Kanade Tatsumi
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View article: CRISPR/Cas9-mediated genome editing reveals the involvement of a polyphenol oxidase in the shikonin-specific biosynthesis in <i>Lithospermum erythrorhizon</i>
CRISPR/Cas9-mediated genome editing reveals the involvement of a polyphenol oxidase in the shikonin-specific biosynthesis in <i>Lithospermum erythrorhizon</i> Open
Shikonin, a 1,4-naphthoquinone derivative produced by several Boraginaceae species, exhibits unique pharmacological properties and is used as a natural dye. The regulatory factors of shikonin production have been demonstrated using a cell …
View article: Benzo-fused ten-membered ring meroterpenoids: sources, chemical diversity, biological activities, and biosynthesis
Benzo-fused ten-membered ring meroterpenoids: sources, chemical diversity, biological activities, and biosynthesis Open
Meroterpenoids, a class of hybrid natural products derived from both terpenoid and non-terpenoid biosynthetic pathways, serve as a prolific source of drug leads, because of their structural complexity and extensive bioactivities. Meroterpe…
View article: Peroxisomal 4-coumaroyl-CoA ligases participate in shikonin production in <i>Lithospermum erythrorhizon</i>
Peroxisomal 4-coumaroyl-CoA ligases participate in shikonin production in <i>Lithospermum erythrorhizon</i> Open
4-Coumaroyl-CoA ligase (4CL) is a key enzyme in the phenylpropanoid pathway, which is involved in the biosynthesis of various specialized metabolites such as flavonoids, coumarins, lignans, and lignin. Plants have several 4CLs showing dive…
View article: An ancient role for the<i>CYP73</i>gene family in<i>t</i>-cinnamic acid 4-hydroxylation, phenylpropanoid biosynthesis and embryophyte development
An ancient role for the<i>CYP73</i>gene family in<i>t</i>-cinnamic acid 4-hydroxylation, phenylpropanoid biosynthesis and embryophyte development Open
The phenylpropanoid pathway is a plant metabolism intimately linked to the transition to terrestrial life. It produces phenolic compounds that play essential roles in stress mitigation and ecological interactions. The pathway also provides…
View article: Characterization of Arnebia euchroma PGT homologs involved in the biosynthesis of shikonin
Characterization of Arnebia euchroma PGT homologs involved in the biosynthesis of shikonin Open
Shikonin is a red naphthoquinone natural product from plants with high economical and medical values. The para-hydroxybenzoic acid geranyltransferase (PGT) catalyzes the key regulatory step of shikonin biosynthesis. PGTs from Lithospermum …
View article: Excretion of triacylglycerol as a matrix lipid facilitating apoplastic accumulation of a lipophilic metabolite shikonin
Excretion of triacylglycerol as a matrix lipid facilitating apoplastic accumulation of a lipophilic metabolite shikonin Open
SUMMARY Plants produce a large variety of lipophilic metabolites, many of which are secreted by cells and accumulated in apoplasts. The mechanism of secretion remains largely unknown, because hydrophobic metabolites, which may form oil dro…
View article: Parallel evolution of UbiA superfamily proteins into aromatic <i>O</i> -prenyltransferases in plants
Parallel evolution of UbiA superfamily proteins into aromatic <i>O</i> -prenyltransferases in plants Open
Significance Plants produce approximately 300 O -prenylated aromatics, with their O -prenyl moieties often being crucial to their bioactivities. This study identified a gene from grapefruit encoding an aromatic O -prenyltransferase ( O- PT…
View article: Function of the HYDROXYCINNAMOYL-CoA:SHIKIMATE HYDROXYCINNAMOYL TRANSFERASE is evolutionarily conserved in embryophytes
Function of the HYDROXYCINNAMOYL-CoA:SHIKIMATE HYDROXYCINNAMOYL TRANSFERASE is evolutionarily conserved in embryophytes Open
The plant phenylpropanoid pathway generates a major class of specialized metabolites and precursors of essential extracellular polymers that initially appeared upon plant terrestrialization. Despite its evolutionary significance, little is…
View article: Function of the HYDROXYCINNAMOYL-CoA:SHIKIMATE HYDROXYCINNAMOYL TRANSFERASE is evolutionarily conserved in embryophytes
Function of the HYDROXYCINNAMOYL-CoA:SHIKIMATE HYDROXYCINNAMOYL TRANSFERASE is evolutionarily conserved in embryophytes Open
The plant phenylpropanoid pathway generates a major class of specialized metabolites and precursors of essential extracellular polymers that initially appeared upon plant terrestrialization. Despite its evolutionary significance, little is…
View article: Parallel evolution of UbiA superfamily proteins into aromatic<i>O</i>-prenyltransferases in plants
Parallel evolution of UbiA superfamily proteins into aromatic<i>O</i>-prenyltransferases in plants Open
Plants produce approximately 300 aromatic molecules enzymatically linked to prenyl side chains via C-O bonds. These O -prenylated aromatics have been found in taxonomically distant plant taxa as compounds beneficial or detrimental to human…
View article: Highly efficient method of <i>Lithospermum erythrorhizon</i> transformation using domestic <i>Rhizobium rhizogenes</i> strain A13
Highly efficient method of <i>Lithospermum erythrorhizon</i> transformation using domestic <i>Rhizobium rhizogenes</i> strain A13 Open
Lithospermum erythrorhizon, a medicinal plant growing in Asian countries, produces shikonin derivatives that are lipophilic secondary metabolites. These red naphthoquinone pigments are traditionally used as a natural drug and a dye in East…
View article: A Cytosol-Localized Geranyl Diphosphate Synthase from <i>Lithospermum erythrorhizon</i> and Its Molecular Evolution
A Cytosol-Localized Geranyl Diphosphate Synthase from <i>Lithospermum erythrorhizon</i> and Its Molecular Evolution Open
Geranyl diphosphate (GPP) is the direct precursor of all monoterpenoids and is the prenyl source of many meroterpenoids, such as geranylated coumarins. GPP synthase (GPPS) localized in plastids is responsible for providing the substrate fo…
View article: Convergent evolution of the UbiA prenyltransferase family underlies the independent acquisition of furanocoumarins in plants
Convergent evolution of the UbiA prenyltransferase family underlies the independent acquisition of furanocoumarins in plants Open
Summary Furanocoumarins (FCs) are plant‐specialized metabolites with potent allelochemical properties. The distribution of FCs is scattered with a chemotaxonomical tendency towards four distant families with highly similar FC pathways. The…
View article: Isolation of Artemisia capillaris membrane-bound di-prenyltransferase for phenylpropanoids and redesign of artepillin C in yeast
Isolation of Artemisia capillaris membrane-bound di-prenyltransferase for phenylpropanoids and redesign of artepillin C in yeast Open
Plants produce various prenylated phenolic metabolites, including flavonoids, phloroglucinols, and coumarins, many of which have multiple prenyl moieties and display various biological activities. Prenylated phenylpropanes, such as artepil…
View article: Characterization of Shikonin Derivative Secretion in Lithospermum erythrorhizon Hairy Roots as a Model of Lipid-Soluble Metabolite Secretion from Plants
Characterization of Shikonin Derivative Secretion in Lithospermum erythrorhizon Hairy Roots as a Model of Lipid-Soluble Metabolite Secretion from Plants Open
Shikonin derivatives are specialized lipophilic metabolites, secreted in abundant amounts from the root epidermal cells of Lithospermum erythrorhizon. Because they have anti-microbial activities, these compounds, which are derivatives of r…