Kambiz N. Alavian
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View article: Implementing an integrated epistemic framework: a multimodal active learning approach in translational neuroscience
Implementing an integrated epistemic framework: a multimodal active learning approach in translational neuroscience Open
Grounded in Popper’s hypothetico-deductive logic, Kuhn’s focus on anomalies, threshold concepts, and transformative learning, the Virtual Research Project (VRP) turns the scientific method into pedagogy.
View article: Reduced DJ-1-F1Fo ATP synthase association correlates with midbrain dopaminergic neuron vulnerability in idiopathic Parkinson’s disease
Reduced DJ-1-F1Fo ATP synthase association correlates with midbrain dopaminergic neuron vulnerability in idiopathic Parkinson’s disease Open
Disruption in neuronal and synaptic metabolic homeostasis is a key driver of neurodegeneration in Parkinson’s disease (PD). Mitochondrial activity, biomass, and efficiency are critical to this balance. While activity and biomass are well c…
View article: Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement
Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement Open
Background Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased healthspan. With advancing age, the increased prevalence of ageing-related diseases can have a significant…
View article: Threshold Concepts in Neuroscience: Identification Challenges, Educational Opportunities and Recommendations for Practice
Threshold Concepts in Neuroscience: Identification Challenges, Educational Opportunities and Recommendations for Practice Open
Threshold concepts are recent, yet already established, aspects of medical education. However, they represent a new area in neuroscience education, especially given the recency of neuroscience as a field of research in its own right when c…
View article: The factors for the early and late development of midbrain dopaminergic neurons segregate into two distinct evolutionary clusters
The factors for the early and late development of midbrain dopaminergic neurons segregate into two distinct evolutionary clusters Open
Midbrain dopaminergic neurons are responsible for several functions in the reward system, control of emotion, motivation, cognition, and motor behavior. A set of well-characterized transcription factors involved in specification, neurogene…
View article: Issue Information
Issue Information Open
Frank Krause (FASeB, non-voting) thoru Pederson (FASeB, non-voting
View article: The mitochondrial metabolic function of <i>DJ‐1</i> is modulated by <i>14‐3‐3β</i>
The mitochondrial metabolic function of <i>DJ‐1</i> is modulated by <i>14‐3‐3β</i> Open
Mitochondrial metabolic plasticity is a key adaptive mechanism in response to changes in cellular metabolic demand. Changes in mitochondrial metabolic efficiency have been linked to pathophysiological conditions, including cancer, neurodeg…
View article: MOESM4 of PhySpeTree: an automated pipeline for reconstructing phylogenetic species trees
MOESM4 of PhySpeTree: an automated pipeline for reconstructing phylogenetic species trees Open
Additional file 4. Data used to extend tree-of-life with Lokiarchaeum sp. GC14_75. “FastTree.tree” is the output tree file. “tree_of_life_species_names_abb.txt” contains the species abbreviated names to use reconstruct tree-of-life. “highl…
View article: MOESM1 of PhySpeTree: an automated pipeline for reconstructing phylogenetic species trees
MOESM1 of PhySpeTree: an automated pipeline for reconstructing phylogenetic species trees Open
Additional file 1: Figure S1. The taxonomic distribution of species supported by the HCP (A) and SSU rRNA options (B).
View article: PrePhyloPro: phylogenetic profile-based prediction of whole proteome linkages
PrePhyloPro: phylogenetic profile-based prediction of whole proteome linkages Open
Direct and indirect functional links between proteins as well as their interactions as part of larger protein complexes or common signaling pathways may be predicted by analyzing the correlation of their evolutionary patterns. Based on phy…