Ke Lv
YOU?
Author Swipe
View article: Research progress on sarcopenia in the musculoskeletal system
Research progress on sarcopenia in the musculoskeletal system Open
View article: Obinutuzumab combined with bendamustine for the treatment of hairy cell leukemia variant: a case report and literature review
Obinutuzumab combined with bendamustine for the treatment of hairy cell leukemia variant: a case report and literature review Open
Hairy cell leukemia variant (HCL-v) is a rare and more aggressive subtype of B-cell leukemia. While it shares certain clinical features with classical hairy cell leukemia (HCL-c), HCL-v typically follows a more malignant course and respond…
View article: Image-guided cryoablation for uterine diseases: a systematic review
Image-guided cryoablation for uterine diseases: a systematic review Open
Image-guided cryoablation is a minimally invasive therapy for uterine diseases with statistically and clinically significant effectiveness and a low incidence of major complications.
View article: Ophthalmic changes are associated with visual cortex functional network reorganization after 90-day head-down tilt bed rest
Ophthalmic changes are associated with visual cortex functional network reorganization after 90-day head-down tilt bed rest Open
OBF may be a key risk factor for decreased visual acuity in stimulated microgravity, potentially driving functional network reorganization of the visual cortex by modifying visual function. These insights contribute to a new insight for op…
View article: The Dominant factors and optimization plan of soccer substitutions in Chinese Football Association Super League under the Five-substitution rule
The Dominant factors and optimization plan of soccer substitutions in Chinese Football Association Super League under the Five-substitution rule Open
Substitution strategy is a fundamental component of tactical adjustments in soccer matches. Since the official introduction of the five-substitution rule in 2020, substitute players have faced increased performance demands. This study exam…
View article: Advances in neuroimaging applications of quantitative susceptibility mapping
Advances in neuroimaging applications of quantitative susceptibility mapping Open
This review article delves into the advancements of quantitative susceptibility mapping (QSM) in neuroimaging, highlighting its utility in detecting and quantifying magnetic susceptibility differences in tissues, particularly for paramagne…
View article: The contribution of fires to PM <sub>2.5</sub> and population exposure in Asia Pacific
The contribution of fires to PM <sub>2.5</sub> and population exposure in Asia Pacific Open
Forest and vegetation fires are important sources of air pollution in many regions. Reducing fires may be a significant yet under-recognized option for improving air quality and preventing premature deaths. This study isolates fire-specifi…
View article: Multimodal Imaging-Based Cerebral Blood Flow Prediction Model Development in Simulated Microgravity
Multimodal Imaging-Based Cerebral Blood Flow Prediction Model Development in Simulated Microgravity Open
Background: Abnormal alterations in cerebral blood flow (CBF) have been implicated in cognitive decline and neurodegeneration. Maintaining adequate CBF in astronauts during long-duration microgravity is therefore crucial for the success of…
View article: Normal-Appearing White Matter Injury Mediates the Link between Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis
Normal-Appearing White Matter Injury Mediates the Link between Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis Open
View article: Investigation of GPM6B as a novel therapeutic target in Osteoarthritis
Investigation of GPM6B as a novel therapeutic target in Osteoarthritis Open
View article: Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments
Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments Open
Long-term spaceflight is known to induce disruptions in circadian rhythms, which are driven by a central pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus, but the underlying molecular mechanisms remain unclear. He…
View article: A resting-state EEG dataset for sleep deprivation
A resting-state EEG dataset for sleep deprivation Open
To investigate the impact of sleep deprivation (SD) on mood, alertness, and resting-state electroencephalogram (EEG), we present an eyes-open resting-state EEG dataset. The dataset comprises EEG recordings and cognitive data from 71 partic…
View article: Effects of long-term closed and socially isolating spaceflight analog environment on default mode network connectivity as indicated by fMRI
Effects of long-term closed and socially isolating spaceflight analog environment on default mode network connectivity as indicated by fMRI Open
View article: Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest
Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest Open
View article: Sleep-Monitoring Technology Progress and Its Application in Space
Sleep-Monitoring Technology Progress and Its Application in Space Open
INTRODUCTION: Sleep is an indispensable physiological phenomenon. The complexity of sleep and the time it occupies in human life determine that its quality is positively correlated with human health. Since polysomnography was used in space…
View article: Unmodificated stepless regulation of CRISPR/Cas12a multi-performance
Unmodificated stepless regulation of CRISPR/Cas12a multi-performance Open
As CRISPR technology is promoted to more fine-divided molecular biology applications, its inherent performance finds it increasingly difficult to cope with diverse needs in these different fields, and how to more accurately control the per…
View article: The iron burden of cerebral microbleeds contributes to brain atrophy through the mediating effect of white matter hyperintensity
The iron burden of cerebral microbleeds contributes to brain atrophy through the mediating effect of white matter hyperintensity Open
The goal of this work was to explore the total iron burden of cerebral microbleeds (CMBs) using a semi-automatic quantitative susceptibility mapping and to establish its effect on brain atrophy through the mediating effect of white matter …
View article: Quantitative Ultrasound Image Assessment of the Optic Nerve Subarachnoid Space during 90-day Head-Down Tilt Bed Rest
Quantitative Ultrasound Image Assessment of the Optic Nerve Subarachnoid Space during 90-day Head-Down Tilt Bed Rest Open
More than half of long-duration spaceflight astronauts have experienced ophthalmic abnormalities, collectively termed spaceflight-associated neuro-ocular syndrome (SANS). Microgravity-induced elevation in intracranial pressure(ICP), especi…
View article: Running vs. resistance exercise to counteract deconditioning induced by 90-day head-down bedrest
Running vs. resistance exercise to counteract deconditioning induced by 90-day head-down bedrest Open
Spaceflight is associated with enhanced inactivity, resulting in muscular and cardiovascular deconditioning. Although physical exercise is commonly used as a countermeasure, separate applications of running and resistive exercise modalitie…
View article: The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity
The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity Open
A large number of aerospace practices have confirmed that the aerospace microgravity environment can lead to cognitive function decline. Mitochondria are the most important energy metabolism organelles, and some studies demonstrate that th…
View article: Recent study on the anticancer activity of nobiletin and its metabolites
Recent study on the anticancer activity of nobiletin and its metabolites Open
The exploration of naturally occurring phytochemicals with antitumor potential has been the focus of many studies. Nobiletin, a polymethoxyflavone (PMF) exclusively derived from citrus peels, has been reported as a promising candidate for …
View article: Pterostilbene Ameliorates DSS-Induced Intestinal Epithelial Barrier Loss in Mice via Suppression of the NF-κB-Mediated MLCK-MLC Signaling Pathway
Pterostilbene Ameliorates DSS-Induced Intestinal Epithelial Barrier Loss in Mice via Suppression of the NF-κB-Mediated MLCK-MLC Signaling Pathway Open
The integrity of the intestinal barrier is critical for homeostasis. In this study, we investigated the protective effect of pterostilbene (PTE) on the intestinal epithelium barrier. In vitro results of transepithelial electrical re…
View article: Exosomes derived from circBCRC-3-knockdown mesenchymal stem cells promoted macrophage polarization
Exosomes derived from circBCRC-3-knockdown mesenchymal stem cells promoted macrophage polarization Open
Macrophages play an essential role in the myocardial ischemia-reperfusion injury (MIRI), and the macrophage shifting from M1 to M2 phenotypes might be a potential strategy for the treatment of MIRI. It has been reported that miR-182 plays …
View article: Physiological Acclimatization of the Liver to 180‐Day Isolation and the Mars Solar Day
Physiological Acclimatization of the Liver to 180‐Day Isolation and the Mars Solar Day Open
Physiological changes in humans are evident under environmental conditions similar to those on a Mars mission involving both a space factor (long‐term isolation) and a time factor (the Mars solar day). However, very few studies have invest…
View article: Data for: Hydrogen peroxide modulates clock gene expression via RORa and REV-ERBα/β
Data for: Hydrogen peroxide modulates clock gene expression via RORa and REV-ERBα/β Open
View article: Analysis of miRNA expression profiles in the liver of<i>Clock</i><sup>Δ19</sup>mutant mice
Analysis of miRNA expression profiles in the liver of<i>Clock</i><sup>Δ19</sup>mutant mice Open
The circadian clock controls the physiological functions of many tissues including the liver via an autoregulatory transcriptional−translational feedback loop, of which CLOCK is a core positive component. In addition, many studies have ind…
View article: Personalized Epigenome Remodeling Under Biochemical and Psychological Changes During Long-Term Isolation Environment
Personalized Epigenome Remodeling Under Biochemical and Psychological Changes During Long-Term Isolation Environment Open
It has been reported that several aspects of human health could be disturbed during a long-term isolated environment (for instance, the Mars-500 mission), including psychiatric disorders, circadian disruption, temporal dynamics of gut micr…
View article: Integrated Analysis of DNA Methylation and Biochemical/Metabolic Parameter During the Long-Term Isolation Environment
Integrated Analysis of DNA Methylation and Biochemical/Metabolic Parameter During the Long-Term Isolation Environment Open
Numerous studies have shown that changes in the epigenome are an important cause of human biochemical or metabolic parameter changes. Biochemical/metabolic parameter disorders of the human body are usually closely related to the occurrence…
View article: Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of <i>Clock</i>Δ19 mutant mice
Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of <i>Clock</i>Δ19 mutant mice Open
Circadian locomotor output cycles kaput protein (CLOCK) is a core transcription factor of complex integrated feedback loops in mammalian circadian clock. More genes have been reported to be regulated by CLOCK, however little is known about…
View article: Selective enrichment of CD133+/SOX2+ glioblastoma stem cells via adherent culture
Selective enrichment of CD133+/SOX2+ glioblastoma stem cells via adherent culture Open
Most of the brain tumors are malignant with an extremely poor survival rate. Recent progress in identifying cancer stem cells (CSCs) within the brain tumors is starting to revolutionize our understanding in the imitation and progression of…