Kana Mizuno
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View article: A simple, efficient, and scalable method to generate oocyte-like cells in vitro
A simple, efficient, and scalable method to generate oocyte-like cells in vitro Open
Understanding the molecular basis of oocyte identity and function is essential not only for basic biology but also for clinical applications, as it is closely linked to female infertility. However, technical challenges remain in advancing …
View article: Interferon-induced cell senescence as a novel mechanism of eculizumab resistance in transplant associated thrombotic microangiopathy
Interferon-induced cell senescence as a novel mechanism of eculizumab resistance in transplant associated thrombotic microangiopathy Open
Eculizumab significantly increased survival in patients with transplant associated thrombotic microangiopathy (TA-TMA), however one third of TA-TMA patients still die despite prompt treatment with eculizumab. The mechanism of eculizumab re…
View article: Precision Alemtuzumab Dosing Results in Day 0 Target Range Achievement in 80% of IEI Patients and Minimizes Risks of GVHD, Clinically Significant Mixed Chimerism, and Secondary Graft Failure
Precision Alemtuzumab Dosing Results in Day 0 Target Range Achievement in 80% of IEI Patients and Minimizes Risks of GVHD, Clinically Significant Mixed Chimerism, and Secondary Graft Failure Open
Introduction Reduced intensity and reduced toxicity conditioning regimens offer low rates of toxicities and superior survival for patients with inborn errors of immunity undergoing allogeneic HCT. However, these approaches can be associate…
View article: Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia
Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia Open
Fanconi anemia (FA) is a rare inherited disorder characterized by progressive bone marrow failure (BMF) and a predisposition to malignancy. Systemic reactive oxygen species (ROS) and increased sensitivity of FA hematopoietic progenitors to…
View article: Adopting Model‐Informed Precision‐Dosing for Eculizumab in Transplant Associated‐Thrombotic Microangiopathy to Gene Therapies
Adopting Model‐Informed Precision‐Dosing for Eculizumab in Transplant Associated‐Thrombotic Microangiopathy to Gene Therapies Open
Gene therapy advances offer great hope to previously uncurable disorders but come with a steep learning curve to assure safety and therapeutic success. Thrombotic microangiopathy (TMA) is a life-threatening complement-mediated vasculopathy…
View article: Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT
Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT Open
Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal posttransplant complication of hematopoietic stem cell transplantation. We recently reported that survival for TA-TMA has been improved by early intervention with eculizu…
View article: Erythema nodosum and sarcoidosis
Erythema nodosum and sarcoidosis Open
我々は心臓サルコイドーシス(心サ症)の診療および臨床研究に 10年以上従事し,国内外の専門誌に研究成果を発表してきた.まず,画像的検討に関して,心臓外サ症におけるガドリニウム遅延造影心臓 MRIを用いて検出した心臓微小病変は平均 50ヵ月の有害事象発生と関連しない可能性を示した.また,疫学的検討として心サ症診断時の免疫抑制療法の導入が長期にわたり心機能を保持し,心不全入院を抑制していたことを明らかにした.その上,免疫抑制療法が開始され,その後安定した経過をたどり免疫抑制療法…
View article: Test‐dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non‐malignant disorders
Test‐dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non‐malignant disorders Open
Aims We studied melphalan pharmacokinetics (PK) and feasibility of melphalan full‐dose adjustment based on test‐dose PK in children and young adults with non‐malignant disorders (NMD) undergoing allogeneic hematopoietic cell transplantatio…
View article: Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines
Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines Open
Purpose Noonan syndrome with multiple lentigines (NSML) is an autosomal dominant disorder presenting with hypertrophic cardiomyopathy (HCM). Up to 85% of NSML cases are caused by mutations in the PTPN11 gene that encodes for the Src homolo…
View article: Paperspray Ionization Mass Spectrometry as a Tool for Predicting Real-Time Optimized Dosing of the Chemotherapeutic Drug Melphalan
Paperspray Ionization Mass Spectrometry as a Tool for Predicting Real-Time Optimized Dosing of the Chemotherapeutic Drug Melphalan Open
Background Melphalan, an important component of hematopoietic stem cell transplantation (HSCT) preparative regimens, is associated with significant toxicity and large between patient variability in pharmacokinetics making it difficult to c…
View article: Complement blockade for TA-TMA: lessons learned from large pediatric cohort treated with eculizumab
Complement blockade for TA-TMA: lessons learned from large pediatric cohort treated with eculizumab Open
Overactivated complement is a high-risk feature in HSCT recipients with transplant associated thrombotic microangiopathy (TA-TMA), and untreated patients have dismal outcomes. We present our experience of 64 pediatric HSCT recipients with …
View article: Pharmacokinetics and Pharmacodynamics Estimation of Eculizumab in a 2-Year-Old Girl With Atypical Hemolytic Uremic Syndrome: A Case Report With 4-Year Follow-Up
Pharmacokinetics and Pharmacodynamics Estimation of Eculizumab in a 2-Year-Old Girl With Atypical Hemolytic Uremic Syndrome: A Case Report With 4-Year Follow-Up Open
Background: Eculizumab has dramatically changed poor outcomes of complement-mediated atypical hemolytic uremic syndrome (aHUS) as first-line treatment. Discontinuation of eculizumab remains challenging, and doctor's visits every 2 weeks fo…
View article: Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner
Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner Open
Nε-(carboxymethyl) lysine (CML), an advanced glycation end product (AGE), is an aging factor produced by glycation of protein.Higher levels of AGE in skin tissue are related to skin elasticity, but how CML that has accumulated in the skin …
View article: TARC expression in the circulation and cutaneous granulomas correlates with disease severity and indicates Th2-mediated progression in patients with sarcoidosis
TARC expression in the circulation and cutaneous granulomas correlates with disease severity and indicates Th2-mediated progression in patients with sarcoidosis Open
The present results suggest that elevations in TARC drive an imbalanced Th2- weighted immune reaction and might facilitate prolonged inflammatory reactions in sarcoidosis.
View article: Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study
Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study Open
Micafungin at 5 mg/kg dosing did not achieve target attainment at the end of 96 h for antifungal prophylaxis in children undergoing HSCT. Simulation data suggest that a dosing strategy of micafungin at 5 mg/kg every 72 h is more likely to …
View article: Fulvic acid-induced mitochondrial membrane potential improves diabetic symptoms in mice
Fulvic acid-induced mitochondrial membrane potential improves diabetic symptoms in mice Open
Type 2 diabetes has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but are not effective in correcting its underlying cause. One important causal factor of type 2 diabetes is…
View article: Test Dose Pharmacokinetics to Predict Melphalan Dosing in Children Undergoing Hematopoietic Stem Cell Transplant (HSCT) with Organ Impairment☆
Test Dose Pharmacokinetics to Predict Melphalan Dosing in Children Undergoing Hematopoietic Stem Cell Transplant (HSCT) with Organ Impairment☆ Open
Background: Melphalan is commonly used in reduced intensity conditioning (RIC) regimens in children undergoing allogeneic HSCT for non-malignant disorders and causes toxicity. Pharmacokinetic (PK) data for melphalan in children are limited…
View article: A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses
A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses Open
Maraviroc is an allosteric small molecule antagonist of chemokine receptor type 5 (CCR5) and has been used in adult allogeneic hematopoietic stem cell transplant (HSCT) recipients to prevent acute graft-versus-host disease (GVHD) of the ga…
View article: Obesity and overweight as CAE comorbidities and differential drug response modifiers
Obesity and overweight as CAE comorbidities and differential drug response modifiers Open
Overweight and obesity are more prevalent in children with newly diagnosed CAE than in age-matched peers, despite lower caloric and carbohydrate intake. Baseline BMI may also predict differential drug response, which cannot be attributed t…
View article: Phase 1 Study of Maraviroc As Acute Graft-Versus-Host Disease Prophylaxis in Pediatrics
Phase 1 Study of Maraviroc As Acute Graft-Versus-Host Disease Prophylaxis in Pediatrics Open
CCR5 is a chemokine receptor on activated effector T-cells, known to play a role in lymphocyte trafficking to the GI tract and liver. Maraviroc is an allosteric small molecule antagonist of CCR5 and has been used in adult allogeneic hemato…