Kaoru Fujikawa
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View article: Anatomical reassessment of the rat cortical drill-hole injury model
Anatomical reassessment of the rat cortical drill-hole injury model Open
View article: Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer
Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer Open
View article: Eggshell membrane supplementation stimulates angiogenesis and promotes bone healing in a rat drill-hole injury model
Eggshell membrane supplementation stimulates angiogenesis and promotes bone healing in a rat drill-hole injury model Open
The development of new adjunct therapies to support bone healing remains an important clinical challenge. Eggshell membrane (ESM), a natural biomaterial derived from chicken eggs, has recently attracted attention for its safety, biocompati…
View article: Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer
Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer Open
Bacterial flora is present in various parts of the human body, and recent studies have detected bacterial 16S rRNA genes in the bloodstream. Distinct blood microbiomes have been identified in various diseases, including cancer, and are tho…
View article: Non-contact electrical stimulation via a Vector-potential transformer promotes bone healing in drill-hole injury model
Non-contact electrical stimulation via a Vector-potential transformer promotes bone healing in drill-hole injury model Open
View article: Intake of eggshell membrane enhances bone mass and suppresses bone marrow adiposity in normal growing rats
Intake of eggshell membrane enhances bone mass and suppresses bone marrow adiposity in normal growing rats Open
Eggshell membrane intake is considered to have beneficial effects on bone health; however, relevant evidence remains scant. Therefore, we aimed to explore the direct effects of eggshell membrane intake on osteogenic function in normal grow…
View article: Intake of Eggshell Membrane Enhances Bone Mass and Suppresses Bone Marrow Adiposity in Normal Growing Rats
Intake of Eggshell Membrane Enhances Bone Mass and Suppresses Bone Marrow Adiposity in Normal Growing Rats Open
View article: Effects of Vector Potential Irradiation on Rat Femur Histological Analysis
Effects of Vector Potential Irradiation on Rat Femur Histological Analysis Open
View article: Histological Analysis of the Effect of a Vector Potential Generator on the Femur of a Hindlimb-Suspended Rat
Histological Analysis of the Effect of a Vector Potential Generator on the Femur of a Hindlimb-Suspended Rat Open
Disuse osteoporosis occurs due to rest and reduced mechanical stimulation. Under these conditions, bone resorption exceeds bone formation, leading to a decrease in bone density. Vector potential (VP) generators have been developed, and the…
View article: Vector potential dual effect of promoting the proliferation of chondrocytes and inhibiting the calcification process in the articular cartilage
Vector potential dual effect of promoting the proliferation of chondrocytes and inhibiting the calcification process in the articular cartilage Open
OA commonly affects the articular cartilage of the tibia, and its calcification worsens its advancement and its prevalence has recently increased. Vector potential (VP) represents a novel physical therapy for treating OA. Since the impact …
View article: Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors
Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors Open
Introduction Regulatory T cells (Tregs) have attracted attention as a novel therapeutic target to augment the clinical efficacy of immunotherapy. We conducted phase Ia and Ib trials to examine the safety and efficacy of the anti-CCR4 antib…
View article: Effect of load reduction on the calcification of rat tibial tuberosity: Focus on calcification factors and chondrocyte mechanosensors
Effect of load reduction on the calcification of rat tibial tuberosity: Focus on calcification factors and chondrocyte mechanosensors Open
The tibial tuberosity has a superficial patellar tendon-embedded portion and a deep uncalcified cartilage portion. Osgood–Schlatter disease occurs because of suppressed calcification of the tibial tuberosity. The tibial tuberosity calcifie…
View article: Author Correction: Eccentric contractions during downhill running induce Osgood‒Schlatter disease in the tibial tuberosity in rats: a focus on histological structures
Author Correction: Eccentric contractions during downhill running induce Osgood‒Schlatter disease in the tibial tuberosity in rats: a focus on histological structures Open
View article: Eccentric contractions during downhill running induce Osgood‒Schlatter disease in the tibial tuberosity in rats: a focus on histological structures
Eccentric contractions during downhill running induce Osgood‒Schlatter disease in the tibial tuberosity in rats: a focus on histological structures Open
View article: Lymph Node Diameter as a Predictor of Lymph Node Metastasis in Patients with Colorectal Neuroendocrine Neoplasms
Lymph Node Diameter as a Predictor of Lymph Node Metastasis in Patients with Colorectal Neuroendocrine Neoplasms Open
Surgical resection with lymphadenectomy should be considered for patients with LNs of >3 mm in diameter.
View article: A Case of Esophagogastric Junctional Cancer that Underwent Laparoscopic Paraaortic Lymph Node Resection
A Case of Esophagogastric Junctional Cancer that Underwent Laparoscopic Paraaortic Lymph Node Resection Open
肺サルコイドーシスの既往がある40歳女性.食道胃接合部癌,cT3N1と診断された.腹部大動脈周囲リンパ節にPETにてFDG集積を伴う腫大リンパ節を認め,サルコイドーシスまたは接合部癌リンパ節転移が疑われた.リンパ節転移評価目的で,腹腔鏡下噴門側胃切除 下部食道切除術 D1+郭清 食道残胃吻合に加えて腹腔鏡下#16b1 latサンプリングを行った.手術時間400分,出血量少量,周術期合併症を認めず,術後10日目に退院した.腹部大動脈周囲リンパ節はサルコイドーシスの診断で,最終…
View article: Role of Innate Inflammation in the Regulation of Tissue Remodeling during Tooth Eruption
Role of Innate Inflammation in the Regulation of Tissue Remodeling during Tooth Eruption Open
Tooth eruption is characterized by a coordinated complex cascade of cellular and molecular events that promote tooth movement through the eruptive pathway. During tooth eruption, the stratum intermedium structurally changes to the papillar…
View article: An in situ hybridization study of the <i>Syndecan</i> family in the developing condylar cartilage of fetal mouse mandible
An in situ hybridization study of the <i>Syndecan</i> family in the developing condylar cartilage of fetal mouse mandible Open
Mandibular condylar cartilage is a representative secondary cartilage, differing from primary cartilage in various ways. Syndecan is a cell‐surface heparan sulfate proteoglycan and speculated to be involved in chondrogenesis and osteogenes…
View article: Expression, localization and synthesis of small leucine-rich proteoglycans in developing mouse molar tooth germ
Expression, localization and synthesis of small leucine-rich proteoglycans in developing mouse molar tooth germ Open
The gene expression and protein synthesis of small leucine-rich proteoglycans (SLRPs), including decorin, biglycan, fibromodulin, and lumican, was analyzed in the context of the hypothesis that they are closely related to tooth formation. …
View article: A G1 9-mm Rectal Neuroendocrine Neoplasm with Lymph Node Metastasis
A G1 9-mm Rectal Neuroendocrine Neoplasm with Lymph Node Metastasis Open
10mm未満の直腸神経内分泌腫瘍（NEN）のリンパ節転移率は低率であるが，微小病変でもリンパ節転移を認める例も報告されており治療戦略は確立されていない．今回，リンパ節転移を伴った９mmの直腸神経内分泌腫瘍G1の１例を経験した．症例は70歳男性，大腸内視鏡検査にて直腸Rb部に小指頭大の粘膜下腫瘤を指摘された．腫瘤は頂部に陥凹を伴っており，生検にてNEN G1の診断となった．腹部CT検査にて10mm大のリンパ節腫大を指摘され腹腔鏡下低位前方切除術（D2郭清）を施行した．病理所見…
View article: Histochemical and Ultrastructural Study of Developing Gonial Bone With Reference to Initial Ossification of the Malleus and Reduction of Meckel's Cartilage in Mice
Histochemical and Ultrastructural Study of Developing Gonial Bone With Reference to Initial Ossification of the Malleus and Reduction of Meckel's Cartilage in Mice Open
Development of mouse gonial bone and initial ossification process of malleus were investigated. Before the formation of the gonial bone, the osteogenic area expressing alkaline phosphatase and Runx2 mRNA was widely recognized inferior to M…
View article: An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage
An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage Open
The main purpose of this in situ hybridization study was to investigate mRNA expression of three bone/cartilage matrix components (perlecan, DMP1, and MEPE) in developing primary (tibial) and secondary (condylar) cartilage. Perlecan mRNA e…