Kamruddin Ahmed
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View article: Seroprevalence and Molecular Detection of Coxsackie B Virus among Patients With Diabetes Type-1 In Jigawa State
Seroprevalence and Molecular Detection of Coxsackie B Virus among Patients With Diabetes Type-1 In Jigawa State Open
Type-1 diabetes (T1D) pathogenesis is either initiated or accelerated by human enteroviruses, particularly Coxsackie viruses. Because the structural makeup of the virus's viral protein 2 C (P2-C) and the glutamic acid decarboxylase (GAD65)…
View article: Genomic analysis and molecular profiling of dengue viruses in Sabah, Malaysia during 2019-2020
Genomic analysis and molecular profiling of dengue viruses in Sabah, Malaysia during 2019-2020 Open
To the best of our knowledge, this study provides the first detailed phylogenetic and complete genome analysis of DENV in Sabah. Continued molecular surveillance is essential to enhance our understanding of dengue transmission and support …
View article: Prevalence of chikungunya virus infection in Sabah, Malaysia during 2017–2020
Prevalence of chikungunya virus infection in Sabah, Malaysia during 2017–2020 Open
Background Chikungunya virus (CHIKV) is a mosquito-borne alphavirus and an emerging global health threat. Most research on CHIKV in Malaysia has primarily focused on Peninsular Malaysia, with limited data on its distribution in the endemic…
View article: Two Novel Resazurin Derivatives, R-mor and R-MeAll, Exhibit Robust Antimicrobial Activity Against Neisseria gonorrhoeae.
Two Novel Resazurin Derivatives, R-mor and R-MeAll, Exhibit Robust Antimicrobial Activity Against Neisseria gonorrhoeae. Open
Antibiotic resistance is an urgent public health threat. The CDC estimates there are approximately 2.8 million new cases of antibiotic-resistant infections annually resulting in 35,000 deaths and billions of dollars in health care costs. T…
View article: Mathematical Modeling and Computational Tools for Efficient Water Resource Management: Optimizing Allocation and Sustainability
Mathematical Modeling and Computational Tools for Efficient Water Resource Management: Optimizing Allocation and Sustainability Open
Worldwide, this is an important issue of managing water resources with the need for effective distribution and sustainable use. The processes of mathematical modeling and computational techniques of water distribution which include Genetic…
View article: Environmental Variations and Mycotoxin Dynamics: Impacts on Structure Toxicity and Health Risks
Environmental Variations and Mycotoxin Dynamics: Impacts on Structure Toxicity and Health Risks Open
Mycotoxins are dangerous secondary metabolites produced by fungi, such as Aspergillus, Penicillium, and Fusarium, that pose serious health as well as ecological risks, since they are stable and adaptive in a variety of environments. These …
View article: Emergence of non-classical genotype constellations of G9P[8] rotavirus strains in diarrheic children in Sabah, Malaysia
Emergence of non-classical genotype constellations of G9P[8] rotavirus strains in diarrheic children in Sabah, Malaysia Open
G9P[8] has been the predominant rotavirus A (RVA) genotype in Malaysia since the 2000s. However, the overall genetic makeup and evolution of Malaysian G9P[8] strains are still unknown. Therefore, this study aimed to evaluate and characteri…
View article: Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats
Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats Open
Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 infection have been reported in Malay…
View article: STUDIES ON THE IMMUNE RESPONSE OF RABBITS VACCINATED WITH P. MULTOCIDA AND TETANUS TOXOID
STUDIES ON THE IMMUNE RESPONSE OF RABBITS VACCINATED WITH P. MULTOCIDA AND TETANUS TOXOID Open
View article: Exploring community participation in vectorborne disease control in Southeast Asia: a scoping review protocol
Exploring community participation in vectorborne disease control in Southeast Asia: a scoping review protocol Open
Introduction Vector borne diseases (VBDs) present significant public health challenges in Southeast Asia (SEA), and the increasing number of cases threatens vulnerable communities. Inadequate vector control and management have been linked …
View article: Frequency of Rotavirus and Adenovirus in Turkish and Immigrant Patients with Acute Gastroenteritis
Frequency of Rotavirus and Adenovirus in Turkish and Immigrant Patients with Acute Gastroenteritis Open
Objective: The objective of this study was to investigate the prevalence and seasonal distribution of rotavirus and enteric adenovirus in patients with acute gastroenteritis. Methods: The results of 2960 patients admitted to Ankara Trainin…
View article: Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza
Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza Open
Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 infection have been reported in Malay…
View article: Meguro Parasitological Museum – A Wonderful Experience Full of Surprises
Meguro Parasitological Museum – A Wonderful Experience Full of Surprises Open
In November 2023, one of us had the opportunity to visit the Meguro Parasitological Museum in Tokyo, Japan. The museum started its journey in 1953 with private funding from Dr Satoru Kamgeai. Now, the museum is a 70-year-old private resear…
View article: Knowledge, compliance, and challenges in anti-malarial products usage: a systematic review of at-risk communities for zoonotic malaria
Knowledge, compliance, and challenges in anti-malarial products usage: a systematic review of at-risk communities for zoonotic malaria Open
View article: IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors
IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors Open
Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasia associated with human T-cell leukemia virus type 1 (HTLV-1) infection and has an extremely poor prognosis. Lenalidomide (LEN; a second-generation immunomodulatory drug …
View article: First Whole Genome Sequencing Data of a Mycobacterium Tuberculosis Stb-T1a Strain Isolated from a Spinal Tuberculosis Patient in Sabah, Malaysia
First Whole Genome Sequencing Data of a Mycobacterium Tuberculosis Stb-T1a Strain Isolated from a Spinal Tuberculosis Patient in Sabah, Malaysia Open
View article: Leptospirosis in Malaysia: current status, insights, and future prospects
Leptospirosis in Malaysia: current status, insights, and future prospects Open
Among zoonotic infections, leptospirosis has a worldwide distribution and high prevalence in tropical regions. It has a broad clinical presentation from mild to severe, life-threatening infection. Leptospires, the etiological agent of lept…
View article: Emergence of equine‐like G3 and porcine‐like G9 rotavirus strains in Sarawak, Malaysia: 2019−2021
Emergence of equine‐like G3 and porcine‐like G9 rotavirus strains in Sarawak, Malaysia: 2019−2021 Open
Rotavirus is the leading causative viral agent of pediatric acute gastroenteritis globally, infecting mostly children 5 years old and below. Data on rotavirus prevalence in Malaysia is scarce, despite the WHO's recommendation for continuou…
View article: Simian malaria: a narrative review on emergence, epidemiology and threat to global malaria elimination
Simian malaria: a narrative review on emergence, epidemiology and threat to global malaria elimination Open
View article: Exploring barriers to and facilitators of malaria prevention practices: a photovoice study with rural communities at risk to Plasmodium knowlesi malaria in Sabah, Malaysia
Exploring barriers to and facilitators of malaria prevention practices: a photovoice study with rural communities at risk to Plasmodium knowlesi malaria in Sabah, Malaysia Open
View article: The One Health Approach to Addressing Zoonotic Malaria in Rural Northern Borneo: Challenges and Solutions
The One Health Approach to Addressing Zoonotic Malaria in Rural Northern Borneo: Challenges and Solutions Open
Plasmodium knowlesi malaria is a vector-borne disease transmitted by the Anopheles mosquito. The incidence of this zoonotic malaria in South-east Asian rural communities continues to increase annually, despite efforts and guidelines for ma…
View article: API Management and Governance Model for Large-Scale SaaS Solutions
API Management and Governance Model for Large-Scale SaaS Solutions Open
Application Programming Interfaces (APIs) have become the backbone of modern Software-as-a-Service (SaaS) platforms, enabling seamless integration, interoperability, and extensibility across complex, multi-tenant environments. As SaaS solu…
View article: Generating Trust in Participatory Research on Plasmodium knowlesi Malaria: A Study with Rural Community Gatekeepers during the COVID-19 Pandemic
Generating Trust in Participatory Research on Plasmodium knowlesi Malaria: A Study with Rural Community Gatekeepers during the COVID-19 Pandemic Open
Background: Plasmodium knowlesi malaria is a zoonotic infection that affects rural communities in South East Asia. Although the epidemiology of the disease has been extensively researched, the voices of individuals within affected communit…
View article: No evidence of sustained nonzoonotic Plasmodium knowlesi transmission: estimating species-specific spatiotemporally varying reproduction numbers for malaria in Malaysia
No evidence of sustained nonzoonotic Plasmodium knowlesi transmission: estimating species-specific spatiotemporally varying reproduction numbers for malaria in Malaysia Open
Reported incidence of the zoonotic malaria Plasmodium knowlesi has markedly increased across Southeast Asia and threatens malaria elimination. Nonzoonotic transmission of P. knowlesi has been experimentally demonstrated, but it remains unk…
View article: A Retrospective Review of Global Commercial Seaweed Production—Current Challenges, Biosecurity and Mitigation Measures and Prospects
A Retrospective Review of Global Commercial Seaweed Production—Current Challenges, Biosecurity and Mitigation Measures and Prospects Open
Commercial seaweed cultivation has undergone drastic changes to keep up with the increasing demand in terms of the quantity and quality of the algal biomass needed to meet the requirements of constant innovation in industrial applications.…
View article: Systematic review of Plasmodium knowlesi in Indonesia: a risk of emergence in the context of capital relocation to Borneo?
Systematic review of Plasmodium knowlesi in Indonesia: a risk of emergence in the context of capital relocation to Borneo? Open
Background The Indonesian Republic plans to relocate its capital from Jakarta to East Kalimantan, Borneo Island in the next few years. This relocation may be associated with deforestation, decreased biodiversity and an increased risk of em…
View article: Reimagining zoonotic malaria control in communities exposed to Plasmodium knowlesi infection
Reimagining zoonotic malaria control in communities exposed to Plasmodium knowlesi infection Open
Plasmodium knowlesi malaria infection in humans has been reported throughout southeast Asia. The communities at risk are those living in areas where Macaque monkeys and Anopheles mosquito are present. Zoonotic malaria control is challengin…
View article: A 1-year cross-sectional study on the predominance of influenza among hospitalized children in a tropical area, Kota Kinabalu, Sabah
A 1-year cross-sectional study on the predominance of influenza among hospitalized children in a tropical area, Kota Kinabalu, Sabah Open
Background Children are at higher risk of influenza virus infection, and it is difficult to diagnose. They are also responsible for the transmission of influenza because of their longer viral shedding compared to adults. In Malaysia, studi…
View article: Serological Evidence of Zika Virus Infection in Febrile Patients and Healthy Blood Donors in Sabah, Malaysian Borneo, 2017–2018
Serological Evidence of Zika Virus Infection in Febrile Patients and Healthy Blood Donors in Sabah, Malaysian Borneo, 2017–2018 Open
Several Zika virus (ZIKV) seroprevalence studies have been conducted in Africa, Asia, Oceania, the Americas, and the Caribbean. However, studies on ZIKV seroprevalence are limited in Malaysia though several studies have shown that the dise…
View article: Investigation of Group A Rotavirus G10, G12 Genotypes Emerging in Patients with Acute Gastroenteritis in a Tertiary Care Hospital
Investigation of Group A Rotavirus G10, G12 Genotypes Emerging in Patients with Acute Gastroenteritis in a Tertiary Care Hospital Open
Rotaviruses are the most common cause of viral gastroenteritis with the highest mortality and morbidity rates in children aged 0-5 years. The aim of this study was to determine the frequency of rotavirus infection in patients whose stool s…