Kamil Wnuk
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View article: Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss in Spike
Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss in Spike Open
To provide a unique global view of the relative potential for evasion of CD8+ and CD4+ T cells by SARS-CoV-2 lineages as they evolve over time, we performed a comprehensive analysis of predicted HLA-I and HLA-II binding peptides in Spike (…
View article: Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss In Spike
Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss In Spike Open
To provide a unique global view of the relative potential for evasion of CD8+ and CD4+ T cells by SARS-CoV-2 lineages as they evolve over time, we performed a comprehensive analysis of predicted HLA-I and HLA-II binding peptides in spike (…
View article: Prime hAd5 Spike + Nucleocapsid Vaccination Induces Ten-Fold Increases in Mean T-Cell Responses in Phase 1 Subjects that are Sustained Against Spike Variants
Prime hAd5 Spike + Nucleocapsid Vaccination Induces Ten-Fold Increases in Mean T-Cell Responses in Phase 1 Subjects that are Sustained Against Spike Variants Open
In response to the need for a safe, efficacious vaccine that elicits vigorous T cell as well as humoral protection against SARS-CoV-2 infection, we have developed a dual-antigen COVID-19 vaccine comprising both the viral spike (S) protein …
View article: Sztuka, postsztuka, autosztuka i ...
Sztuka, postsztuka, autosztuka i ... Open
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View article: Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity
Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity Open
DNA accessibility is a key dynamic feature of chromatin regulation that can potentiate transcriptional events and tumor progression. To gain insight into chromatin state across existing tumor data, we improved neural network models for pre…
View article: Deep Learning with Implicit Handling of Tissue-Specific Phenomena Predicts Tumor DNA Accessibility and Immune Activity
Deep Learning with Implicit Handling of Tissue-Specific Phenomena Predicts Tumor DNA Accessibility and Immune Activity Open
View article: Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples
Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples Open
View article: Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples
Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples Open
Immune heterogeneity within the tumor microenvironment undoubtedly adds several layers of complexity to our understanding of drug sensitivity and patient prognosis across various cancer types. Within the tumor microenvironment, immunogenic…
View article: Deep learning with implicit handling of tissue-specific phenomena predicts tumor DNA accessibility and immune activity
Deep learning with implicit handling of tissue-specific phenomena predicts tumor DNA accessibility and immune activity Open
DNA accessibility is a key dynamic feature of chromatin regulation that can potentiate transcriptional events and tumor progression. Recently, neural networks have begun to make it possible to explore the impact of mutations on DNA accessi…