Kara Jensen
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View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually cau…
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually cau…
View article: Virus–Host Interactions Between Nonsecretors and Human Norovirus
Virus–Host Interactions Between Nonsecretors and Human Norovirus Open
View article: Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans
Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans Open
View article: Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species
Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species Open
Sarbecovirus (CoV) infections, including Severe Acute Respiratory CoV (SARS-CoV) and SARS-CoV-2, are considerable human threats. Human GWAS studies have recently identified loci associated with variation in SARS-CoV-2 susceptibility. Howev…
View article: Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross mice
Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross mice Open
Summary Variation in immune homeostasis, immune system stability, in organ systems such as the lungs is likely to shape the host response to infection at these exposed tissues. We evaluated immune homeostasis in immune cell populations in …
View article: A Recombinant Attenuated Mycobacterium tuberculosis Vaccine Strain Is Safe in Immunosuppressed Simian Immunodeficiency Virus-Infected Infant Macaques
A Recombinant Attenuated Mycobacterium tuberculosis Vaccine Strain Is Safe in Immunosuppressed Simian Immunodeficiency Virus-Infected Infant Macaques Open
Many resource-poor countries are faced with concurrent epidemics of AIDS and tuberculosis (TB) caused by human immunodeficiency virus (HIV) and Mycobacterium tuberculosis , respectively. Dual infections with HIV and M. tuberculosis are esp…
View article: Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques
Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques Open
Despite significant progress in reducing peripartum mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) with antiretroviral therapy (ART), continued access to ART throughout the breastfeeding period is still a limitin…
View article: A mouse model for MERS coronavirus-induced acute respiratory distress syndrome
A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Open
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that emerged in 2012, causing acute respiratory distress syndrome (ARDS), severe pneumonia-like symptoms, and multi-organ failure, with a case fatality rate of ~36%. …
View article: Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain Open
Zika virus (ZIKV) is a flavivirus with teratogenic effects on fetal brain, but the spectrum of ZIKV-induced brain injury is unknown, particularly when ultrasound imaging is normal. In a pregnant pigtail macaque (Macaca nemestrina) model of…
View article: Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis
Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis Open
Newly emerging viral pathogens pose a constant and unpredictable threat to human and animal health. Coronaviruses (CoVs) have a penchant for sudden emergence, as evidenced by severe acute respiratory syndrome coronavirus (SARS-CoV), Middle…
View article: Virus–Host Interactions Between Nonsecretors and Human Norovirus
Virus–Host Interactions Between Nonsecretors and Human Norovirus Open
These data support development of within-genogroup, cross-reactive antibody and T-cell immunity, key outcomes that may provide the foundation for eliciting broad immune responses after GII.4 vaccination in individuals with limited GII.4 im…
View article: The interplay between immune maturation, age, chronic viral infection and environment
The interplay between immune maturation, age, chronic viral infection and environment Open
Background The worldwide increase in life expectancy has been associated with an increase in age-related morbidities. The underlying mechanisms resulting in immunosenescence are only incompletely understood. Chronic viral infections, in pa…
View article: Characterization of a Novel Mycobacterium Tuberculosis-Simian Immunodeficiency Virus Vaccine to Prevent Oral Pediatric HIV Transmission
Characterization of a Novel Mycobacterium Tuberculosis-Simian Immunodeficiency Virus Vaccine to Prevent Oral Pediatric HIV Transmission Open
Over 3.3 million children are living with HIV, infected primarily by mother-to-child transmission (MTCT). Breast milk exposure of HIV accounts for up to 44% of MTCT events. Despite serious efforts to prevent vertical HIV transmission, infa…
View article: Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis
Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis Open
Newly emerging viral pathogens pose a constant and unpredictable threat to human and animal health. Coronaviruses (CoVs) have a penchant for sudden emergence, as evidenced by severe acute respiratory syndrome coronavirus (SARS-CoV), Middle…
View article: Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis Open
The complement system is a critical part of host defense to many bacterial, viral, and fungal infections. It works alongside pattern recognition receptors to stimulate host defense systems in advance of activation of the adaptive immune re…
View article: A simultaneous oral and intramuscular prime/sublingual boost with a DNA/Modified Vaccinia Ankara viral vector‐based vaccine induces simian immunodeficiency virus‐specific systemic and mucosal immune responses in juvenile rhesus macaques
A simultaneous oral and intramuscular prime/sublingual boost with a DNA/Modified Vaccinia Ankara viral vector‐based vaccine induces simian immunodeficiency virus‐specific systemic and mucosal immune responses in juvenile rhesus macaques Open
Background A pediatric vaccine to prevent breast milk transmission of human immunodeficiency virus (HIV) may generate greater immune responses at viral entry sites if given by an oral route. Methods We compared immune responses induced in …
View article: Early Sites of Virus Replication After Oral SIV<sub>mac251</sub> Infection of Infant Macaques: Implications for Pathogenesis
Early Sites of Virus Replication After Oral SIV<sub>mac251</sub> Infection of Infant Macaques: Implications for Pathogenesis Open
Despite optimization of preventative measures for vertical HIV-1 transmission, daily, roughly 400 infants become HIV infected, most of them through breastfeeding. Viral entry has been presumed to occur in the gastrointestinal tract; howeve…
View article: A mouse model for MERS coronavirus-induced acute respiratory distress syndrome
A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Open
View article: Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine
Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine Open
Our goal is to develop a pediatric combination vaccine to protect the vulnerable infant population against human immunodeficiency virus type 1 (HIV-1) and tuberculosis (TB) infections. The vaccine consists of an auxotroph Mycobacterium tub…
View article: Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques
Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques Open
Despite significant progress in reducing peripartum mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) with antiretroviral therapy (ART), continued access to ART throughout the breastfeeding period is still a limitin…
View article: The interplay between immune maturation, age, chronic viral infection and environment
The interplay between immune maturation, age, chronic viral infection and environment Open
Our data validate rhesus macaques as a relevant animal model to study how chronic viral infections modulate host immunity and impact immunosenescence. Comparative studies in SPF-2 and non-SPF macaques could identify important mechanisms as…