Kamatham Pushpa Tryphena
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View article: Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the NRF2/BNIP3/PINK1 Axis in the MPP<sup>+</sup> Iodide-Induced Parkinson’s Disease Mice Model
Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the NRF2/BNIP3/PINK1 Axis in the MPP<sup>+</sup> Iodide-Induced Parkinson’s Disease Mice Model Open
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder linked to the loss of dopaminergic neurons in the substantia nigra. Mitophagy, mitochondrial selective autophagy, is critical in maintaining mitochondrial and…
View article: CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective
CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective Open
Adv. Sci. 2023, 10, 2207512 DOI: 10.1002/advs.202207512 In the original published article, Satoru Kawakita and Shahid Khan affiliations are swapped. Please find below the correct affiliations. D. K. Sahel Department of Pharmacy Birla Insti…
View article: CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective
CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective Open
Clustered randomly interspaced short palindromic repeats (CRISPRs) and its associated endonuclease protein, i.e., Cas9, have been discovered as an immune system in bacteria and archaea; nevertheless, they are now being adopted as mainstrea…
View article: Microtubule acetylation dyshomeostasis in Parkinson’s disease
Microtubule acetylation dyshomeostasis in Parkinson’s disease Open
The inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated axonal transport system. This mechanistically regulated system delivers cargos (proteins, mRNAs a…
View article: CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease
CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease Open
Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to correct the causative gene mutation and establish animal models in neurodegenerative disorders. Since no strategy developed until now could completel…
View article: Inter and intracellular mitochondrial transfer: Future of mitochondrial transplant therapy in Parkinson’s disease
Inter and intracellular mitochondrial transfer: Future of mitochondrial transplant therapy in Parkinson’s disease Open
Parkinson's disease (PD) is marked by the gradual degeneration of dopaminergic neurons and the intracellular build-up of Lewy bodies rich in α-synuclein protein. This impairs various aspects of the mitochondria including the generation of …
View article: Epigenetics in depression and gut-brain axis: A molecular crosstalk
Epigenetics in depression and gut-brain axis: A molecular crosstalk Open
Gut-brain axis is a dynamic, complex, and bidirectional communication network between the gut and brain. Changes in the microbiota-gut-brain axis are responsible for developing various metabolic, neurodegenerative, and neuropsychiatric dis…
View article: Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s Disease
Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s Disease Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease, affecting the elderly worldwide and causing significant movement impairments. The goal of PD treatment is to restore dopamine levels in the striatum and regulate…