Kaoru Inoue
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View article: Detailed hazard assessment of ethylbenzene to establish an indoor air quality guideline in Japan
Detailed hazard assessment of ethylbenzene to establish an indoor air quality guideline in Japan Open
It would be appropriate to adopt 0.0858 ppm (370 µg/m3) as a representative hazard assessment value to provide a basis for revising the IAQ guideline value for EB.
View article: Optimal Energy-Saving Trajectories of an Induction Motor Using Core Loss Resistance Map
Optimal Energy-Saving Trajectories of an Induction Motor Using Core Loss Resistance Map Open
During variable speed operation, the energy loss of an induction motor varies depending on the time waveforms (trajectories) of rotational angular velocity, torque, and rotor flux. Therefore, the optimal trajectories should be derived to m…
View article: Derivation of human health hazard assessment values for tetramethylammonium hydroxide (TMAH) under the Japan Chemical Substances Control Law
Derivation of human health hazard assessment values for tetramethylammonium hydroxide (TMAH) under the Japan Chemical Substances Control Law Open
View article: DUX4 double whammy: The transcription factor that causes a rare muscular dystrophy also kills the precursors of the human nose
DUX4 double whammy: The transcription factor that causes a rare muscular dystrophy also kills the precursors of the human nose Open
SMCHD1 mutations cause congenital arhinia (absent nose) and a muscular dystrophy called FSHD2. In FSHD2, loss of SMCHD1 repressive activity causes expression of double homeobox 4 (DUX4) in muscle tissue, where it is toxic. Studies of arhin…
View article: Cross-sectional Neuromuscular Phenotyping Study of Patients With Arhinia With <i>SMCHD1</i> Variants
Cross-sectional Neuromuscular Phenotyping Study of Patients With Arhinia With <i>SMCHD1</i> Variants Open
In this cross-sectional study, we identified patients with arhinia who meet the full genetic and epigenetic criteria for FSHD2 and display the molecular hallmark of FSHD-DUX4 de-repression and expression in vitro-but who do not mani…
View article: Multimodal regulatory elements within a hormone-specific super enhancer control a heterogeneous transcriptional response
Multimodal regulatory elements within a hormone-specific super enhancer control a heterogeneous transcriptional response Open
View article: Derivation of human health hazard assessment values for toluene under the Japanese Chemical Substances Control Law
Derivation of human health hazard assessment values for toluene under the Japanese Chemical Substances Control Law Open
Toluene had been designated as a priority assessment chemical substance under the Japanese Chemical Substances Control Law (CSCL), and as a result of prioritization, a detailed human health hazard assessment was conducted under Assessment …
View article: Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis Open
Benchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is …
View article: IEEJ Industry Applications Society
IEEJ Industry Applications Society Open
View article: IEEJ Industry Applications Society
IEEJ Industry Applications Society Open
View article: IEEJ Industry Applications Society
IEEJ Industry Applications Society Open
View article: Constructing a developmental and reproductive toxicity database of chemicals (DART NIHS DB) for integrated approaches to testing and assessment
Constructing a developmental and reproductive toxicity database of chemicals (DART NIHS DB) for integrated approaches to testing and assessment Open
Developmental and reproductive toxicity (DART) is an important endpoint, and databases (DBs) are essential for evaluating the risk of untested substances using alternative methods. We have constructed a reliable and transparent DART DB, wh…
View article: Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats
Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats Open
The Japanese government requires risk assessment of chemicals under the Chemical Substances Control Law (CSCL). Toxicity data for polyoxymethylene (paraformaldehyde; CAS No.: 30525-89-4) for human health are insufficient though the chemica…
View article: IEEJ Industry Applications Society
IEEJ Industry Applications Society Open
View article: IEEJ Industry Applications Society
IEEJ Industry Applications Society Open
View article: Elements at the 5′ end of Xist harbor SPEN-independent transcriptional antiterminator activity
Elements at the 5′ end of Xist harbor SPEN-independent transcriptional antiterminator activity Open
The Xist lncRNA requires Repeat A, a conserved RNA element located in its 5′ end, to induce gene silencing during X-chromosome inactivation. Intriguingly, Repeat A is also required for production of Xist. While silencing by Repeat A requir…
View article: Simulation-based assessment of model selection criteria during the application of benchmark dose method to quantal response data
Simulation-based assessment of model selection criteria during the application of benchmark dose method to quantal response data Open
Background To employ the benchmark dose (BMD) method in toxicological risk assessment, it is critical to understand how the BMD lower bound for reference dose calculation is selected following statistical fitting procedures of multiple mat…
View article: IEEJ Industry Applications Society
IEEJ Industry Applications Society Open
View article: Elements at the 5′ end of<i>Xist</i>harbor SPEN-independent transcriptional antiterminator activity
Elements at the 5′ end of<i>Xist</i>harbor SPEN-independent transcriptional antiterminator activity Open
The Xist lncRNA requires Repeat A, a conserved RNA element located in its 5′ end, to induce gene silencing during X-chromosome inactivation. Intriguingly, Repeat A is also required for the production of Xist . While silencing by Repeat A r…
View article: Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose
Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose Open
Context The reproductive axis is controlled by a network of gonadotropin-releasing hormone (GnRH) neurons born in the primitive nose that migrate to the hypothalamus alongside axons of the olfactory system. The observation that congenital …
RETRACTION: A 5′ fragment of Xist can sequester RNA produced from adjacent genes on chromatin Open
View article: Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats
Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats Open
3-Methylpentane, isooctane, and isononane are acyclic branched saturated hydrocarbons with carbon numbers C6, C8, and C9, respectively. To assess human risk, we conducted a combined repeated-dose and reproductive/developmental oral toxicit…
View article: A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1
A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1 Open
View article: RETRACTED: A 5′ fragment of Xist can sequester RNA produced from adjacent genes on chromatin
RETRACTED: A 5′ fragment of Xist can sequester RNA produced from adjacent genes on chromatin Open
Xist requires Repeat-A, a protein-binding module in its first two kilobases (2kb), to repress transcription. We report that when expressed as a standalone transcript in mouse embryonic stem cells (ESCs), the first 2kb of Xist (Xist-2kb) do…
View article: A Statistical Method for Joint Estimation of <i>Cis</i>-eQTLs and Parent-of-Origin Effects Under Family Trio Design
A Statistical Method for Joint Estimation of <i>Cis</i>-eQTLs and Parent-of-Origin Effects Under Family Trio Design Open
RNA sequencing allows one to study allelic imbalance of gene expression, which may be due to genetic factors or genomic imprinting (i.e., higher expression of maternal or paternal allele). It is desirable to model both genetic and parent-o…
View article: Comprehensive toxicity evaluation of cyclopentyl methyl ether (CPME) for establishing a permitted daily exposure level
Comprehensive toxicity evaluation of cyclopentyl methyl ether (CPME) for establishing a permitted daily exposure level Open
Cyclopentyl methyl ether (CPME, CAS No. 5614-37-9) is used as an alternative to other ethereal solvents in pharmaceutical chemical process development. Although brief summaries on the repeated dose toxicity or genotoxicity of CPME are avai…
View article: Functional classification of long non-coding RNAs by k-mer content
Functional classification of long non-coding RNAs by k-mer content Open
View article: Issue Information
Issue Information Open
Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices.It has the common focus of biomaterial…
View article: Morphological and immunohistochemical diversity of endometrial stromal sarcoma in rats
Morphological and immunohistochemical diversity of endometrial stromal sarcoma in rats Open
To clarify the histopathological characteristics of rat endometrial stromal sarcoma (ESS), we morphologically reviewed 12 malignant uterine tumors protruding into the lumen in previous rat carcinogenicity studies. The 12 cases were classif…
View article: In Silico Prediction of Chemical-Induced Hepatocellular Hypertrophy Using Molecular Descriptors
In Silico Prediction of Chemical-Induced Hepatocellular Hypertrophy Using Molecular Descriptors Open
In silico prediction for toxicity of chemicals is required to reduce cost, time, and animal testing. However, predicting hepatocellular hypertrophy, which often affects the derivation of the No-Observed-Adverse-Effect Level in repeated dos…