Kangcheng Hou
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View article: Common and rare variant genetic contributions in African Americans with autism
Common and rare variant genetic contributions in African Americans with autism Open
The absence of non-European cohorts in genetic studies of neurodevelopmental and neuropsychiatric disorders severely limits the understanding of their full genetic architecture and undermines implementation of precision medicine. Here, we …
View article: Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations
Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations Open
SUMMARY: Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major ba…
View article: Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns
Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns Open
Background Admixed populations offer valuable insight into the genetic architecture of complex traits. Many studies have proposed methods for genome-wide association study (GWAS) in admixed populations and various simulation studies have e…
View article: Pleiotropic heritability quantifies the shared genetic variance of common diseases
Pleiotropic heritability quantifies the shared genetic variance of common diseases Open
Common diseases are highly pleiotropic, but the overall contribution of pleiotropy to a target disease’s architecture is unknown, as most studies focus on genetic correlations with each auxiliary disease in turn. Here we propose a new meth…
View article: Quantitative trait loci mapping of gene expression and chromatin accessibility in primary fibroblast reveals shared allelic effects between Latin American and European ancestries
Quantitative trait loci mapping of gene expression and chromatin accessibility in primary fibroblast reveals shared allelic effects between Latin American and European ancestries Open
Quantitative Trait Locus (QTL) analysis of molecular data has identified genetic variants associated with traits such as gene expression, and colocalization of these functional QTL with GWAS risk loci has offered insights into the genetic …
View article: Additional impact of genetic ancestry over race/ethnicity to prevalence of KRAS mutations and allele-specific subtypes in non-small cell lung cancer
Additional impact of genetic ancestry over race/ethnicity to prevalence of KRAS mutations and allele-specific subtypes in non-small cell lung cancer Open
View article: Temporally distinct 3D multi-omic dynamics in the developing human brain
Temporally distinct 3D multi-omic dynamics in the developing human brain Open
The human hippocampus and prefrontal cortex play critical roles in learning and cognition 1,2 , yet the dynamic molecular characteristics of their development remain enigmatic. Here we investigated the epigenomic and three-dimensional chro…
View article: All of Us diversity and scale improve polygenic prediction contextually with greatest improvements for under-represented populations
All of Us diversity and scale improve polygenic prediction contextually with greatest improvements for under-represented populations Open
Recent studies have demonstrated that polygenic risk scores (PRS) trained on multi-ancestry data can improve prediction accuracy in groups historically underrepresented in genomic studies, but the availability of linked health and genetic …
View article: Calibrated prediction intervals for polygenic scores across diverse contexts
Calibrated prediction intervals for polygenic scores across diverse contexts Open
View article: Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations
Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations Open
Summary Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major bar…
View article: Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders
Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders Open
View article: Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns
Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns Open
Background: Admixed populations offer valuable insight into the genetic architecture of complex traits. Many studies have proposed methods for genome-wide association study (GWAS) in admixed populations and various simulation studies have …
View article: Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations
Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations Open
Summary Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major bar…
View article: Calibrated prediction intervals for polygenic scores across diverse contexts
Calibrated prediction intervals for polygenic scores across diverse contexts Open
Polygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide range of fields from agriculture to personalized medicine. We analyze data from two large biobanks in the US (All of Us) and the UK (UK Biobank) to …
View article: Calibrated prediction intervals for polygenic scores across diverse contexts
Calibrated prediction intervals for polygenic scores across diverse contexts Open
Polygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide range of fields from agriculture to personalized medicine. We analyze data from two large biobanks in the US (All of Us) and the UK (UK Biobank) to …
View article: Genotype error due to low-coverage sequencing induces uncertainty in polygenic scoring
Genotype error due to low-coverage sequencing induces uncertainty in polygenic scoring Open
View article: Cell type deconvolution of bulk blood RNA-Seq to reveal biological insights of neuropsychiatric disorders
Cell type deconvolution of bulk blood RNA-Seq to reveal biological insights of neuropsychiatric disorders Open
Genome-wide association studies (GWAS) have uncovered susceptibility loci associated with psychiatric disorders like bipolar disorder (BP) and schizophrenia (SCZ). However, most of these loci are in non-coding regions of the genome with un…
View article: Impact of cross-ancestry genetic architecture on GWASs in admixed populations
Impact of cross-ancestry genetic architecture on GWASs in admixed populations Open
View article: Polygenic scoring accuracy varies across the genetic ancestry continuum
Polygenic scoring accuracy varies across the genetic ancestry continuum Open
View article: Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms
Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms Open
RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders, yet the role of cell-type-specific splicing or transcript-isoform diversity during human brain development has not been systematically invest…
View article: Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals Open
View article: Impact of cross-ancestry genetic architecture on GWAS in admixed populations
Impact of cross-ancestry genetic architecture on GWAS in admixed populations Open
Genome-wide association studies (GWAS) have identified thousands of variants for disease risk. These studies have predominantly been conducted in individuals of European ancestries, which raises questions about their transferability to ind…
View article: Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus
Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus Open
The human frontal cortex and hippocampus play critical roles in learning and cognition. We investigated the epigenomic and 3D chromatin conformational reorganization during the development of the frontal cortex and hippocampus, using more …
View article: Polygenic scoring accuracy varies across the genetic ancestry continuum in all human populations
Polygenic scoring accuracy varies across the genetic ancestry continuum in all human populations Open
Polygenic scores (PGS) have limited portability across different groupings of individuals (e.g., by genetic ancestries and/or social determinants of health), preventing their equitable use. PGS portability has typically been assessed using…
View article: Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data Open
View article: Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals
Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals Open
Individuals of admixed ancestries (e.g., African Americans) inherit a mosaic of ancestry segments (local ancestry) originating from multiple continental ancestral populations. Their genomic diversity offers the unique opportunity of invest…
View article: Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals
Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals Open
Individuals of admixed ancestries (e.g., African Americans) inherit a mosaic of ancestry segments (local ancestry) originating from multiple continental ancestral populations. Their genomic diversity offers the unique opportunity of invest…
View article: Powerful eQTL mapping through low-coverage RNA sequencing
Powerful eQTL mapping through low-coverage RNA sequencing Open
View article: Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes
Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes Open
View article: A multi-dimensional integrative scoring framework for predicting functional variants in the human genome
A multi-dimensional integrative scoring framework for predicting functional variants in the human genome Open