Kangling Zhang
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View article: Integrated molecular and microenvironmental drivers of drug resistance in gastrointestinal cancers: mechanisms, immunotherapy challenges, and precision strategies
Integrated molecular and microenvironmental drivers of drug resistance in gastrointestinal cancers: mechanisms, immunotherapy challenges, and precision strategies Open
Resistance to chemotherapy, targeted agents, and particularly immunotherapy remains the principal challenge in the management of gastrointestinal malignancies. This review aims to comprehensively delineate the molecular and microenvironmen…
View article: Temozolomide-Derived AIC Is Incorporated into Purine Synthesis in Glioblastoma
Temozolomide-Derived AIC Is Incorporated into Purine Synthesis in Glioblastoma Open
Glioblastoma (GBM) is a lethal brain tumor with limited therapeutic options. Temozolomide (TMZ), a standard-of-care chemotherapeutic agent, exerts its cytotoxicity by alkylating DNA, which triggers a DNA damage response and depletes ATP an…
View article: Crosstalk between metabolism and epigenetics during macrophage polarization
Crosstalk between metabolism and epigenetics during macrophage polarization Open
Macrophage polarization is a dynamic process driven by a complex interplay of cytokine signaling, metabolism, and epigenetic modifications mediated by pathogens. Upon encountering specific environmental cues, monocytes differentiate into m…
View article: Maternal exposure to bisphenol A has transgenerational effects on the development of experimental asthma through bromodomain-containing protein 4–zinc finger DHHC-type containing 1–stimulators of interferon genes axis
Maternal exposure to bisphenol A has transgenerational effects on the development of experimental asthma through bromodomain-containing protein 4–zinc finger DHHC-type containing 1–stimulators of interferon genes axis Open
Perinatal exposures to the environmental estrogen bisphenol A (BPA) are associated with increased asthma prevalence. We tested the hypothesis that perinatal BPA exposure transgenerationally enhances allergic asthma development through the …
View article: Hypoxia Rewires Histone Methylation Via Enzyme Reprogramming Despite Disruption of One-Carbon Metabolism
Hypoxia Rewires Histone Methylation Via Enzyme Reprogramming Despite Disruption of One-Carbon Metabolism Open
View article: Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and<i>Mycobacterium tuberculosis</i>in macrophages and humanized mice
Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and<i>Mycobacterium tuberculosis</i>in macrophages and humanized mice Open
Coinfections with Mycobacterium tuberculosis (Mtb) and HIV-1 present a critical health challenge and require treatment for survival. We found that human M1 macrophages inhibit Mtb growth, while M2 macrophages, characterized by elevated Sir…
View article: New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis
New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis Open
Arginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conver…
View article: Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis
Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis Open
Macrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism Mycobacterium tuberculosis (MTB) infects and persists in macrophages. Macrophage…
View article: The Oxidative Stress-Induced Hypothetical Protein PG_0686 in Porphyromonas gingivalis W83 Is a Novel Diguanylate Cyclase
The Oxidative Stress-Induced Hypothetical Protein PG_0686 in Porphyromonas gingivalis W83 Is a Novel Diguanylate Cyclase Open
Porphyromonas gingivalis is an important etiological agent in periodontitis and other systemic diseases. There is still a gap in our understanding of the mechanisms that P. gingivalis uses to survive the inflammatory microenvironment of th…
View article: Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing
Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing Open
Recently, we constructed a hybrid thymine DNA glycosylase (hyTDG) by linking a 29-amino acid sequence from the human thymine DNA glycosylase with the catalytic domain of DNA mismatch glycosylase (MIG) from M. thermoautotrophicum, in…
View article: Abstract 2078: Multi-omic analysis of metabolites, proteins, and histone modifications during human macrophage polarization
Abstract 2078: Multi-omic analysis of metabolites, proteins, and histone modifications during human macrophage polarization Open
View article: Multi-OMICs analysis reveals metabolic and epigenetic changes associated with macrophage polarization
Multi-OMICs analysis reveals metabolic and epigenetic changes associated with macrophage polarization Open
Macrophages (MФ) are an essential immune cell for defense and repair that travel to different tissues and adapt based on local stimuli. A critical factor that may govern their polarization is the crosstalk between metabolism and epigenetic…
View article: Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis
Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis Open
View article: Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase
Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase Open
The hydrolytic deamination of cytosine and 5-methylcytosine drives many of the transition mutations observed in human cancer. The deamination-induced mutagenic intermediates include either uracil or thymine adducts mispaired with guanine. …
View article: Decoding Cinnabarinic Acid–Specific Stanniocalcin 2 Induction by Aryl Hydrocarbon Receptor
Decoding Cinnabarinic Acid–Specific Stanniocalcin 2 Induction by Aryl Hydrocarbon Receptor Open
View article: Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods
Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods Open
View article: A simple noninvasive model to predict significant fibrosis in children with chronic hepatitis B
A simple noninvasive model to predict significant fibrosis in children with chronic hepatitis B Open
To develop a noninvasive model to predict significant fibrosis in children with chronic hepatitis B (CHB). A total of 116 CHB pediatric patients who underwent liver biopsy were included in the study. Liver histology, which is the gold stan…
View article: A Simple Noninvasive Model to Predict Significant Fibrosis in Children with Chronic Hepatitis B
A Simple Noninvasive Model to Predict Significant Fibrosis in Children with Chronic Hepatitis B Open
Background: To develope a noninvasive model for significant fibrosis in children with chronic hepatitis B (CHB). Methods: A total 116 CHB pediatric patientswere who had undergone liver biopsy were included in the study. The gold standard o…
View article: A Simple Noninvasive Model to Predict Significant Fibrosis in Children With Chronic Hepatitis B
A Simple Noninvasive Model to Predict Significant Fibrosis in Children With Chronic Hepatitis B Open
Objectives: to develope a noninvasive model for significant fibrosis in children with chronic hepatitis B (CHB). Methods: A total 116 CHB pediatric patients who had undergone liver biopsy were included in the study. Blood routine examinati…
View article: Human M1 Macrophages Express Unique Innate Immune Response Genes After Mycobacterial Infection to Defend Against Tuberculosis
Human M1 Macrophages Express Unique Innate Immune Response Genes After Mycobacterial Infection to Defend Against Tuberculosis Open
View article: Bisphenol A Activates an Innate Viral Immune Response Pathway
Bisphenol A Activates an Innate Viral Immune Response Pathway Open
Bisphenol A (BPA) is a ubiquitous component in the manufacturing of plastic. It is commonly found in food and beverage containers. Because of its broad exposure and evidence that it may act as an estrogen-like molecule, many have studied i…
View article: A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling–Stimulated Thermogenesis
A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling–Stimulated Thermogenesis Open
Carboxylesterase 3 (Ces3) is a hydrolase with a wide range of activities in liver and adipose tissue. In this study, we identified Ces3 as a major lipid droplet surface-targeting protein in adipose tissue upon cold exposure by liquid chrom…
View article: Sex-Specific Proteomic Changes Induced by Genetic Deletion of Fibroblast Growth Factor 14 (FGF14), a Regulator of Neuronal Ion Channels
Sex-Specific Proteomic Changes Induced by Genetic Deletion of Fibroblast Growth Factor 14 (FGF14), a Regulator of Neuronal Ion Channels Open
Fibroblast growth factor 14 (FGF14) is a member of the intracellular FGFs, which is a group of proteins involved in neuronal ion channel regulation and synaptic transmission. We previously demonstrated that male Fgf14−/− mice recapitulate …
View article: Sex-Specific Proteomics Changes Induced by Genetic Deletion of the Fibroblast Growth Factor 14 (FGF14) Regulator of Neuronal Ion Channels
Sex-Specific Proteomics Changes Induced by Genetic Deletion of the Fibroblast Growth Factor 14 (FGF14) Regulator of Neuronal Ion Channels Open
Fibroblast growth factor 14 (FGF14) is a member of the intracellular FGFs, a group of proteins with roles in neuronal ion channel regulation and synaptic transmission. We have previously demonstrated that a male Fgf14-/- mouse model recapi…
View article: Analysis of glucose-derived amino acids involved in one-carbon and cancer metabolism by stable-isotope tracing gas chromatography mass spectrometry
Analysis of glucose-derived amino acids involved in one-carbon and cancer metabolism by stable-isotope tracing gas chromatography mass spectrometry Open
View article: Proteomic changes in traumatic brain injury: experimental approaches
Proteomic changes in traumatic brain injury: experimental approaches Open
Purpose of review The underlying mechanisms responsible for chronic and progressive neurological damage after traumatic brain injury (TBI) are poorly understood, and therefore, current treatment options are limited. Proteomics is an emergi…
View article: Role of Acetyltransferase PG1842 in Gingipain Biogenesis in Porphyromonas gingivalis
Role of Acetyltransferase PG1842 in Gingipain Biogenesis in Porphyromonas gingivalis Open
Gingipain proteases are key virulence factors secreted by Porphyromonas gingivalis that cause periodontal tissue damage and the degradation of the host immune system proteins. Gingipains are translated as an inactive zymogen to restrict in…
View article: Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics
Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics Open
Human metapneumovirus (hMPV) is a leading cause of lower respiratory infection in pediatric populations globally. This study examined proteomic profile changes in A549 cells infected with hMPV and two attenuated mutants with deleted PDZ do…
View article: Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways
Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways Open
View article: Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β
Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β Open
Palmitic acid (PA) and other saturated fatty acids are known to stimulate pro-inflammatory responses in human immune cells via Toll-like receptor 4 (TLR4). However, the molecular mechanism responsible for fatty acid stimulation of TLR4 rem…