Kanaga Sabapathy
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View article: Mutant p53 Gain of Function: Why Many See It, Why Some Do Not
Mutant p53 Gain of Function: Why Many See It, Why Some Do Not Open
Summary: Mutations in the TP53 tumor-suppressor gene in human cancer are unique in that 60% to 70% are of the missense variety, resulting in a full-length protein that is often highly expressed in patients’ tumors. These missense mutant pr…
View article: Tumor suppressor genes in the tumor microenvironment
Tumor suppressor genes in the tumor microenvironment Open
Tumor suppressor genes (TSGs) are thought to suppress tumor development primarily via cancer cell-autonomous mechanisms. However, the tumor microenvironment (TME) also significantly influences tumorigenesis. In this context, a role for TSG…
View article: Targeting mutant p53: Evaluation of novel anti-p53 R175H monoclonal antibodies as diagnostic tools
Targeting mutant p53: Evaluation of novel anti-p53 R175H monoclonal antibodies as diagnostic tools Open
About 50 % of all cancers carry a mutation in p53 that impairs its tumor suppressor function. The p53 missense mutation p53R175H (p53R172H in mice) is a hotspot mutation in cancer and the germline of Li-Fraumeni syndrome patients. Therefor…
View article: Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73
Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73 Open
The transcription factor p73, a member of the p53 tumor-suppressor family, regulates cell death and also supports tumorigenesis, although the mechanistic basis for the dichotomous functions is poorly understood. We report here the identifi…
View article: Correction: Molecular characterization of hepatocarcinogenesis using mouse models
Correction: Molecular characterization of hepatocarcinogenesis using mouse models Open
An error was noted in Dis. Model. Mech. (2015) 8, dmm017624 (doi:10.1242/dmm.017624).The authors inadvertently transposed the mouse and human hepatocellular carcinoma (HCC) panels in Fig. 3E during figure assembly. The corrected figure pan…
View article: BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes
BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes Open
Hairy cell leukemia (HCL) is a B-lymphoma induced by BRAF(V600E) mutation. However, introducing BRAF(V600E) in B-lymphocytes fails to induce hematological malignancy, suggesting that BRAF(V600E) needs concurrent mutations to drive HCL onto…
View article: Editorial: Overcoming the cell membrane to target intracellular oncoproteins
Editorial: Overcoming the cell membrane to target intracellular oncoproteins Open
EDITORIAL article Front. Oncol., 12 July 2023Sec. Molecular and Cellular Oncology Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1222095
View article: EPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration
EPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration Open
Polyamines promote cellular proliferation. Their levels are controlled by ornithine decarboxylase antizyme 1 (Az1, encoded by OAZ1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the r…
View article: Supplementary figure from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism
Supplementary figure from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism Open
Supplemental Figure 1
View article: Supplemental Figure Legends from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism
Supplemental Figure Legends from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism Open
Supplementary Figure. 1A. Nuclear extracts (N.E.) from various serum-starved pancreatic cancer cell lines were probed for NF-κBbinding activity. Also included were serum-starved Panc-28 cells after stimulation by IL-1. Supershift assays we…
View article: Supplemental Figure Legends from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism
Supplemental Figure Legends from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism Open
Supplementary Figure. 1A. Nuclear extracts (N.E.) from various serum-starved pancreatic cancer cell lines were probed for NF-κBbinding activity. Also included were serum-starved Panc-28 cells after stimulation by IL-1. Supershift assays we…
View article: Data from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism
Data from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism Open
Activator protein-1 (AP-1) regulates the expression of several genes involved in human tumorigenesis. However, there is little known about this transcription factor in pancreatic ductal adenocarcinoma. We recently found high levels of AP-1…
View article: Data from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism
Data from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism Open
Activator protein-1 (AP-1) regulates the expression of several genes involved in human tumorigenesis. However, there is little known about this transcription factor in pancreatic ductal adenocarcinoma. We recently found high levels of AP-1…
View article: Supplementary figure from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism
Supplementary figure from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism Open
Supplemental Figure 1
View article: Supplementary Methods, Figures 1-7 from Nucleotide Excision Repair Factor XPC Enhances DNA Damage–Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2
Supplementary Methods, Figures 1-7 from Nucleotide Excision Repair Factor XPC Enhances DNA Damage–Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2 Open
PDF file - 411K
View article: Supplementary Methods, Figures 1-7 from Nucleotide Excision Repair Factor XPC Enhances DNA Damage–Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2
Supplementary Methods, Figures 1-7 from Nucleotide Excision Repair Factor XPC Enhances DNA Damage–Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2 Open
PDF file - 411K
View article: Data from Nucleotide Excision Repair Factor XPC Enhances DNA Damage–Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2
Data from Nucleotide Excision Repair Factor XPC Enhances DNA Damage–Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2 Open
XPC protein is a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency confers a predisposition to cancer. In this study, we show that XPC has a function that is independent of its canonical func…
View article: Data from Nucleotide Excision Repair Factor XPC Enhances DNA Damage–Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2
Data from Nucleotide Excision Repair Factor XPC Enhances DNA Damage–Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2 Open
XPC protein is a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency confers a predisposition to cancer. In this study, we show that XPC has a function that is independent of its canonical func…
View article: Additional file 1 of BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes
Additional file 1 of BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes Open
Additional file 1.
View article: Epithelial protein lost in neoplasm (EPLIN)-β is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration
Epithelial protein lost in neoplasm (EPLIN)-β is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration Open
Polyamines promote cellular proliferation, and their levels are controlled by ornithine decarboxylase antizyme 1 (Az 1 ), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limitin…
View article: Editorial: Multidisciplinary Approaches in Exploring Cancer Heterogeneity, TME and Therapy Resistance: Perspectives for Systems Medicine
Editorial: Multidisciplinary Approaches in Exploring Cancer Heterogeneity, TME and Therapy Resistance: Perspectives for Systems Medicine Open
EDITORIAL article Front. Cell Dev. Biol., 03 February 2022Sec. Molecular and Cellular Pathology Volume 10 - 2022 | https://doi.org/10.3389/fcell.2022.842596
View article: Impact of COVID-19 pandemic on a developing STEMI care system from a low-middle income country- a prospective observational study
Impact of COVID-19 pandemic on a developing STEMI care system from a low-middle income country- a prospective observational study Open
Background COVID-19 pandemic has produced a great impact in the STEMI (ST Elevation Myocardial Infarction) care systems across the world. Patient hesitancy to seek medical attention for suspected STEMI, necessity of the health care systems…
View article: Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine Open
(Cell Reports 22, 299–312; January 2, 2018) In the originally published version of this article, the authors inadvertently duplicated the immuno-staining images in Figure S3C for the OVCAR3 cell line, stained with the α-R248Q antibody clon…
View article: Echocardiographic assessment of left ventricular mass index and function in hypertensive patients with preserved ejection fraction
Echocardiographic assessment of left ventricular mass index and function in hypertensive patients with preserved ejection fraction Open
Background: The aim of the present study is to detect left ventricular (LV) mass and to find out sub clinical LV diastolic dysfunction in hypertensive patients with preserved LV ejection fraction (EF) using echocardiographic parameters.Met…
View article: Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment
Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment Open
Extracellular vesicles (EVs) shed by cancer cells play a major role in mediating the transfer of molecular information by reprogramming the tumor microenvironment (TME). TP53 (encoding the p53 protein) is the most mutated gene across many …