Explanipedia

Vaccines and the risk of Guillain-Barré syndrome: A French pharmacovigilance analysis Open

Marie Gligorov, Bénédicte Lebrun-Vignes, Kamel Masmoudi, Thierry Vial, Helga Junot , et al. · 2025

This study suggests that Guillain-Barré syndrome may be a rare but potentially severe adverse event that can occur in the first few weeks after vaccination whatever its nature. Even if a vaccine was injected in the weeks preceding the firs…

Clinical and electroencephalographic particularities of children and adolescents with behavioral disorders Open

R. Bouchech, A. Fki, Inès Kammoun, Kamel Masmoudi · 2024

Introduction Behavioral disorders are a frequent reason for consultation in child psychiatry. Children and adolescents with epilepsy are at risk of behavioral disorders that can affect their quality of life. Objectives The aim of this stud…

#5647 EFFECT OF STATINS ON THE INCIDENCE OF CARDIOVASCULAR EVENTS AFTER KIDNEY TRANSPLANTATION Open

Benjamin Batteux, Charifa Nazoiri, François Brazier, Alban Nowak, Youssef Benis , et al. · 2023

Background and Aims Based on intervention thresholds [1], statins are recommended in kidney transplant recipients (KTRs) who are at high risk for major cardiovascular (CV) events. However, in this population, evidence of statin effectivene…

COVID-19 et vaccins à adénovirus : expérience française de suivi renforcé de pharmacovigilance Open

Nathalie Massy, Marina Atzenhoffer, Charlène Boulay, Pauline-Eva Pecquet, Fanny Ledys , et al. · 2023

Drugs associated with incident fragility fractures in kidney transplant recipients Open

Benjamin Batteux, Alban Nowak, Alice Séjourné, Clémence Penet, Kamel Masmoudi , et al. · 2022

Background The risk of fragility fractures is high in kidney transplant recipients, and steroids are reportedly a major cause. Other drugs known to induce fragility fractures have been studied in the general population but not in kidney tr…

Fetal and Neonatal Adverse Drug Reactions Associated with Biologics Taken During Pregnancy by Women with Autoimmune Diseases: Insights from an Analysis of the World Health Organization Pharmacovigilance Database (VigiBase®) Open

A. Dernoncourt, Sophie Liabeuf, Youssef Bennis, Kamel Masmoudi, Sandra Bodeau , et al. · 2022

We identified possible associations with some adverse fetal and neonatal outcomes, suggesting that vigilance is required when prescribing certain biologics during pregnancy.

Use of the Capture-Recapture Method to Estimate the Frequency of Community- and Hospital-Acquired Drug-Induced Acute Kidney Injuries in French Databases Open

Amayelle Rey, Valérie Gras, Julien Moragny, Gabriel Choukroun, Kamel Masmoudi , et al. · 2022

Drug-induced acute kidney injury (AKI) can occur both in primary care (i.e., community-acquired AKI (CA-AKI)) and in hospital settings (i.e., hospital-acquired AKI (HA-AKI)). The reported prevalence of these events varies markedly from one…

Guillain–Barré Syndrome Associated with COVID-19 Vaccines: A Perspective From Spontaneous Report Data Open

Marina Atzenhoffer, Marine Auffret, Antoine Pégat, Kamel Masmoudi, Charles Khouri , et al. · 2022

Risk factors for and characteristics of community‐ and hospital‐acquired drug‐induced acute kidney injuries Open

Amayelle Rey, Valérie Gras‐Champel, Gabriel Choukroun, Kamel Masmoudi, Sophie Liabeuf · 2022

Drugs constitute one of the leading causes of acute kidney injuries (AKIs) and can appear in community (CA‐AKI) or hospital (HA‐AKI) population. The objectives of the present study of a cohort of hospitalized patients with AKI were to desc…

Adaptation du kit de dépistage urinaire des benzodiazépines Atellica™ Siemens™ à la matrice sérique Open

Touria Mernissi, Camille André, Anaïs Périn, Chloé Thézée, Claudie Talandier , et al. · 2022

Adenovirus <span>COVID‐19</span> Vaccines and Guillain–Barré Syndrome with Facial Paralysis Open

Antoine Pégat, Alberto Vogrig, Charles Khouri, Kamel Masmoudi, Thierry Vial , et al. · 2021

International audience

Atypical thrombosis associated with VaxZevria® (AstraZeneca) vaccine: Data from the French Network of Regional Pharmacovigilance Centres Open

Valérie Gras-Champel, Sophie Liabeuf, M. Baud, Jean‐François Albucher, M. Benkebil , et al. · 2021

COVID‐19 in DMARD‐treated patients with inflammatory rheumatic diseases: Insights from an analysis of the World Health Organization pharmacovigilance database Open

A. Dernoncourt, J. Schmidt, P. Duhaut, Sophie Liabeuf, Valérie Gras‐Champel , et al. · 2021

Background To determine whether the use of disease‐modifying antirheumatic drugs (DMARDs) is linked to the risk of COVID‐19 among patients with inflammatory rheumatic diseases (IRDs). Methods We performed a disproportionality analysis of t…

Potential interactions between uraemic toxins and drugs: an application in kidney transplant recipients treated with calcineurin inhibitors Open

Camille André, Gabriel Choukroun, Youssef Bennis, Saı̈d Kamel, Anne Sophie Lemaire-Hurtel , et al. · 2021

Background The uraemic toxins that accumulate as renal function deteriorates can potentially affect drug pharmacokinetics. This study’s objective was to determine whether plasma concentrations of certain uraemic toxins are correlated with …

Impact of the COVID-19 outbreak on the reporting of adverse drug reactions associated with self-medication Open

Maria Gras, V. Gras-Champel, Julien Moragny, Pascal Delaunay, Delphine Laugier , et al. · 2021

Impact of the corticosteroid indication and administration route on overall survival and the tumor response after immune checkpoint inhibitor initiation Open

L Gaucher, Leslie Adda, Alice Séjourné, Camille Joachim, G. Chaby , et al. · 2021

Background: Based on their indications, systemic corticosteroids appear to negatively affect clinical outcomes in immune checkpoint inhibitor (ICI)-treated patients. There are few data on the influence of topical and inhaled corticosteroid…

Associations between dysbiosis-inducing drugs, overall survival and tumor response in patients treated with immune checkpoint inhibitors Open

L Gaucher, Leslie Adda, Alice Séjourné, Camille Joachim, G. Chaby , et al. · 2021

Background: There are conflicting data on the effects of dysbiosis-inducing drugs, and especially antibiotics (ATBs), on clinical outcomes in patients treated with immune checkpoint inhibitors (ICIs). There is a particular lack of data for…

Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation Open

Benjamin Batteux, Sandra Bodeau, Camille André, Anne‐Sophie Hurtel‐Lemaire, Valérie Gras‐Champel , et al. · 2020

Although uremic osteoporosis is a component of mineral and bone disorder in chronic kidney disease, uremic toxin (UT) concentrations in patients with end-stage kidney disease and bone mineral density (BMD) changes after kidney transplantat…

Evaluation of Changes Over Time in the Drug Burden and Medication Regimen Complexity in ESRD Patients Before and After Renal Transplantation Open

Justine Marienne, Solène M. Laville, Pauline Caillard, Benjamin Batteux, Valérie Gras‐Champel , et al. · 2020

In kidney transplant recipients, the drug burden and MRCI were greater at all time points after transplantation than before transplantation. The impact of the drug burden and MRC on medication adherence and clinical outcomes in these patie…

Toxicocinétique de la colchicine au cours d’une intoxication aiguë sévère d’issue favorable Open

Marie-Charlotte Quinton-Bouvier, Nicolas Fabresse, Sandra Bodeau, Pauline Caillard, Julien Maizel , et al. · 2020

P0879EARLY STEROID WITHDRAWAL HAS A POSITIVE EFFECT ON BONE KIDNEY TRANSPLANT RECIPIENTS: A PROPENSITY SCORE STUDY WITH INVERSE PROBABILITY-OF-TREATMENT WEIGHTING Open

Benjamin Batteux, Valérie Gras‐Champel, Mathilde Lando, François Brazier, Isabelle Desailly-Henry , et al. · 2020

Background and Aims Long-term corticosteroid use after kidney transplantation is associated with a decrease in bone mineral density and a high fracture risk. We hypothesized that patients with early steroid withdrawal (ESW) would display a…

Association between renin–angiotensin system inhibitors and COVID-19 complications Open

Sophie Liabeuf, Julien Moragny, Youssef Bennis, Benjamin Batteux, Étienne Brochot , et al. · 2020

Aims To describe the characteristics of patients hospitalized with COVID-19 (including their long-term at-home medication use), and compare them with regard to the course of the disease. To assess the association between renin–angiotensin …

Self-medication practices and their characteristics among French university students Open

Marion Gras, Valérie Champel, Kamel Masmoudi, Sophie Liabeuf · 2020

Early steroid withdrawal has a positive effect on bone in kidney transplant recipients: a propensity score study with inverse probability-of-treatment weighting Open

Benjamin Batteux, Valérie Gras‐Champel, Mathilde Lando, François Brazier, Romuald Mentaverri , et al. · 2020

Background: Long-term corticosteroid use after kidney transplantation is associated with a decrease in bone mineral density (BMD) and a high fracture risk. We hypothesized that patients with early steroid withdrawal (ESW) would display a g…

Acute kidney injury associated with febuxostat and allopurinol: a post-marketing study Open

Amayelle Rey, Benjamin Batteux, Solène M. Laville, Justine Marienne, Kamel Masmoudi , et al. · 2019

Background For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment. Due to the widespread use of the…

Ischaemic colitis associated with intravitreal administration of aflibercept: A first case report Open

Benjamin Batteux, Valérie Gras, Yanis Mahboud, Sophie Liabeuf, Youssef Bennis , et al. · 2019

In patients with age‐related macular degeneration (AMD), the intravitreal injection of antivascular endothelial growth factor (anti‐VEGF) agents reduces disease progression and choroidal neovascularization. We report on a first case of isc…

TNFalpha inhibitors and amyotrophic lateral sclerosis: a risk factor ? Open

Antoine Coquerel, Nadine Petitpain, David Devos, Haleh Bagheri, Fanny Rocher , et al. · 2018

Background

Neurotoxic Concentration of Piperacillin during Continuous Infusion in Critically Ill Patients Open

M.-C. Quinton, Sandra Bodeau, Loay Kontar, Yoann Zerbib, Julien Maizel , et al. · 2017

This retrospective cohort study included 53 patients admitted to the intensive care unit (ICU), with an average age of 69 years, without neurologic disorder before initiation of a continuous piperacillin infusion at the standard dose and w…

The drugs that mostly frequently induce acute kidney injury: a case − noncase study of a pharmacovigilance database Open

Marion Pierson-Marchandise, Valérie Gras, Julien Moragny, Joëlle Micallef, Louise Gaboriau , et al. · 2016

Aims Acute kidney injury (AKI) is associated with a high hospitalization rate, accelerated long‐term decline in kidney function and a high mortality rate. Adverse drug reactions (ADRs) constitute one of the most important modifiable factor…

Adaptation and validation of an adverse drug reaction preventability score for bleeding due to vitamin K antagonists Open

Sophie Liabeuf, Kamel Masmoudi, Lucie‐Marie Scailteux, Julien Moragny, Henri Masson , et al. · 2016

Although drug therapy is inherently associated with the risk of adverse drug reactions (ADRs), some of these events are preventable. The estimated proportion of preventable ADRs varies from one study or clinical context to another. Bleedin…

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