Kamalini G. Ranasinghe
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View article: Distinct manifestations of excitatory-inhibitory imbalance associated with amyloid-β and tau in patients with Alzheimer’s disease
Distinct manifestations of excitatory-inhibitory imbalance associated with amyloid-β and tau in patients with Alzheimer’s disease Open
A growing body of evidence shows that epileptic activity is frequently observed in patients with Alzheimer’s disease (AD), implicating underlying excitatory-inhibitory imbalance. The distinction of whether the AD-epileptic phenotype repres…
View article: Back to the Future: Predicting Individual Tau Progression in Alzheimer’s Disease
Back to the Future: Predicting Individual Tau Progression in Alzheimer’s Disease Open
Alzheimer's Disease (AD) is characterized by the spread of tau neurofibrillary tangles along the brain's structural network. The marked variability in pathology spread patterns across individuals necessitates a precision medicine approach.…
View article: 0042 Rest-activity-patterns and Daytime Napping Differ Across Alzheimer’s Disease Phenotypes
0042 Rest-activity-patterns and Daytime Napping Differ Across Alzheimer’s Disease Phenotypes Open
Introduction Sleep disruption in Alzheimer’s disease (AD) is common, linked to cognitive decline, and a major cause of institutionalization. While AD is associated with increased daytime napping, nocturnal wakefulness, and disrupted rest-a…
View article: Integrating Event-Based and Biophysical Models to Predict Individual Tau Progression in Alzheimer's Disease
Integrating Event-Based and Biophysical Models to Predict Individual Tau Progression in Alzheimer's Disease Open
Alzheimer's Disease (AD) is characterized by the accumulation of tau neurofibrillary tangles, which spread along the brain's white matter tracts and correlate with cognitive de-cline. Modeling and predicting tau progression is crucial for …
View article: Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer’s disease
Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer’s disease Open
This mathematical exposition of the "pas de deux" of co-evolving proteins provides quantitative, whole-brain support to the concept of amyloid-facilitated-tauopathy rather than the classic amyloid-cascade or pure-tau hypotheses, and helps …
View article: High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations
High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations Open
Alzheimer's disease increases the risk of developing epilepsy together with cognitive decline. Early diagnosis or prediction of parameters associated with epileptic activity can greatly help in managing disease outcomes. Network hyperexcit…
View article: Neurophysiological signatures of ageing: compensatory and compromised neural mechanisms
Neurophysiological signatures of ageing: compensatory and compromised neural mechanisms Open
Spatiotemporal patterns of neural oscillations change with ageing, even in the cognitively unimpaired individual. Whether these neurophysiological changes represent ageing-related vulnerabilities or mechanisms that support cognitive resili…
View article: To be or not to be! – A case of an aging transvestite presenting with gender dysphoria
To be or not to be! – A case of an aging transvestite presenting with gender dysphoria Open
Gender dysphoria is defined as the incongruence between one's expressed gender and assigned sex at birth. We present a case of an elderly male with a history of transvestism and autogynephilia, seeking transition to female gender in the ba…
View article: High Frequency Oscillations in Epileptic and Non‐Epileptic Alzheimer’s Disease Patients and the Effect of Levetiracetam on the Oscillations
High Frequency Oscillations in Epileptic and Non‐Epileptic Alzheimer’s Disease Patients and the Effect of Levetiracetam on the Oscillations Open
Background Altered network synchronization and rhythmic neural activity is observed in Alzheimer’s disease (AD). Spontaneous epileptiform activity and/or seizures occur in an estimated 60% of AD cases, and having AD increases the likelihoo…
View article: Distinct associations of excitatory‐inhibitory (E/I) imbalance in aging and in Alzheimer’s disease
Distinct associations of excitatory‐inhibitory (E/I) imbalance in aging and in Alzheimer’s disease Open
Background Neural circuit hyperexcitability and impaired excitation‐to‐inhibition (E/I) activity is believed to be a key contributor to synaptic and network degeneration in Alzheimer’s disease (AD). Extensive preclinical research on transg…
View article: Concordance between amyloid-PET quantification and real-world visual reads: results from IDEAS
Concordance between amyloid-PET quantification and real-world visual reads: results from IDEAS Open
Amyloid-PET detects fibrillar β-amyloid deposits, a defining feature of Alzheimer’s disease. This technology has been used in research for over 20 years, and is now used in clinical practice to guide patient diagnosis and management. Howev…
View article: Pitch corrections occur in natural speech and are abnormal in patients with Alzheimer's disease
Pitch corrections occur in natural speech and are abnormal in patients with Alzheimer's disease Open
Past studies have explored formant centering, a corrective behavior of convergence over the duration of an utterance toward the formants of a putative target vowel. In this study, we establish the existence of a similar centering phenomeno…
View article: Author Response: Neurophysiological trajectories in Alzheimer’s disease progression
Author Response: Neurophysiological trajectories in Alzheimer’s disease progression Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Materials and methods Results Discussion Data availability References Article and author information Metrics Abstract Alzheimer's disease (AD) is ch…
View article: Neurophysiological trajectories in Alzheimer’s disease progression
Neurophysiological trajectories in Alzheimer’s disease progression Open
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction, and progressive neurodegeneration and cognitive decline. Altered neural oscillations have been consistently…
View article: Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling Open
INTRODUCTION Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost‐e…
View article: Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer’s disease
Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the most common form of dementia, progressively impairing cognitive abilities. While neuroimaging studies have revealed functional abnormalities in AD, how these relate to aberrant neuronal circuit me…
View article: Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer’s Disease
Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer’s Disease Open
INTRODUCTION The interaction of amyloid and tau in neurodegenerative diseases is a central feature of AD pathophysiology. While experimental studies point to various interaction mechanisms, their causal direction and mode (local, remote or…
View article: Global MEG Resting State Functional Connectivity in Children with Autism and Sensory Processing Dysfunction
Global MEG Resting State Functional Connectivity in Children with Autism and Sensory Processing Dysfunction Open
Sensory processing dysfunction not only affects most individuals with autism spectrum disorder (ASD), but at least 5% of children without ASD also experience dysfunctional sensory processing. Our understanding of the relationship between s…
View article: Spatiotemporal characteristics of neurophysiological changes in patients with four‐repeat tauopathies
Spatiotemporal characteristics of neurophysiological changes in patients with four‐repeat tauopathies Open
Introduction Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), are the most common four‐repeat tauopathies (4RT), and both frequently occur with varying degree of Alzheimer's disease (AD) copathology. Intriguingly, …
View article: Neurophysiological trajectories in Alzheimer’s disease progression
Neurophysiological trajectories in Alzheimer’s disease progression Open
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction and progressive neurodegeneration and cognitive decline. Altered neural oscillations have been consistently …
View article: Author Response: Neurophysiological trajectories in Alzheimer’s disease progression
Author Response: Neurophysiological trajectories in Alzheimer’s disease progression Open
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction and progressive neurodegeneration and cognitive decline. Altered neural oscillations have been consistently …
View article: Author Response: Neurophysiological trajectories in Alzheimer’s disease progression
Author Response: Neurophysiological trajectories in Alzheimer’s disease progression Open
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction and progressive neurodegeneration and cognitive decline. Altered neural oscillations have been consistently …
View article: Abnormal gamma phase-amplitude coupling in the parahippocampal cortex is associated with network hyperexcitability in Alzheimer’s disease
Abnormal gamma phase-amplitude coupling in the parahippocampal cortex is associated with network hyperexcitability in Alzheimer’s disease Open
While animal models of Alzheimer’s disease (AD) have shown altered gamma oscillations (∼40 Hz) in local neural circuits, the low signal-to-noise ratio of gamma in the resting human brain precludes its quantification via conventional spectr…
View article: Neurophysiological Signatures of Aging: Compensatory and Compromised Neural Mechanisms
Neurophysiological Signatures of Aging: Compensatory and Compromised Neural Mechanisms Open
View article: Quantitative Amyloid‐PET in Real‐World Practice: Lessons from the Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) study
Quantitative Amyloid‐PET in Real‐World Practice: Lessons from the Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) study Open
Background Amyloid‐PET quantification was developed in research settings using highly selected samples, harmonized acquisition protocols, and MRI‐based preprocessing. We aimed to analyze scans from IDEAS, a large‐scale, real‐world study of…
View article: Neurophysiological changes associated with plasma p‐tau represent functional effects of amyloid accumulation and are modulated by APOE.
Neurophysiological changes associated with plasma p‐tau represent functional effects of amyloid accumulation and are modulated by APOE. Open
Background Alzheimer disease (AD) is defined by the presence of cerebral amyloid‐β plaques and tau neurofibrillary tangles (NFT). Neurophysiological manifestations which depict the functional changes of neurons and circuits, demonstrate th…
View article: Neuronal hyperexcitability in AD
Neuronal hyperexcitability in AD Open
Background Because neuronal and network deficits are the imperative immediate consequences of pathological changes of disease mechanisms, neurophysiological manifestations associated with Aβ and tau are uniquely positioned to demonstrate t…
View article: Spectral graph modeling reveals global slowing of neurophysiological network transmission in Alzheimer’s disease
Spectral graph modeling reveals global slowing of neurophysiological network transmission in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the most common form of dementia, progressively impairing memory and cognition. While various neuroimaging studies have revealed functional network abnormalities in patients with AD, how these relate …
View article: Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer’s disease
Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer’s disease Open
Alzheimer’s disease (AD) is the most common form of dementia, progressively impairing memory and cognition. While neuroimaging studies have revealed functional abnormalities in AD, how these relate to aberrant neuronal circuit mechanisms r…
View article: Reviewer #2 (Public Review): Neurophysiological trajectories in Alzheimer’s disease progression
Reviewer #2 (Public Review): Neurophysiological trajectories in Alzheimer’s disease progression Open
Alzheimer's disease (AD) is characterized by accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction and progressive neurodegeneration and cognitive decline. Altered neural oscillations have been consistently demo…