Kar‐Ming Fung
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View article: Evaluation of radio frequency ablation in human left atrial tissues for atrial fibrillation using optical coherence tomography
Evaluation of radio frequency ablation in human left atrial tissues for atrial fibrillation using optical coherence tomography Open
Despite its widespread adoption, the success of radiofrequency (RF) ablation is often limited by challenges in achieving durable, transmural lesions while avoiding complications such as incomplete ablation or over-ablation. Optical coheren…
View article: Deep Learning for Autonomous Surgical Guidance Using 3‐Dimensional Images From Forward‐Viewing Endoscopic Optical Coherence Tomography
Deep Learning for Autonomous Surgical Guidance Using 3‐Dimensional Images From Forward‐Viewing Endoscopic Optical Coherence Tomography Open
A three‐dimensional convolutional neural network (3D‐CNN) was developed for the analysis of volumetric optical coherence tomography (OCT) images to enhance endoscopic guidance during percutaneous nephrostomy. The model was performance‐benc…
View article: Magnetic Resonance Imaging/Transrectal Ultrasound (MRI/TRUS) Fusion-Guided Prostate Biopsy: A Single-Center Experience
Magnetic Resonance Imaging/Transrectal Ultrasound (MRI/TRUS) Fusion-Guided Prostate Biopsy: A Single-Center Experience Open
MRI/TRUS fusion-guided prostate biopsy is a feasible and safe procedure. Our experience with the procedure, including peri-procedure assessment, fusion technique, and biopsy technique, was described in detail. A combination of systematic a…
View article: A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity
A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity Open
Glioblastoma (GBM) is the most aggressive form of brain cancer, with limited therapeutic options. While microglia contribute to GBM progression, the mechanisms by which they foster a protumorigenic immune environment remain poorly understo…
View article: Malignant Transformation of a Vestibular Schwannoma Without Previous Radiation Exposure: Illustrative Case and Literature Review
Malignant Transformation of a Vestibular Schwannoma Without Previous Radiation Exposure: Illustrative Case and Literature Review Open
Although malignant transformation of benign vestibular schwannoma (VS) preceded by irradiation has been well documented, few studies have demonstrated malignant transformation in the absence of radiation. Here, we present a rare case of th…
View article: Comprehensive Evaluation of Human Donor Liver Viability with Polarization-Sensitive Optical Coherence Tomography
Comprehensive Evaluation of Human Donor Liver Viability with Polarization-Sensitive Optical Coherence Tomography Open
Human liver transplantation is severely constrained by a critical shortage of donor livers, with approximately one quarter of patients on the waiting list dying due to the scarcity of viable organs. Current liver viability assessments, whi…
View article: Octascope: A Lightweight Pre-Trained Model for Optical Coherence Tomography
Octascope: A Lightweight Pre-Trained Model for Optical Coherence Tomography Open
Optical coherence tomography (OCT) imaging enables high resolution visualization of sub-surface tissue microstructures. However, OCT image analysis using deep learning is hampered by limited diverse training data to meet performance requir…
View article: Supplementary Figure S2 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer
Supplementary Figure S2 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer Open
Supplementary Figure S2
View article: Supplementary Figure S2 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer
Supplementary Figure S2 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer Open
Supplementary Figure S2
View article: Supplementary Figure S1 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer
Supplementary Figure S1 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer Open
Supplementary Figure S1
View article: Supplementary Table S1 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer
Supplementary Table S1 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer Open
Supplementary Table 1: CyTOF antibody panel and source
View article: Data from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer
Data from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer Open
Purpose: Granulocyte colony stimulating factor (GCSF) enhances colon cancer development. This study defines the prevalence and effects of increased GCSF signaling in human colon cancers and investigates GCSF inhibition as an immunotherapeu…
View article: Supplementary Figure S1 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer
Supplementary Figure S1 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer Open
Supplementary Figure S1
View article: Supplementary Table S1 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer
Supplementary Table S1 from Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer Open
Supplementary Table 1: CyTOF antibody panel and source
View article: Automatic renal carcinoma biopsy guidance using forward-viewing endoscopic optical coherence tomography and deep learning
Automatic renal carcinoma biopsy guidance using forward-viewing endoscopic optical coherence tomography and deep learning Open
Percutaneous renal biopsy is commonly used for kidney cancer diagnosis. However, the biopsy procedure remains challenging in sampling accuracy. Here we introduce a forward-viewing optical coherence tomography probe for differentiating tumo…
View article: Utilizing a Pathomics Biomarker to Predict the Effectiveness of Bevacizumab in Ovarian Cancer Treatment
Utilizing a Pathomics Biomarker to Predict the Effectiveness of Bevacizumab in Ovarian Cancer Treatment Open
The purpose of this investigation is to develop and initially assess a quantitative image analysis scheme that utilizes histopathological images to predict the treatment effectiveness of bevacizumab therapy in ovarian cancer patients. As a…
View article: The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia
The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia Open
With limited treatment options, cachexia remains a major challenge for patients with cancer. Characterizing the interplay between tumor cells and the immune microenvironment may help identify potential therapeutic targets for cancer cachex…
View article: End-to-end deep learning method for predicting hormonal treatment response in women with atypical endometrial hyperplasia or endometrial cancer
End-to-end deep learning method for predicting hormonal treatment response in women with atypical endometrial hyperplasia or endometrial cancer Open
These findings demonstrate the potential of using mixed supervised machine learning models on WSIs for predicting the response to hormonal treatment in AEH/EC patients.
View article: Contribution of Circulating Mfge8 to Human T2DM and Cardiovascular Disease
Contribution of Circulating Mfge8 to Human T2DM and Cardiovascular Disease Open
MFGE8 is a major exosome (EV) protein known to mediate inflammation and atherosclerosis in type 2 diabetes mellitus (T2DM) in animal studies. However, its role in the pathophysiology of human T2DM, obesity, and cardiovascular disease has b…
View article: Percutaneous Nephrostomy Guidance by a Convolutional Neural Network Based Endoscopic Optical Coherence Tomography System
Percutaneous Nephrostomy Guidance by a Convolutional Neural Network Based Endoscopic Optical Coherence Tomography System Open
Percutaneous nephrostomy (PCN) is a commonly used procedure for kidney surgeries. However, difficulties persist in precisely locating the PCN needle tip during its insertion into the kidney. Challenges for PCN needle guidance exist in two …
View article: Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay
Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay Open
Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergenc…
View article: Enhancing epidural needle guidance using a polarization‐sensitive optical coherence tomography probe with convolutional neural networks
Enhancing epidural needle guidance using a polarization‐sensitive optical coherence tomography probe with convolutional neural networks Open
Epidural anesthesia helps manage pain during different surgeries. Nonetheless, the precise placement of the epidural needle remains a challenge. In this study, we developed a probe based on polarization‐sensitive optical coherence tomograp…
View article: Decision-Making in Clival Mass Lesions: Risk Factors for Malignant Disease and an Illustrative Case Example
Decision-Making in Clival Mass Lesions: Risk Factors for Malignant Disease and an Illustrative Case Example Open
Introduction Clival tumors are rare and heterogeneous. Although some benign prototypical sellar lesions may present as clival tumors, the likelihood of malignant disease is higher. Here we define a novel algorithm for the workup and manage…
View article: Regenerative Engineering of a Biphasic Patient-Fitted Temporomandibular Joint Condylar Prosthesis
Regenerative Engineering of a Biphasic Patient-Fitted Temporomandibular Joint Condylar Prosthesis Open
Regenerative medicine approaches to restore the mandibular condyle of the temporomandibular joint (TMJ) may fill an unmet patient need. In this study, a method to implant an acellular regenerative TMJ prosthesis was developed for orthotopi…
View article: Data from G-CSF Is a Novel Mediator of T-Cell Suppression and an Immunotherapeutic Target for Women with Colon Cancer
Data from G-CSF Is a Novel Mediator of T-Cell Suppression and an Immunotherapeutic Target for Women with Colon Cancer Open
Purpose:G-CSF enhances colon cancer development. This study defines the prevalence and effects of increased G-CSF signaling in human colon cancers and investigates G-CSF inhibition as an immunotherapeutic strategy against metastatic colon …