Krishan Gupta
YOU?
Author Swipe
View article: Network based simultaneous embedding of cells and marker genes from scRNA-seq studies
Network based simultaneous embedding of cells and marker genes from scRNA-seq studies Open
The complexity of scRNA-sequencing datasets highlights the urgent need for enhanced clustering and visualization methods. Here, we propose Stardust, an iterative, force-directed graph layout algorithm that enables the simultaneous embeddin…
View article: Clinical and Laboratory Parameters Predicting Frailty in End-Stage Kidney Disease Patients on Maintenance Dialysis
Clinical and Laboratory Parameters Predicting Frailty in End-Stage Kidney Disease Patients on Maintenance Dialysis Open
Background In the context of ESKD patients undergoing maintenance hemodialysis, frailty has emerged as a significant concern, with high prevalence ranging from 30% to >70%. In India, where the burden of CKD is increasing, understanding the…
View article: Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis through Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9-Mediated Low-density Lipoprotein Receptor Degradation
Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis through Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9-Mediated Low-density Lipoprotein Receptor Degradation Open
Background The low-density lipoprotein receptor (LDLR) in the liver plays a crucial role in clearing low-density lipoprotein cholesterol (LDL-C) from the bloodstream. This process takes place mainly in the liver. Under atherogenic conditio…
View article: Simultaneous visualization of cells and marker genes from scRNA-seq studies
Simultaneous visualization of cells and marker genes from scRNA-seq studies Open
The complexity of scRNA-sequencing datasets highlights the urgent need for enhanced clustering and visualization methods. Here, we propose Stardust, an iterative, force-directed graph layouting algorithm that enables simultaneous embedding…
View article: StripeDiff: Model-based algorithm for differential analysis of chromatin stripe
StripeDiff: Model-based algorithm for differential analysis of chromatin stripe Open
Multiple recent studies revealed stripes as an architectural feature of three-dimensional chromatin and found stripes connected to epigenetic regulation of transcription. Whereas a couple of tools are available to define stripes in a singl…
View article: Modeling expression ranks for noise-tolerant differential expression analysis of scRNA-seq data
Modeling expression ranks for noise-tolerant differential expression analysis of scRNA-seq data Open
Systematic delineation of complex biological systems is an ever-challenging and resource-intensive process. Single-cell transcriptomics allows us to study cell-to-cell variability in complex tissues at an unprecedented resolution. Accurate…
View article: Erratum: Iyer, A., et al. Integrative Analysis and Machine Learning Based Characterization of Single Circulating Tumor Cells. J. Clin. Med. 2020, 9, 1206
Erratum: Iyer, A., et al. Integrative Analysis and Machine Learning Based Characterization of Single Circulating Tumor Cells. J. Clin. Med. 2020, 9, 1206 Open
In the published manuscript [...]
View article: Evaluation of Serum Cystatin C as an Early Biomarker of Acute Kidney Injury in Patients with Acute Pancreatitis
Evaluation of Serum Cystatin C as an Early Biomarker of Acute Kidney Injury in Patients with Acute Pancreatitis Open
Patel ML, Shyam R, Bharti H, Sachan R, Gupta KK, Parihar A. Evaluation of Serum Cystatin C as an Early Biomarker of Acute Kidney Injury in Patients with Acute Pancreatitis. Indian J Crit Care Med 2020;24(9):777-782.
View article: Analysis of single-cell transcriptomes links enrichment of olfactory receptors with cancer cell differentiation status and prognosis
Analysis of single-cell transcriptomes links enrichment of olfactory receptors with cancer cell differentiation status and prognosis Open
Ectopically expressed olfactory receptors (ORs) have been linked with multiple clinically-relevant physiological processes. Previously used tissue-level expression estimation largely shadowed the potential role of ORs due to their overall …
View article: The Cellular basis of loss of smell in 2019-nCoV-infected individuals
The Cellular basis of loss of smell in 2019-nCoV-infected individuals Open
A prominent clinical symptom of 2019-novel coronavirus (nCoV) infection is hyposmia/anosmia (decrease or loss of sense of smell), along with general symptoms such as fatigue, shortness of breath, fever and cough. The identity of the cell l…
View article: AI-based multi-modal integration (ScanCov scores) of clinical characteristics, lab tests and chest CTs improves COVID-19 outcome prediction of hospitalized patients
AI-based multi-modal integration (ScanCov scores) of clinical characteristics, lab tests and chest CTs improves COVID-19 outcome prediction of hospitalized patients Open
The SARS-COV-2 pandemic has put pressure on Intensive Care Units, and made theidentification of early predictors of disease severity a priority. We collected clinical,biological, chest CT scan data, and radiology reports from 1,003 coronav…
View article: Integrative Analysis and Machine Learning Based Characterization of Single Circulating Tumor Cells
Integrative Analysis and Machine Learning Based Characterization of Single Circulating Tumor Cells Open
We collated publicly available single-cell expression profiles of circulating tumor cells (CTCs) and showed that CTCs across cancers lie on a near-perfect continuum of epithelial to mesenchymal (EMT) transition. Integrative analysis of CTC…
View article: The molecular basis of loss of smell in 2019-nCoV infected individuals
The molecular basis of loss of smell in 2019-nCoV infected individuals Open
Among the prominent clinical symptoms such as fatigue, shortness of breath, fever, and cough, 2019-nCoV infected individuals often experience hyposmia/anosmia (decrease or loss of sense of smell). Angiotensin I Converting Enzyme 2 (ACE2), …
View article: Integrative analysis and machine learning based characterization of single circulating tumor cells
Integrative analysis and machine learning based characterization of single circulating tumor cells Open
We collated publicly available single-cell expression profiles of circulating tumor cells (CTCs) and showed that CTCs across cancers lie on a near-perfect continuum of epithelial to mesenchymal (EMT) transition. Integrative analysis of CTC…
View article: Assessment of subclinical atherosclerosis and endothelial dysfunction in chronic kidney disease by measurement of carotid intima media thickness and flow-mediated vasodilatation in North Indian population
Assessment of subclinical atherosclerosis and endothelial dysfunction in chronic kidney disease by measurement of carotid intima media thickness and flow-mediated vasodilatation in North Indian population Open
CKD confers a higher inflammatory status when compared with apparently healthy general population. Abnormal FMD responses and CIMT values are more commonly found in dialysis patients. Our findings suggest that CIMT and FMD can be used as n…
View article: Biological approach in repair of partially inflamed dental pulp using second-generation platelet-rich fibrin and mineral trioxide aggregate as a pulp medicament in primary molars
Biological approach in repair of partially inflamed dental pulp using second-generation platelet-rich fibrin and mineral trioxide aggregate as a pulp medicament in primary molars Open
All materials used in the present study were equally effective as the success rates are statistically insignificant.
View article: ROSeq: Modeling expression ranks for noise-tolerant differential expression analysis of scRNA-Seq data
ROSeq: Modeling expression ranks for noise-tolerant differential expression analysis of scRNA-Seq data Open
1 Abstract Systematic delineation of complex biological systems is an ever-challenging and resource-intensive process. Single cell transcriptomics allows us to study cell-to-cell variability in complex tissues at an unprecedented resolutio…
View article: First and Second Metatarsophalangeal Joint Open Dislocations: A Case Report
First and Second Metatarsophalangeal Joint Open Dislocations: A Case Report Open
Dislocation of multiple metatarsophalangeal joint is an uncommon injury. The mechanism of injury is a high energy force distal to proximal with foot in hyperextension at the metatarsophalangeal (MTP) joint. The acute hyperextension of the …
View article: Reduction of microalbuminuria in type-2 diabetes mellitus with angiotensin-converting enzyme inhibitor alone and with cilnidipine
Reduction of microalbuminuria in type-2 diabetes mellitus with angiotensin-converting enzyme inhibitor alone and with cilnidipine Open
The aim of our study was to find out the antiproteinuric effect of enalapril angiotensin-converting enzyme (ACE inhibitor) alone or in combination with cilnidipine in patients with type-2 diabetes mellitus. The study was conducted on 71 pa…
View article: Performance of geosynthetic reinforcement on the ballasted railway track
Performance of geosynthetic reinforcement on the ballasted railway track Open
Geosynthetics provide an important option to improve track support stabilization and thereby reduce the track maintenance costs and operation costs due to train delays. In railroad construction, geosynthetics may be installed within or ben…