Kamran Ahmed
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View article: Parenchyma-sparing resection for a complex jejunal duplication with a shared mesenteric blood supply: a case report
Parenchyma-sparing resection for a complex jejunal duplication with a shared mesenteric blood supply: a case report Open
Gastrointestinal (GI) duplication cysts present significant diagnostic and surgical challenges, particularly with complex anatomy. We report a 2-year-old male with chronic obstructive symptoms caused by a mixed-type jejunal duplication. Wh…
View article: TIP-24. A first-in-human trial of intrathecal cDC1 therapy for breast cancer leptomeningeal disease induces adaptive immunity with transcriptomic evidence of immune awakening in the CSF
TIP-24. A first-in-human trial of intrathecal cDC1 therapy for breast cancer leptomeningeal disease induces adaptive immunity with transcriptomic evidence of immune awakening in the CSF Open
BACKGROUND Leptomeningeal disease (LMD) is a lethal complication of breast cancer (BC), occurring in ~5% of patients and characterized by poor prognosis. The cerebrospinal fluid (CSF) immune environment in LMD is predominantly innate, lack…
View article: 349 A transcriptomic analysis of a first in human phase I trial of intrathecal dendritic cells in patients with leptomeningeal disease show development of adaptive immune responses
349 A transcriptomic analysis of a first in human phase I trial of intrathecal dendritic cells in patients with leptomeningeal disease show development of adaptive immune responses Open
View article: Diagnostic Discordance in a Compromised Host: Acinetobacter Meningitis with Atypical Cerebrospinal Fluid in Pediatric Sturge-Weber Syndrome
Diagnostic Discordance in a Compromised Host: Acinetobacter Meningitis with Atypical Cerebrospinal Fluid in Pediatric Sturge-Weber Syndrome Open
View article: Use of Human Chorionic Gonadotropin (HCG) or HCG-Combined Treatments in Male Infertility: A Systematic Review
Use of Human Chorionic Gonadotropin (HCG) or HCG-Combined Treatments in Male Infertility: A Systematic Review Open
There exists a lack of consensus on the value of human chorionic gonadotropin (HCG) or HCG-combined therapies for the treatment of male infertility. This article aims to evaluate the efficacy and safety of HCG or HCG-combined interventions…
View article: Phase IB study of Avelumab and whole brain radiotherapy in patients with leptomeningeal disease from solid tumors: Results and molecular analyses
Phase IB study of Avelumab and whole brain radiotherapy in patients with leptomeningeal disease from solid tumors: Results and molecular analyses Open
Background Leptomeningeal disease (LMD) from solid tumors has a dismal prognosis, even following treatment with anti-PD-1 therapy. We performed a phase IB study evaluating the safety of Avelumab with whole brain radiotherapy (WBRT) in LMD …
View article: PREVALENCE OF LEFT VENTRICULAR HYPERTROPHY IN UNDIAGNOSED HYPERTENSIVE ADULTS USING ECG SCREENING A CROSS SECTIONAL STUDY
PREVALENCE OF LEFT VENTRICULAR HYPERTROPHY IN UNDIAGNOSED HYPERTENSIVE ADULTS USING ECG SCREENING A CROSS SECTIONAL STUDY Open
Background: Left ventricular hypertrophy (LVH) is a common but often undetected consequence of sustained hypertension and is associated with increased cardiovascular risk. Undiagnosed hypertension in asymptomatic adults may silently contri…
View article: CTSI-01 FINAL RESULTS AND MOLECULAR ANALYSES OF THE PHASE IB CLINICAL TRIAL OF AVELUMAB AND WHOLE BRAIN RADIOTHERAPY (WBRT) IN PATIENTS WITH LEPTOMENINGEAL DISEASE (LMD) FROM SOLID MALIGNANCIES.
CTSI-01 FINAL RESULTS AND MOLECULAR ANALYSES OF THE PHASE IB CLINICAL TRIAL OF AVELUMAB AND WHOLE BRAIN RADIOTHERAPY (WBRT) IN PATIENTS WITH LEPTOMENINGEAL DISEASE (LMD) FROM SOLID MALIGNANCIES. Open
BACKGROUND Leptomeningeal disease (LMD) from solid tumors has a dismal prognosis, even following treatment with anti-PD-1 therapy. We performed a phase IB study evaluating the safety of Avelumab with whole brain radiotherapy (WBRT) in LMD …
View article: BSLD-02 A FIRST IN HUMAN PHASE I TRIAL OF INTRATHECAL DENDRITIC CELLS PRIMED AGAINST HER2/HER3 IN PATIENTS WITH LEPTOMENINGEAL DISEASE FROM TRIPLE-NEGATIVE OR HER2+ BREAST CANCER SHOW DEVELOPMENT OF ADAPTIVE IMMUNE RESPONSES
BSLD-02 A FIRST IN HUMAN PHASE I TRIAL OF INTRATHECAL DENDRITIC CELLS PRIMED AGAINST HER2/HER3 IN PATIENTS WITH LEPTOMENINGEAL DISEASE FROM TRIPLE-NEGATIVE OR HER2+ BREAST CANCER SHOW DEVELOPMENT OF ADAPTIVE IMMUNE RESPONSES Open
BACKGROUND The CSF of patients with LMD have an innate, but not adaptive, immune cellular profile. Murine LMD models showed IT cDC1s were safe, induced a Th1 response (CD4+ > CD8+ T cell and B cell dependent), cured most HER2+ LMD, and …
View article: PREVALENCE AND DETERMINANTS OF COMMON CHILDHOOD ILLNESSES AMONG UNDER-FIVE CHILDREN IN SOMALILAND: INSIGHTS FROM A NATIONWIDE SURVEY.
PREVALENCE AND DETERMINANTS OF COMMON CHILDHOOD ILLNESSES AMONG UNDER-FIVE CHILDREN IN SOMALILAND: INSIGHTS FROM A NATIONWIDE SURVEY. Open
View article: Evaluation of Dyeing Properties of Lawsonia Inermis on Multi-Fibers through the Exhaust Method
Evaluation of Dyeing Properties of Lawsonia Inermis on Multi-Fibers through the Exhaust Method Open
View article: Mental well‐being in prostate cancer: A multi‐institutional prospective cohort study
Mental well‐being in prostate cancer: A multi‐institutional prospective cohort study Open
Objective To investigate the patient, treatment and oncological prognostic factors for multiple mental well‐being outcomes in prostate cancer. Patient and Methods The MIND‐P study was a multi‐institutional prospective cohort study recruiti…
View article: Comparison of Cut-Off Value of Neutrophil to Lymphocyte Ratio in the Diagnosis of Non-Perforated Versus Perforated Appendix
Comparison of Cut-Off Value of Neutrophil to Lymphocyte Ratio in the Diagnosis of Non-Perforated Versus Perforated Appendix Open
Neutrophil-To-Lymphocyte Ratio (NLR) gives diagnostic clue about non-perforated and perforated appendixes. However, there are many variations in its cut-off values in diagnosis of non-perforated and perforated appendixes, and there is no s…
View article: Prevalence of Depression and Anxiety among Chronic Illness Patients in a Tertiary Care Hospital
Prevalence of Depression and Anxiety among Chronic Illness Patients in a Tertiary Care Hospital Open
Background: Chronic illnesses are increasingly prevalent worldwide and often coexist with psychological disorders such as depression and anxiety, which negatively impact patients’ quality of life, treatment adherence, and clinical outcomes…
View article: Iris mesenchymal tumour in an infant
Iris mesenchymal tumour in an infant Open
View article: Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials
Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials Open
Background: More than 160,000 skin grafts are performed annually in approximately 1 out of every 3 burn hospitalizations individually because they are primarily simple and quick. This network meta-analysis aimed to compare different conven…
View article: Force variability and neural control differences in an upper and lower limb muscle
Force variability and neural control differences in an upper and lower limb muscle Open
This study provides a unique, comprehensive comparison of the control of force and motor unit firing rates between a muscle in the upper and lower limb, and between sexes. Our findings identify differences in neural control between muscles…
View article: Empirical Study: Assessment in STEM Education: Principles, Policy & Practice and Formative Assessment in Punjab: A Collaborative Lineage
Empirical Study: Assessment in STEM Education: Principles, Policy & Practice and Formative Assessment in Punjab: A Collaborative Lineage Open
View article: Response to comments
Response to comments Open
View article: Residual stone fragments: systematic review of definitions, diagnostic standards
Residual stone fragments: systematic review of definitions, diagnostic standards Open
Purpose Residual stone fragments (RSFs) remain a determining factor for evaluation of outcome an intervention for management of renal tract stones. However, there is a lack of consensus on size, location, diagnosis and management of RSF. T…
View article: Environmental sustainability in urologic practices: a systematic review
Environmental sustainability in urologic practices: a systematic review Open
Purpose The aim of this systematic review is to assess the environmental impact of urologic procedures and equipment (P), specifically comparing emissions and waste generation between single-use and reusable devices (I and C), while also e…
View article: Oral Health Awareness and Practices among Libyan University Students: Insights into Non-Bacterial Tooth Wear
Oral Health Awareness and Practices among Libyan University Students: Insights into Non-Bacterial Tooth Wear Open
Background: Tooth substance loss, when unrelated to bacterial activity, encompasses several conditions such as attrition, abrasion, erosion, and resorption. Each of these forms of tooth wear results from different etiological factors, incl…
View article: Prevalence of Stress-induced Xerostomia among Libyan Students: A Cross-sectional Study on Exam-related Stress and Its Impact on Oral Health
Prevalence of Stress-induced Xerostomia among Libyan Students: A Cross-sectional Study on Exam-related Stress and Its Impact on Oral Health Open
Objectives: This cross-sectional study aimed to investigate the prevalence of stressinduced xerostomia among Libyan students during exam periods and explore its association with academic-related stress. Materials and Methods: A total of 70…
View article: Assessing Knowledge, Skills, and Attitudes of Nursing Leaders in Government Hospitals of Kurdistan, Iraq
Assessing Knowledge, Skills, and Attitudes of Nursing Leaders in Government Hospitals of Kurdistan, Iraq Open
View article: An Automated Robotic Process with Clinician Validation Enhances End-of-Life Registration Accuracy
An Automated Robotic Process with Clinician Validation Enhances End-of-Life Registration Accuracy Open
View article: The Role of Antihistamines in Dental Sedation: Perceptions and Practices among Dentists: A Cross-sectional Study
The Role of Antihistamines in Dental Sedation: Perceptions and Practices among Dentists: A Cross-sectional Study Open
Objectives: This study aims to explore the prevalence, reasons for use, dosage adjustments, and dentists' perceptions regarding antihistamines in dental sedation. Methods: A cross-sectional survey was conducted among 150 dentists. Particip…
View article: Red Blood Cell Parameters among Malnourished Children Under-Five Years Attending Al-Sadaqa Teaching Hospital, Aden-Yemen
Red Blood Cell Parameters among Malnourished Children Under-Five Years Attending Al-Sadaqa Teaching Hospital, Aden-Yemen Open
Malnutrition means deficiencies or inadequate nutrients as well as excesses or imbalances of nutrients intake by the individuals. This study was aimed to determine the abnormal Red blood cell parameters among malnourished children underـfi…
View article: Improving event prediction using general practitioner clinical judgement in a digital risk stratification model: a pilot study
Improving event prediction using general practitioner clinical judgement in a digital risk stratification model: a pilot study Open
Background Numerous tools based on electronic health record (EHR) data that predict risk of unscheduled care and mortality exist. These are often criticised due to lack of external validation, potential for low predictive ability and the u…
View article: Science education curriculum implementation: Classroom instruction perspectives in middle-level schools of eastern Ethiopia
Science education curriculum implementation: Classroom instruction perspectives in middle-level schools of eastern Ethiopia Open
This study investigates the implementation of the Science Education Curriculum through classroom instruction in middle-level schools in Eastern Ethiopia. A mixed-methods research design was employed for data collection. Quantitative data w…
View article: Modelling and forecasting of monthly extreme temperature using MLE and L-moment estimation methods: Khyber Pakhtunkhwa, Pakistan
Modelling and forecasting of monthly extreme temperature using MLE and L-moment estimation methods: Khyber Pakhtunkhwa, Pakistan Open
Extreme Events Analysis (EEA) is an essential tool for the designing and policy-making of rare events occurrence and infrastructure epically in Climate Change (CC). The results of EEA can be used to predict the magnitude and frequency of e…