Kamil Zalewski
YOU?
Author Swipe
View article: Circulating MicroRNAs in Patients with Vulvar Squamous Cell Carcinoma and Its Precursors
Circulating MicroRNAs in Patients with Vulvar Squamous Cell Carcinoma and Its Precursors Open
Objectives: Vulvar squamous cell carcinoma (VSCC) is a rare gynecologic malignancy, with most cases arising from differentiated vulvar intraepithelial neoplasia (dVIN). Approximately one-third of VSCC cases originate from high-grade squamo…
View article: Circulating MicroRNAs in Patients with Vulvar Squamous Cell Carcinoma and its Precursors
Circulating MicroRNAs in Patients with Vulvar Squamous Cell Carcinoma and its Precursors Open
Background/Objectives Vulvar squamous cell carcinoma (VSCC) is a rare gynecologic malignancy, with most cases arising from differentiated vulvar intraepithelial neoplasia (dVIN). Approximately one-third of VSCC cases originate from high-gr…
View article: Gender-related differences in career development among gynecologic oncology surgeons in Europe. European Network of Young Gynecologic Oncologists’ Survey based data
Gender-related differences in career development among gynecologic oncology surgeons in Europe. European Network of Young Gynecologic Oncologists’ Survey based data Open
Introduction Gender-related differences in career development are well known issues in various professions. An international survey on gender-related differences was performed among young gynecologic oncology surgeons in Europe to identify…
View article: 293 Quality of training in cervical cancer surgery: a survey from the European network of young gynaecologic oncologists (ENYGO)
293 Quality of training in cervical cancer surgery: a survey from the European network of young gynaecologic oncologists (ENYGO) Open
Introduction/Background* European Society of Gynaecological Oncology (ESGO) and partners are committed to improving the quality of training for gynecological oncology fellows. The aim of this survey was to take a real-life picture of the t…
View article: 984 Impact of SARS-CoV-2 on training and mental wellbeing of surgical gynaecological oncology trainees
984 Impact of SARS-CoV-2 on training and mental wellbeing of surgical gynaecological oncology trainees Open
Introduction/Background* The SARS-CoV-2 global-pandemic has caused a crisis disrupting health systems worldwide. Whilst efforts are afoot to determine the extent of disruption, impact on gynaecological oncology trainees/training has not be…
View article: 757 European Enhanced Recovery After Surgery (ERAS) gynecological oncology survey: current state of perioperative practice
757 European Enhanced Recovery After Surgery (ERAS) gynecological oncology survey: current state of perioperative practice Open
Introduction/Background* Enhanced Recovery After Surgery (ERAS) reduces complication rates after surgery, decreases length of hospital stay (LOS) and reduces costs. A correct implementation of the ERAS protocol and adherence to all ERAS it…
View article: 114 Lower-limb lymphedema after sentinel lymph node biopsy in cervical cancer patients
114 Lower-limb lymphedema after sentinel lymph node biopsy in cervical cancer patients Open
Introduction/Background* Lower-limb lymphedema (LLL) is a well-recognized adverse outcome of the surgical management of cervical cancer. Recently, sentinel lymph node (SLN) biopsy has emerged as an alternative procedure to systematic pelvi…
View article: Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions
Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions Open
Vulvar squamous cell carcinoma (VSCC) develops from high-grade squamous intraepithelial lesions (HSIL) and differentiated vulvar intraepithelial neoplasia (dVIN). This study aimed to assess the diagnostic value of circulating hsa-miR-431-5…
View article: Lower-Limb Lymphedema after Sentinel Lymph Node Biopsy in Cervical Cancer Patients
Lower-Limb Lymphedema after Sentinel Lymph Node Biopsy in Cervical Cancer Patients Open
Background: To prospectively assess LLL incidence among cervical cancer patients treated by uterine surgery complemented by SLN biopsy, without PLND. Methods: A prospective study in 150 patients with stage IA1–IB2 cervical cancer treated b…
View article: Tracers and corresponding detection devices: technetium colloids, blue dyes & NIR fluorescence
Tracers and corresponding detection devices: technetium colloids, blue dyes & NIR fluorescence Open
Tracers and corresponding detection devices for the mapping of sentinel lymph nodes have been evolving since the first use of lymphangiogram methods in 1977 in penile carcinoma. Nowadays a variety of dyes and radiotracers have been validat…
View article: CXCR4/ACKR3/CXCL12 axis in the lymphatic metastasis of vulvar squamous cell carcinoma
CXCR4/ACKR3/CXCL12 axis in the lymphatic metastasis of vulvar squamous cell carcinoma Open
Aims Vulvar squamous cell carcinoma (VSCC) spreads early and mainly locally via direct expansion into adjacent structures, followed by lymphatic metastasis to the regional lymph nodes (LNs). In the lymphatic metastasis, cancer cells bearin…
View article: Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression Open
Current knowledge on the biology of squamous cell vulvar carcinoma (VSCC) is limited. We aimed to identify protein markers of VSCC tumors that would permit to stratify patients by progression risk. Early-stage tumors from patients who prog…
View article: Perspectives, fears and expectations of patients with gynaecological cancers during the COVID‐19 pandemic: A Pan‐European study of the European Network of Gynaecological Cancer Advocacy Groups (ENGAGe)
Perspectives, fears and expectations of patients with gynaecological cancers during the COVID‐19 pandemic: A Pan‐European study of the European Network of Gynaecological Cancer Advocacy Groups (ENGAGe) Open
Background The impact of the COVID‐19 pandemic on European gynaecological cancer patients under active treatment or follow‐up has not been documented. We sought to capture the patient perceptions of the COVID‐19 implications and the worldw…
View article: Sentinel lymph node mapping and intraoperative assessment in a prospective, international, multicentre, observational trial of patients with cervical cancer: The SENTIX trial
Sentinel lymph node mapping and intraoperative assessment in a prospective, international, multicentre, observational trial of patients with cervical cancer: The SENTIX trial Open
SLN biopsy can achieve high bilateral SLN detection in patients with tumours of 4 cm or smaller. At experienced centres, all SLN were found in the pelvis, and most were located below the iliac vessel bifurcation. SLN frozen section assessm…
View article: Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma
Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma Open
Vulvar squamous cell carcinoma (VSCC) originates from the progression of either a high-grade squamous intraepithelial lesion (HSIL) or differentiated-type vulvar intraepithelial neoplasia (dVIN), often in a background of lichen sclerosus (…
View article: Radical vulvectomy with right gluteal and left medial thigh V-Y advancement flap reconstruction
Radical vulvectomy with right gluteal and left medial thigh V-Y advancement flap reconstruction Open
Vulvar cancer is rare. The vulva constitutes the external female genitalia and it is associated with the perineum with the intersection of urinary, sexual and anal systems. The deep anatomy of the perineum in the urogenital and anogenital …
View article: Radical vulvectomy with right gluteal and left medial thigh V-Y advancement flap reconstruction
Radical vulvectomy with right gluteal and left medial thigh V-Y advancement flap reconstruction Open
Vulvar cancer is rarely seen.Vulva corresponds to the external female genitalia and it is in association with the perineum with the intersection of urinary, sexual and anal systems.The deep anatomy of the perineum in the urogenital and ano…
View article: Inflammation as a Driver of Vulvar Squamous Cell Carcinoma Progression.
Inflammation as a Driver of Vulvar Squamous Cell Carcinoma Progression. Open
Background A knowledge on the biology of squamous cell vulvar carcinoma (VSCC) is limited. We aimed to identify protein markers of VSCC tumors stratifying patients by progression risk. Early stage VSCC tumors from patients who progressed (…
View article: An update of the cervical cancer staging system as of 2019
An update of the cervical cancer staging system as of 2019 Open
Klasyfikacje zaawansowania nowotworów złośliwych są podstawowym narzędziem potrzebnym do prawidłowej kwalifikacji do leczenia onkologicznego, podjęcia właściwej decyzji odnośnie do leczenia uzupełniającego, porównywania wyników leczenia or…
View article: Somatic mutations in BRCA1&2 in 201 unselected ovarian carcinoma samples – single institution study
Somatic mutations in BRCA1&2 in 201 unselected ovarian carcinoma samples – single institution study Open
Ovarian cancer (OC) is the most lethal among gynecologic malignancies worldwide. Unfortunately, in around 70% of cases cancer is diagnosed in late stages (III-IV) which decreases the 5-year survival rate to 25%. The standard of care in ova…
View article: Somatic mutation profiling of vulvar cancer: Exploring therapeutic targets
Somatic mutation profiling of vulvar cancer: Exploring therapeutic targets Open
Detecting pathogenic mutations in 13/50 genes examined at comparable frequencies in hrHPV(+) and hrHPV(-) tumors suggest that genetic mechanisms of the two routes of VSCC pathogenesis may be similar, despite being initiated from different …
View article: PO-512 Protein markers of progression risk in patients with squamous cell vulvar carcinoma
PO-512 Protein markers of progression risk in patients with squamous cell vulvar carcinoma Open
Introduction The application of the concept of tumour-specific markers to assess a possible disease outcome and to choose appropriate treatment options, is still obstructed by the limited knowledge on vulvar carcinoma (VC) biology. We aim…
View article: Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma
Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma Open
The role of circulating microRNAs as a promising tool for diagnosing cancer and monitoring anticancer therapies has been widely studied in the past decades. To date, no suitable reference microRNAs for normalizing quantitative real-time po…