Kai Ding
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View article: Genos: A Human-Centric Genomic Foundation Model
Genos: A Human-Centric Genomic Foundation Model Open
The rapid expansion of human genomic data demands foundation models that manage ultra-long sequences and capture population diversity, limitations common in existing models which lack human-specific representation and clinical inference ef…
View article: PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis
PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis Open
Background Despite a series of attempts during the last decades, the prognosis for esophageal squamous cell carcinoma (ESCC) remains poor. Although clinical immunotherapy trials have shown encouraging results, their benefits are limited. T…
View article: IonoGAN: An Enhanced Model for Forecasting Quiet and Disturbed Ionospheric Features From Predicted Ionograms
IonoGAN: An Enhanced Model for Forecasting Quiet and Disturbed Ionospheric Features From Predicted Ionograms Open
Ionograms are radar echo graphs that depict vertical ionospheric density profiles, structures, fluctuations, and irregularities, with the F region represented by F‐trace and Spread‐F features in the graphs. In this paper, IonoGAN, an enhan…
View article: Geochemical Ecological Economic Triadic Harmonization: Sustainable Pathways for Earth System
Geochemical Ecological Economic Triadic Harmonization: Sustainable Pathways for Earth System Open
This study presents a framework for achieving global ecological civilization through the principle of ‘Geochemical-ecological-economic triadic harmonization.’ Facing escalating environmental challenges, rigorous implementation of this prin…
View article: T-lymphocytes suppression by CD14+ monocytes with high expression of ULK2 in patients with multiple myeloma
T-lymphocytes suppression by CD14+ monocytes with high expression of ULK2 in patients with multiple myeloma Open
Background: Multiple myeloma (MM), a plasma cell malignancy, is incurable and highly prone to relapse. Immunosuppressive cells in the bone marrow environment inhibit endogenous T-lymphocytes activity and reduce the efficacy immunotherapies…
View article: Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway Open
Our study found that elevated CD200 expression on monocytes in patients with MDS correlates with poor prognosis, suggesting CD200 as a potential prognostic marker. Blocking CD200 enhances NK cell activation and cytotoxicity, indicating tha…
View article: Transforming Agriculture: Empirical Insights into How the Digital Economy Elevates Agricultural Productivity in China
Transforming Agriculture: Empirical Insights into How the Digital Economy Elevates Agricultural Productivity in China Open
The United Nations Sustainable Development Goals (SDGs) emphasize enhancing agricultural productivity sustainably and strengthening the resilience of agricultural systems amidst rising economic uncertainties, escalating climate change risk…
View article: Chemo-Enzymatic Strategy for the Efficient Synthesis of Steroidal Drugs with 10α-Methyl Group and a Side Chain at C17-Position from Biorenewable Phytosterols
Chemo-Enzymatic Strategy for the Efficient Synthesis of Steroidal Drugs with 10α-Methyl Group and a Side Chain at C17-Position from Biorenewable Phytosterols Open
Steroidal pharmaceuticals with a 10α-methyl group or without the methyl group at C10-position are important medicines, but their synthesis is quite challenging, due to that the natural steroidal starting materials usually have a 10β-methyl…
View article: Prediction of Ionograms With/Without Spread‐F at Hainan by a Combined Spatio‐Temporal Neural Network
Prediction of Ionograms With/Without Spread‐F at Hainan by a Combined Spatio‐Temporal Neural Network Open
An intelligent high‐definition and short‐term prediction of ionograms with/without Spread‐F for the observation at Hainan (19.5°N, 109.1°E, magnetic 11°N) is presented in this paper, which comprises a spatio‐temporal ConvGRU network and a …
View article: Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces
Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces Open
Animal feces from livestock farming can be a major source of antibiotic resistance to the environment, but a clear gap exists on how the resistance reservoir in feces alters as farming activities intensify. Here, we sampled feces from eigh…
View article: A Bioaugmentation Strategy for Promoting the Humification Process during Composting by Microbial Inoculants: A Review
A Bioaugmentation Strategy for Promoting the Humification Process during Composting by Microbial Inoculants: A Review Open
Stimulating compost humification is an important way for carbon sequestration and that in itself is significant, especial under the context of carbon neutrality. However, a longer humification cycle occurs in the traditional composting. Mi…
View article: Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces
Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces Open
The uploaded datasets contains two supplementary tables of experimental data described in the paper. Animal feces from livestock farming can be a major source of antibiotic resistance to the environment, but a clear gap exists on how the r…
View article: The value of serum IL-4 to predict the survival of MDS patients
The value of serum IL-4 to predict the survival of MDS patients Open
Background Immune indicators are routinely used for the detection of myelodysplastic syndrome (MDS), but these are not utilized as a reference indicator to assess prognosis in MDS-related prognostic evaluation systems, such as the World He…
View article: Bacterial communities are more sensitive to ocean acidification than fungal communities in estuarine sediments
Bacterial communities are more sensitive to ocean acidification than fungal communities in estuarine sediments Open
Ocean acidification (OA) in estuaries is becoming a global concern, and may affect microbial characteristics in estuarine sediments. Bacterial communities in response to acidification in this habitat have been well discussed; however, know…
View article: Long Non-Coding RNA FAM157C Contributed to Clonal Proliferation in Paroxysmal Nocturnal Hemoglobinuria
Long Non-Coding RNA FAM157C Contributed to Clonal Proliferation in Paroxysmal Nocturnal Hemoglobinuria Open
Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disease of hematopoietic stem cells. However, the mechanism of proliferative advantage of PNH clone is unclear. Long noncoding RNAs (LncRNAs) have a wide range of biolo…
View article: Effects of Chinese fir plantations with different densities on understory vegetation and soil microbial community structure
Effects of Chinese fir plantations with different densities on understory vegetation and soil microbial community structure Open
浙江农林大学省部共建亚热带森林培育国家重点实验室, 杭州 311300; 2 浙江省开化县林场, 浙江开化 324300 摘 要 为揭示土壤养分和细菌群落对林下植被调控的响应机制, 调查了浙江开化3种林分密度(高密度(KH)、中密度(KM)
View article: States, Trends, and Future of Aquaponics Research
States, Trends, and Future of Aquaponics Research Open
As an environmentally-friendly aquaculture and planting system, aquaponics has attracted attention in various fields, such as fisheries, agriculture, and ecology. The existing review qualitatively described the development and challenges o…
View article: Lower expression of the RASSF10 gene induces myeloma cell proliferation due to hypermethylation of the gene promoter in multiple myeloma
Lower expression of the RASSF10 gene induces myeloma cell proliferation due to hypermethylation of the gene promoter in multiple myeloma Open
Background: Multiple myeloma (MM) is an incurable malignant neoplasm of plasma cells, in which genetic defects, epigenetic aberrations and bone marrow microenvironment are involved in the pathogenesis. RASSF10 acts as a tumor suppressor ge…
View article: Lower expression of the RASSF10 gene induces myeloma cell proliferation due to hypermethylation of the gene promoter in multiple myeloma
Lower expression of the RASSF10 gene induces myeloma cell proliferation due to hypermethylation of the gene promoter in multiple myeloma Open
Background Multiple myeloma (MM) is an incurable malignant neoplasm of plasma cells, in which genetic defects, epigenetic aberrations and bone marrow microenvironment are involved in the pathogenesis. RASSF10 acts as a tumor suppressor gen…