Kamakshi Lakshminarayan
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View article: Associations of Stroke With Risk of Epilepsy: Results From the Atherosclerosis Risk in Communities (<scp>ARIC</scp>) Study
Associations of Stroke With Risk of Epilepsy: Results From the Atherosclerosis Risk in Communities (<span>ARIC</span>) Study Open
Objective To estimate the risk of epilepsy associated with stroke in a community‐based cohort, with consideration of stroke type, number, and severity. Methods Data from 15,100 Atherosclerosis Risk in Communities (ARIC) Study participants …
View article: Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study
Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study Open
Background and Aims Identifying lifestyle risk factors related to abnormal cardiac phenotypes, including structure and function, will be essential to prevent or slow down the progression to heart failure. Little is known about intakes of m…
View article: Assessment of the Modified Rankin Scale in Electronic Health Records with a Fine-tuned Large Language Model
Assessment of the Modified Rankin Scale in Electronic Health Records with a Fine-tuned Large Language Model Open
Introduction The modified Rankin scale (mRS) is an important metric in stroke research, often used as a primary outcome in clinical trials and observational studies. The mRS can be assessed retrospectively from electronic health records (E…
View article: Dietary Carbohydrate Quality Is Associated with Epigenetic Age Acceleration: a Cross-Sectional Study of the CARDIA Cohort
Dietary Carbohydrate Quality Is Associated with Epigenetic Age Acceleration: a Cross-Sectional Study of the CARDIA Cohort Open
View article: Population attributable fraction of total stroke associated with modifiable risk factors in the United States
Population attributable fraction of total stroke associated with modifiable risk factors in the United States Open
Stroke is a leading cause of death in the United States across all race/ethnicity and sex groups, though disparities exist. We investigated the potential for primary prevention of total first stroke for Americans aged 20 years or older, st…
View article: Deep terminal negative of the P wave in V1 and incidence of ischemic stroke: The atherosclerosis risk in communities (ARIC) study
Deep terminal negative of the P wave in V1 and incidence of ischemic stroke: The atherosclerosis risk in communities (ARIC) study Open
View article: Percutaneous left atrial appendage occlusion and risk of stroke, hospitalized bleeding and death in Medicare beneficiaries
Percutaneous left atrial appendage occlusion and risk of stroke, hospitalized bleeding and death in Medicare beneficiaries Open
Purpose Among patients with atrial fibrillation (AF), a nonpharmacologic option (e.g., percutaneous left atrial appendage occlusion [LAAO]) is needed for patients with oral anticoagulant (OAC) contraindications. Among beneficiaries in the …
View article: Sex-specific racial and ethnic variations in short-term outcomes among patients with first or recurrent ischemic stroke: Paul Coverdell National Acute Stroke Program, 2016-2020
Sex-specific racial and ethnic variations in short-term outcomes among patients with first or recurrent ischemic stroke: Paul Coverdell National Acute Stroke Program, 2016-2020 Open
View article: Obstructive sleep apnea, nocturnal hypoxemia, and retinal microvasculature: The Atherosclerosis Risk in Communities Study
Obstructive sleep apnea, nocturnal hypoxemia, and retinal microvasculature: The Atherosclerosis Risk in Communities Study Open
Study Objectives Retinal microvascular pathology (RMP) and obstructive sleep apnea (OSA) are both cardiovascular disease risk factors. Limited data exists on their interrelationship. We tested the hypotheses that OSA and nocturnal hypoxemi…
View article: FORMING AGING RESEARCH TEAMS THROUGH SPECIAL INTEREST GROUPS: THE GRADUATE STUDENT EXPERIENCE
FORMING AGING RESEARCH TEAMS THROUGH SPECIAL INTEREST GROUPS: THE GRADUATE STUDENT EXPERIENCE Open
The study of aging is inherently interdisciplinary, requiring formation of collaborative research teams that span a variety of fields and disciplinary backgrounds. This team approach is essential for answering complex, multifaceted questio…
View article: Post-Stroke Brain Health Monitoring and Optimization: A Narrative Review
Post-Stroke Brain Health Monitoring and Optimization: A Narrative Review Open
Significant advancements have been made in recent years in the acute treatment and secondary prevention of stroke. However, a large proportion of stroke survivors will go on to have enduring physical, cognitive, and psychological disabilit…
View article: Black business ownership and self-reported stroke risk factors among Black residents
Black business ownership and self-reported stroke risk factors among Black residents Open
CONTEXT: Racial differences in stroke incidence may be explained by area-level racial differences in economic power. OBJECTIVE: To examine the association between Black business ownership and stroke risk factors among Black adults. STUDY D…
View article: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia Open
This study provides Class III evidence that the use of prescribed PPIs for >4.4 years by individuals aged 45 years and older is associated with a higher incidence of newly diagnosed dementia.
View article: Association Between Ischemic Stroke Subtype and Stroke Severity
Association Between Ischemic Stroke Subtype and Stroke Severity Open
Embolic stroke was associated with greater stroke severity at the time of the event and a higher risk of death vs thrombotic stroke, even after careful adjustment for patient-level differences.
View article: P19-051-23 Dietary Carbohydrate Quality Is Associated With Epigenetic Age Acceleration: A Longitudinal Study of the Coronary Artery Risk Development in Young Adults (CARDIA) Cohort
P19-051-23 Dietary Carbohydrate Quality Is Associated With Epigenetic Age Acceleration: A Longitudinal Study of the Coronary Artery Risk Development in Young Adults (CARDIA) Cohort Open
View article: The role of population-level preventive care for brain health in ageing
The role of population-level preventive care for brain health in ageing Open
Over the past several decades, a worldwide demographic transition has led to an increasing number of older adults with chronic neurological conditions. These conditions, which have a profound effect on the cognitive function and physical a…
View article: Procedure-Specific Center Volume and Mortality After Infantile Congenital Heart Surgery
Procedure-Specific Center Volume and Mortality After Infantile Congenital Heart Surgery Open
View article: Trends in intravenous thrombolysis utilization for acute ischemic stroke based on hospital size: Paul Coverdell National Acute Stroke Program, 2010–2019
Trends in intravenous thrombolysis utilization for acute ischemic stroke based on hospital size: Paul Coverdell National Acute Stroke Program, 2010–2019 Open
View article: OSA and Subsequent Risk of Hospitalization With Pneumonia, Respiratory Infection, and Total Infection
OSA and Subsequent Risk of Hospitalization With Pneumonia, Respiratory Infection, and Total Infection Open
View article: High Incidence and Unique Features of Cerebral Venous Sinus Thrombosis in Hospitalized Patients With COVID-19 Infection
High Incidence and Unique Features of Cerebral Venous Sinus Thrombosis in Hospitalized Patients With COVID-19 Infection Open
Background: Cerebral venous sinus thrombosis (CVST) secondary to vaccine-induced thrombotic thrombocytopenia is an extremely rare side effect of adenovirus-based COVID-19 vaccines. CVST incidence associated with COVID-19 itself has not bee…
View article: Correction to: Effects of a robot‐aided somatosensory training on proprioception and motor function in stroke survivors
Correction to: Effects of a robot‐aided somatosensory training on proprioception and motor function in stroke survivors Open
View article: Simulation and Machine Learning Provide New Approaches to Examine Quality of Acute Stroke Management
Simulation and Machine Learning Provide New Approaches to Examine Quality of Acute Stroke Management Open
View article: Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study
Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study Open
We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990–1992) and PET scans (2012–2014…
View article: Mobile health technology for hypertension management with Hmong and Latino adults: mixed-methods community-based participatory research
Mobile health technology for hypertension management with Hmong and Latino adults: mixed-methods community-based participatory research Open
In general, Hmong and Latino adults responded positively to the empowering aspects of the mHealth-based care model, but expressed caution for those who had limited technological knowledge, who did not agree with the medical model and who m…
View article: Changes in physical activity and risk of ischemic stroke: The ARIC study
Changes in physical activity and risk of ischemic stroke: The ARIC study Open
Background: Limited data exist regarding the impact of changes in physical activity (PA) over time on ischemic stroke risk. Exploring this understudied area could help improve stroke prevention strategies and promote PA during the lifespan…
View article: Association of Carotid Intima-Media Thickness with Brain MRI Markers in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
Association of Carotid Intima-Media Thickness with Brain MRI Markers in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) Open
View article: Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study
Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study Open
In this study, risk of dementia significantly increased after ischemic stroke, independent of vascular risk factors. Results suggest a dose-response association of stroke severity and recurrence with risk of dementia.
View article: Association of Ischemic Stroke Incidence, Severity, and Recurrence with Dementia in the Atherosclerosis Risk in Communities Cohort Study
Association of Ischemic Stroke Incidence, Severity, and Recurrence with Dementia in the Atherosclerosis Risk in Communities Cohort Study Open
Importance: Ischemic stroke is associated with increased risk of dementia, but the association of stroke severity and recurrence with risk of impaired cognition is not well known. Objective: To examine the risk of dementia after incident i…
View article: The prospective association between periodontal disease and brain imaging outcomes: The Atherosclerosis Risk in Communities study
The prospective association between periodontal disease and brain imaging outcomes: The Atherosclerosis Risk in Communities study Open
Aim We investigate if periodontal disease is prospectively associated with cerebrovascular and neurodegenerative markers of dementia and Alzheimer's pathology. Materials and Methods N = 1306 participants (Visit 5 mean age = 76.5 [standard …
View article: Body mass index prediction rule for mid-upper arm circumference: the atherosclerosis risk in communities study
Body mass index prediction rule for mid-upper arm circumference: the atherosclerosis risk in communities study Open
Objectives Electronic health records (EHR) are a convenient data source for clinical trial recruitment and allow for inexpensive participant screening. However, EHR may lack pertinent screening variables. One strategy is to identify surrog…