Karan Devasani
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View article: Pyrroloquinoline Quinone inhibits PCSK9, augments LDLR recycling and enhances the effect of atorvastatin
Pyrroloquinoline Quinone inhibits PCSK9, augments LDLR recycling and enhances the effect of atorvastatin Open
High fat diet intake or statin therapy are known to increase the expression of PCSK9, a key factor involved in the lipid metabolism. Inhibition of PCSK9 is a potential novel strategy for treatment of CVD. Aim of the present study is to inv…
View article: Expression and functions of adenylyl cyclases in the CNS
Expression and functions of adenylyl cyclases in the CNS Open
Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In this review, we first introduce …
View article: Melatonin ameliorates neuropathy in diabetic rats by abating mitochondrial dysfunction and metabolic derangements.
Melatonin ameliorates neuropathy in diabetic rats by abating mitochondrial dysfunction and metabolic derangements. Open
Objectives: To investigate the impact of melatonin per se and in combination with gabapentin in a laboratory animal model of experimental diabetes and associated neuropathy in rats. Methods: Rats from all the groups except the vehicle cont…