Kanako Deguchi
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View article: Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia in Chrebp Knockout Mice
Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia in Chrebp Knockout Mice Open
Type 1 diabetes mellitus is a major risk factor for both sarcopenia and osteoporosis, primarily due to the body’s inability to utilize glucose as a result of insulin deficiency. Impairments in insulin and glucose signaling can accelerate t…
View article: Gut Microbiota α- and β-Diversity, but Not Dietary Patterns, Differ Between Underweight and Normal-Weight Japanese Women Aged 20–39 Years
Gut Microbiota α- and β-Diversity, but Not Dietary Patterns, Differ Between Underweight and Normal-Weight Japanese Women Aged 20–39 Years Open
Background and Aim: Underweight young adult women are vulnerable to health risks such as menstrual disorders and vitamin deficiencies. Because few seek medical care for low body weight, the underlying causes remain unclear. This study aime…
View article: High Reproducibility and Agreement of Meal Duration, Number of Chews, and Chewing Tempo Measured with a Standardized Test Meal
High Reproducibility and Agreement of Meal Duration, Number of Chews, and Chewing Tempo Measured with a Standardized Test Meal Open
Background/Aim: To date, there have been no data regarding the reproducibility or agreement of meal duration when a test meal is eaten. To confirm the reproducibility and agreement of the meal duration, number of chews, chewing tempo, and …
View article: The Alpha and Beta Diversities of Dietary Patterns Differed by Age and Sex in Young and Middle-Aged Japanese Participants
The Alpha and Beta Diversities of Dietary Patterns Differed by Age and Sex in Young and Middle-Aged Japanese Participants Open
Background/Objectives: Dietary patterns vary with age and sex. The aim of this study was to clarify the differences in dietary patterns among young and middle-aged Japanese individuals by age group and sex via statistical methods such as a…
View article: Skeletal Muscle Mass Index and Body Fat Percentage Reflect Different Nutritional Markers Independent of BMI in Underweight Women
Skeletal Muscle Mass Index and Body Fat Percentage Reflect Different Nutritional Markers Independent of BMI in Underweight Women Open
Background/Aim: Skeletal muscle mass index (SMI) and body fat percentage (BF%) are components of body mass index (BMI) but are considered to play independent roles. We aimed to clarify whether SMI and BF% are associated with nutritional ma…
View article: The Meal Type Rather than the Meal Sequence Affects the Meal Duration, Number of Chews, and Chewing Tempo
The Meal Type Rather than the Meal Sequence Affects the Meal Duration, Number of Chews, and Chewing Tempo Open
Background/Aim: Obese individuals are often said to eat fast. Given that obese individuals are often reported to consume fast food more frequently, we hypothesized that fast food can be eaten more quickly. This study aimed to examine the e…
View article: Greater Numbers of Chews and Bites and Slow External Rhythmic Stimulation Prolong Meal Duration in Healthy Subjects
Greater Numbers of Chews and Bites and Slow External Rhythmic Stimulation Prolong Meal Duration in Healthy Subjects Open
Background/Aim: Slow eating is recommended for obese individuals. We aimed to determine the associations between meal duration and various factors (sex, numbers of chews and bites, eating tempo (including forced rhythm with a metronome) an…
View article: Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression
Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression Open
Glucose and insulin positively regulate glycolysis and lipogenesis through the activation of carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein 1c (SREBP1c), but their respective roles in t…
View article: Chrebp Deletion and Mild Protein Restriction Additively Decrease Muscle and Bone Mass and Function
Chrebp Deletion and Mild Protein Restriction Additively Decrease Muscle and Bone Mass and Function Open
Background/Objectives: Carbohydrate and protein restriction are associated with sarcopenia and osteopenia, but the underlying mechanisms remain unclear. We aimed to determine whether mild protein restriction affects muscle and bone functio…
View article: Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups
Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups Open
Background/Objectives: The aim of this study is to investigate the association between physical and chemical digestion and nutrition markers (serum albumin (ALB), prealbumin (PAB), and vitamin B12 (B12) levels). Methods: During a detailed …
View article: Associations of Acetic Acid Intake with Protein and Vitamin Intake Estimated via a Food Recording Application
Associations of Acetic Acid Intake with Protein and Vitamin Intake Estimated via a Food Recording Application Open
A conventional questionnaire-based assessment of acetic acid intake is based on the intake of seasonings such as mayonnaise, which could thereby lead to an underestimation. We here determine the relationships of acetic acid intake with nut…
View article: Sex and Age Differences in the Effects of Food Frequency on Metabolic Parameters in Japanese Adults
Sex and Age Differences in the Effects of Food Frequency on Metabolic Parameters in Japanese Adults Open
Owing to differences in dietary preferences between men and women, the associations between dietary intake frequency and metabolic parameters may differ between the sexes. A retrospective observational study of the checkup findings of 3147…
View article: A Study on the Compatibility of a Food-Recording Application with Questionnaire-Based Methods in Healthy Japanese Individuals
A Study on the Compatibility of a Food-Recording Application with Questionnaire-Based Methods in Healthy Japanese Individuals Open
In Japan, nutritional guidance based on food-recording apps and food frequency questionnaires (FFQs) is becoming popular. However, it is not always recognized that different dietary assessment methods have different nutritional values. Her…
View article: Differing Effects of Body Size on Circulating Lipid Concentrations and Hemoglobin A1c Levels in Young and Middle-Aged Japanese Women
Differing Effects of Body Size on Circulating Lipid Concentrations and Hemoglobin A1c Levels in Young and Middle-Aged Japanese Women Open
The condition of being underweight is a social problem in Japan among women. However, there is a lack of evidence for dietary guidance for underweight women because there has been no comparison of lipids or HbA1c among underweight, normal …
View article: Editorial: Diabetic renal tubulointerstitial disease
Editorial: Diabetic renal tubulointerstitial disease Open
However, not all papers gathered on this topic cover renal tubular interstitial injury. Some 61 reported that the genotype of albuminuria in DKD appears to be different from that of eGFR. The 62 proteinuria phenotype seems to cluster with …
View article: Phosphorus content of processed meat products and the changes induced by cooking
Phosphorus content of processed meat products and the changes induced by cooking Open
食肉製品のリン含有量を明らかにすることを目的とし，ウインナーソーセージ（以下，ウインナー）14種類，その他食肉製品10種類のリン含有量をバナドモリブデン酸吸光光度法で測定した．また，ウインナーに4種の調理を行い，リン含有量の変化をみた．ウインナー14種類のリン含有量は118.3～344.0 mg，リン/たんぱく質比は7.4～32.8 mg/gであった．その他食肉製品のリン含有量は84.9～356.4 mg，リン/たんぱく質比は6.5～21.6 mg/gであり，リン酸塩とpH…
View article: Protein-energy wasting and daily nutritional intake in Japanese chronic hemodialysis patients
Protein-energy wasting and daily nutritional intake in Japanese chronic hemodialysis patients Open
維持血液透析患者のprotein-energy wasting (PEW) の実態とPEWとの関連因子を検討した. 透析導入後6か月以上409例の合併症, 身体計測値, 血液検査, 食事摂取量を調査. 国際腎疾患栄養代謝学会による区分に従いPEWを判定し, Logistic回帰分析により関連因子を求めた. 年齢64±11歳, 透析歴8 (3～14) 年, 高血圧合併74.3%, BMI 21.1±3.4kg/m2, 血清Alb 3.7±0.3g/dL, エネルギー30±6k…