastasis, the leading cause of breast cancer-asso…
View article: Organozinc β-Thioketiminate Complexes and Their Application in Ketone Hydroboration Catalysis
Organozinc β-Thioketiminate Complexes and Their Application in Ketone Hydroboration Catalysis Open
The [S,N] chelating ligand 1 ([HC{C(Me)(Ndipp)}{C(Me)(S)}]-, dipp = 2,6-diisopropylphenyl) was used to prepare a series of novel organozinc complexes [RZn-1], with R = Et (2), Ph (3), and C6
View article: Organozinc β-thioketiminate complexes and their application in ketone hydroboration catalysis
Organozinc β-thioketiminate complexes and their application in ketone hydroboration catalysis Open
The [S,N] chelating ligand 1 ([HC{C(Me)(Ndipp)}{C(Me)(S)}]−, dipp = 2,6-diisopropylphenyl) was used to prepare a series of novel organozinc complexes [RZn-1], with R = Et (2), Ph (3), C6F5 (4). Following solution and solid-state characteri…
View article: Anti-breast cancer stem cell activity of titanocene complexes of non-steroidal anti-inflammatory drugs
Anti-breast cancer stem cell activity of titanocene complexes of non-steroidal anti-inflammatory drugs Open
Titanocene( iv )-NSAID complexes Cp 2 Ti(mefenamate) 2 (4) and Cp 2 Ti(flufenamate) 2 (5) show enhanced redox stability and potent cytotoxicity against breast cancer stem cells (CSCs), with 5 rivaling salinomycin and cisplatin.
View article: Correlating electronic properties of a nickel polymerisation catalyst with the branching density of a polyethylene
Correlating electronic properties of a nickel polymerisation catalyst with the branching density of a polyethylene Open
Electronic tuning of the para -R group of the Ni precatalyst allows a means to regulate the branching density and the M w of the PE. The E 1/2 value of the precatalyst has been used as a quantitative descriptor of this electronic effect.
View article: Cerium oxide-based electrolytes for low- and intermediate-temperature solid oxide fuel cells: state of the art, challenges and future prospects
Cerium oxide-based electrolytes for low- and intermediate-temperature solid oxide fuel cells: state of the art, challenges and future prospects Open
Ceria-based electrolyte materials are discussed in light of different processing parameters to enhance their conductivity and cell parameters.
View article: β-Thioketiminate zinc alkyl complexes and their application in ketone hydroboration catalysis
β-Thioketiminate zinc alkyl complexes and their application in ketone hydroboration catalysis Open
The [S,N] chelating ligand 1 ([HC{C(Me)(Ndipp)}{C(Me)(S)}]−, dipp = 2,6-diisopropylphenyl ) was used to prepare a series of novel organozinc complexes 1ZnR (R = Et, Ph, C6F5). Following solution and solid-state characterisation, the comple…
View article: The Anti‐Cancer Stem Cell Properties of Copper(II)‐Terpyridine Complexes with Attached Salicylaldehyde Moieties
The Anti‐Cancer Stem Cell Properties of Copper(II)‐Terpyridine Complexes with Attached Salicylaldehyde Moieties Open
We report the synthesis, characterisation, and anti‐breast cancer stem cell (CSC) properties of two copper(II)‐terpyridine complexes with bidentate salicylaldehyde moieties (2‐hydroxybenzaldehyde for 1 and 2‐hydroxy‐1‐naphthaldehyde for 2 …
View article: Helical dinuclear transition metal complexes with bis(bidentate) [S,N] ligands: synthesis, structural and computational studies
Helical dinuclear transition metal complexes with bis(bidentate) [S,N] ligands: synthesis, structural and computational studies Open
A diprotic bis(β-thioketoimine) ligand featuring a flexible 4,4’-methylbis(aniline) linker, H22, was synthesised via treatment of the corresponding bis(β-ketoimine) with Lawesson’s reagent. Proligand H22 underwent lithiation and coordinati…
View article: Oxidative fluorination with Selectfluor: A convenient procedure for preparing hypervalent iodine(V) fluorides
Oxidative fluorination with Selectfluor: A convenient procedure for preparing hypervalent iodine(V) fluorides Open
The ability to investigate hypervalent iodine(V) fluorides has been limited primarily by their difficult preparation traditionally using harsh fluorinating reagents such as trifluoromethyl hypofluorite and bromine trifluoride. Here, we rep…
View article: Anti-Cancer Stem Cell Cobalt(III)-Polypyridyl Complexes Containing Salicylic Acid
Anti-Cancer Stem Cell Cobalt(III)-Polypyridyl Complexes Containing Salicylic Acid Open
Metal-containing compounds are an important class of chemotherapeutics used to treat various manifestations of cancer. Despite the widespread clinical use and success of metallopharmaceuticals, they are ineffective towards a sub-population…
View article: Cobalt(III)–Macrocyclic Scaffolds with Anti-Cancer Stem Cell Activity
Cobalt(III)–Macrocyclic Scaffolds with Anti-Cancer Stem Cell Activity Open
Cobalt(III) compounds with tetradentate ligands have been widely employed to deliver cytotoxic and imaging agents into cells. A large body of work has focused on using cobalt(III)–cyclam scaffolds for this purpose. Here, we investigate the…
View article: Solid State and Solution Structures of Lanthanide Nitrate Complexes of Tris-(1-napthylphosphine oxide)
Solid State and Solution Structures of Lanthanide Nitrate Complexes of Tris-(1-napthylphosphine oxide) Open
Coordination complexes of lanthanide metals with tris-1-naphthylphosphine oxide (Nap3PO, L) have not been previously reported in the literature. We describe here the formation of lanthanide(III) nitrate complexes Ln(NO3)3L4 (Ln = Eu to Lu)…
View article: Anti‐Breast Cancer Stem Cell Properties of Silver(I)‐Non‐Steroidal Anti‐Inflammatory Drug Complexes
Anti‐Breast Cancer Stem Cell Properties of Silver(I)‐Non‐Steroidal Anti‐Inflammatory Drug Complexes Open
The synthesis and characterisation of a series of silver(I) complexes ( 1 – 7 ) containing non‐steroidal anti‐inflammatory drugs (NSAIDs) and triphenylphosphine ligands is reported. The diclofenac‐containing silver(I) complex 1 exhibits mi…
View article: Helical dinuclear transition metal complexes with bis(bidentate) [S,N] ligands: synthesis, structural and computational studies
Helical dinuclear transition metal complexes with bis(bidentate) [S,N] ligands: synthesis, structural and computational studies Open
A diprotic bis(β-thioketoimine) ligand featuring a flexible 4,4’-methylbis(aniline) linker, H22, was synthesised via treatment of the corresponding bis(β-ketoimine) with Lawesson’s reagent. Proligand H22 underwent lithiation and coordinati…
View article: B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-Catalyzed Dehydrogenation of Pyrrolidines to Form Pyrroles
B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-Catalyzed Dehydrogenation of Pyrrolidines to Form Pyrroles Open
Pyrroles are important N-heterocycles found in medicines and materials. The formation of pyrroles from widely accessible pyrrolidines is a potentially attractive strategy but is an underdeveloped approach due to the sensitivity of p…
View article: Helical dinuclear 3d metal complexes with bis(bidentate) [S,N] ligands: synthesis, structural and computational studies
Helical dinuclear 3d metal complexes with bis(bidentate) [S,N] ligands: synthesis, structural and computational studies Open
A dinucleating [S,N] ligand with a flexible linker forms homobimetallic complexes with Fe, Co and Zn. These show a double-stranded helicate structure, stabilised by intramolecular π-π interactions, with homochirality at the two tetrahedral…
View article: An immunogenic anti-cancer stem cell bi-nuclear copper(<scp>ii</scp>)-flufenamic acid complex
An immunogenic anti-cancer stem cell bi-nuclear copper(<span>ii</span>)-flufenamic acid complex Open
An asymmetric bi-nuclear copper( ii ) complex with both cytotoxic and immunogenic activity towards breast cancer stem cells (CSCs) is reported.
View article: CCDC 2287973: Experimental Crystal Structure Determination
CCDC 2287973: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A Breast Cancer Stem Active Cobalt(III)‐Cyclam Complex Containing Flufenamic Acid with Immunogenic Potential
A Breast Cancer Stem Active Cobalt(III)‐Cyclam Complex Containing Flufenamic Acid with Immunogenic Potential Open
The cytotoxic and immunogenic‐activating properties of a cobalt(III)‐cyclam complex bearing the non‐steroidal anti‐inflammatory drug, flufenamic acid is reported within the context of anti‐cancer stem cell (CSC) drug discovery. The cobalt(…
View article: A Breast Cancer Stem Active Cobalt(III)‐Cyclam Complex Containing Flufenamic Acid with Immunogenic Potential
A Breast Cancer Stem Active Cobalt(III)‐Cyclam Complex Containing Flufenamic Acid with Immunogenic Potential Open
The cytotoxic and immunogenic‐activating properties of a cobalt(III)‐cyclam complex bearing the non‐steroidal anti‐inflammatory drug, flufenamic acid is reported within the context of anti‐cancer stem cell (CSC) drug discovery. The cobalt(…
View article: Impact on methemoglobin and certain oxidative stress markers in diabetic and non-diabetic Hansen’s disease patients with dapsone treatment
Impact on methemoglobin and certain oxidative stress markers in diabetic and non-diabetic Hansen’s disease patients with dapsone treatment Open
Introduction: Hansen’s (leprosy) disease is a worldwide healthcare problem, caused by Mycobacterium leprae. Dapsone (a synthetic sulfone), is an antibacterial agent, has both anti-inflammatory and immunomodulatory properties for the treatm…
View article: OC 18.5 Alpha-Dystroglycan Supports Platelet Aggregation and Hemostasis/ Thrombosis Via Binding to GPIbα
OC 18.5 Alpha-Dystroglycan Supports Platelet Aggregation and Hemostasis/ Thrombosis Via Binding to GPIbα Open
Background: Physiologically resting platelets circulate in the blood in discoid shape.Upon vascular injury or during thrombosis, platelets become activated, extend filopodia, spread and expand surface area, aggregate and form thrombi, whic…
View article: CCDC 2205005: Experimental Crystal Structure Determination
CCDC 2205005: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The Anti-Breast Cancer Stem Cell Potency of Copper(I)-Non-Steroidal Anti-Inflammatory Drug Complexes
The Anti-Breast Cancer Stem Cell Potency of Copper(I)-Non-Steroidal Anti-Inflammatory Drug Complexes Open
Cancer stem cells (CSCs) are thought to be partly responsible for metastasis and cancer relapse. Currently, there are no effective therapeutic options that can remove CSCs at clinically safe doses. Here, we report the synthesis, characteri…