Karen H. Lu
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Enzyme‐Linked Immunosorbent Assay‐Derived Methods for Biomarker Detection Open
Enzyme‐linked immunosorbent assay (ELISA) has become an indispensable tool for biomarker detection in clinical diagnosis owing to its high specificity, sensitivity, and throughput. However, the sensitivity of conventional ELISA remains ins…
View article: Supplementary Figure S2 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Figure S2 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Figure S2 Transcriptomic level comparisons of the tumor compartment between MRD and IDS samples using GeoMx data. (A) Volcano plot showing DEGs between the tumor compartment of MRD and IDS samples, with genes related to hypox…
View article: Supplementary Table S4 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Table S4 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Table S4. Clinical Information of Translational Samples
View article: Supplementary Table S3 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Table S3 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Table S3. Multivariable Analysis of Prognostic Factors for Progression-Free Survival
View article: Data from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Data from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Purpose:Minimal residual disease (MRD) after first-line treatment of advanced-stage ovarian cancer remains a long-standing barrier to cure. We investigated the prognostic and translational value of MRD detection by second-look laparoscopy …
View article: Supplementary Figure S1 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Figure S1 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Figure S1 Clinical management of patients in the study cohort following SLL. *Many of these patients had the HRD assay performed retroactively on archival tissue and in this case, HRD status was not known in the upfront maint…
View article: Supplementary Table S2 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Table S2 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Table S2. Demographic and Clinical Characteristics for Patients Who Underwent Second Look Laparoscopy and Circulating Tumor DNA (ctDNA) Analysis
View article: Supplementary Figure S3 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Figure S3 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Figure S3 Clinical courses of MRD+ cases and tumor expression profiles in MRD lesions. (A) The expression of potential therapeutic targets and genes of interest in the tumor region of sample 3A, the MRD sample from Pt-10. (B)…
View article: Supplementary Table S1 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Table S1 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Table S1. CODEX Panel
View article: Supplementary Figure S4 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Figure S4 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Figure S4 Immune exclusion in the SLL sample 6B revealed by orthogonal spatial profiling. (A) CODEX profiling revealed two representative regions in the MRD sample (6B) of Pt-67. Region 1 located in the tumor margin where tum…
View article: Supplementary Table S5 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Supplementary Table S5 from Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Supplementary Table S5. Progressively Upregulated or Downregulated Genes in the Tumor Compartment of MRD+ Cases
View article: Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities
Surgical and Blood-Based Minimal Residual Disease in Patients with Ovarian Cancer after First-line Therapy: Clinical Outcomes and Translational Opportunities Open
Purpose: Minimal residual disease (MRD) after first-line treatment of advanced-stage ovarian cancer remains a long-standing barrier to cure. We investigated the prognostic and translational value of MRD detection by second-look laparoscopy…
View article: Data from Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women
Data from Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women Open
Levonorgestrel-releasing intrauterine system (LNG-IUS) use is approved by the FDA for contraception and heavy menorrhagia. More importantly, it effectively treats endometrial hyperplasia, a precursor to endometrial cancer. Therefore, LNG-I…
View article: Supplemental Table 1 from Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women
Supplemental Table 1 from Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women Open
Supplemental Table 1 shows the sociodemographic and medical history characteristics of the NSFG sample as stratified by race/ethnic groups.
View article: Supplemental Table 3 from Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women
Supplemental Table 3 from Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women Open
Supplemental Table 3 shows the association of demographic and health predictors on current LNG-IUS use as stratified by race/ethnic groups.
View article: Supplemental Table 2 from Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women
Supplemental Table 2 from Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women Open
Supplemental Table 2 shows the weighted prevalence of LNG-IUS use by different sociodemographic characteristics as stratified by race/ethnic groups.
View article: SCORE: Story Coherence and Retrieval Enhancement for AI Narratives
SCORE: Story Coherence and Retrieval Enhancement for AI Narratives Open
Large Language Models (LLMs) can generate creative and engaging narratives from user-specified input, but maintaining coherence and emotional depth throughout these AI-generated stories remains a challenge. In this work, we propose SCORE, …
View article: Guiding chili variety selection for Zao chili in Guizhou: Based on a systematic study of sensory, physicochemical, and volatile characteristics
Guiding chili variety selection for Zao chili in Guizhou: Based on a systematic study of sensory, physicochemical, and volatile characteristics Open
This work investigated the influence of seven chili varieties in Guizhou on the quality of Zao Chili (ZC), a local traditional fermented chili product. The physical and chemical indicators, volatile components, and product quality of the s…
View article: Do Patients with Prior Distraction Arthroplasty Fare Worse after Total Ankle Replacement?
Do Patients with Prior Distraction Arthroplasty Fare Worse after Total Ankle Replacement? Open
Submission Type: Total Ankle Arthroplasty Research Type: Level 4 – Case series Introduction/Purpose: Distraction arthroplasty aims to treat ankle osteoarthritis while preserving the native ankle joint, with the goal to prevent or delay ank…
View article: Correcting Tibiotalar Alignment Correlates with FAO Changes after Total Ankle Replacement
Correcting Tibiotalar Alignment Correlates with FAO Changes after Total Ankle Replacement Open
Submission Type: Ankle Arthritis Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: Re-establishing anatomic ankle and foot alignment is critical to optimize clin…
View article: Sagittal Alignment May Not Correlate with Range of Motion in Ankle Arthritis and TAR
Sagittal Alignment May Not Correlate with Range of Motion in Ankle Arthritis and TAR Open
Submission Type: Ankle Arthritis Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: Improving range of motion (ROM) is one of the most challenging objectives in t…
View article: Correction: Immune environment and antigen specificity of the T cell receptor repertoire of malignant ascites in ovarian cancer
Correction: Immune environment and antigen specificity of the T cell receptor repertoire of malignant ascites in ovarian cancer Open
[This corrects the article DOI: 10.1371/journal.pone.0279590.].
View article: Supplementary Table S3 from Long-Term Follow-up of Levonorgestrel Intrauterine Device for Atypical Hyperplasia and Early Endometrial Cancer Reveals Relapse Characterized by Immune Exhaustion
Supplementary Table S3 from Long-Term Follow-up of Levonorgestrel Intrauterine Device for Atypical Hyperplasia and Early Endometrial Cancer Reveals Relapse Characterized by Immune Exhaustion Open
Supplementary Table S3. Digital spatial profiling log2-normalized gene expression data.