Katherine J. Sapra
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View article: Physiologically Based Modeling of Cefoxitin, Cefazolin, and Piperacillin Pharmacokinetics in Obese and Lean Rats
Physiologically Based Modeling of Cefoxitin, Cefazolin, and Piperacillin Pharmacokinetics in Obese and Lean Rats Open
The prevalence of obesity is rapidly increasing worldwide, however there is a notable gap in understanding how obesity affects the pharmacokinetics of drugs and how dosing should be adjusted in obese population. The goals of this work were…
View article: Health Care Leaders’ Perspectives on the Maryland All-Payer Model
Health Care Leaders’ Perspectives on the Maryland All-Payer Model Open
The implementation of hospital global budgets in the state of Maryland offers generalizable lessons that can inform the evolution and expansion of this approach to value-based payment in other states and settings.
View article: Time‐Varying Effects of Signs and Symptoms on Pregnancy Loss <20 Weeks: Findings from a Preconception Prospective Cohort Study
Time‐Varying Effects of Signs and Symptoms on Pregnancy Loss <20 Weeks: Findings from a Preconception Prospective Cohort Study Open
Background Although pregnancy loss affects one‐third of pregnancies, the associated signs/symptoms have not been fully described. Given the dynamic nature of maternal physiologic adaptation to early pregnancy, we posited the relationships …
View article: Group B Streptococcus and the Vaginal Microbiota
Group B Streptococcus and the Vaginal Microbiota Open
Vaginal microbiota CST and α-diversity are not related to GBS status. However, specific microbial taxa are associated with colonization of this important human pathogen, highlighting a potential role for the microbiota in promotion or inhi…
View article: Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer
Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer Open
Fecundity, the biologic capacity to reproduce, is essential for the health of individuals and is, therefore, fundamental for understanding human health at the population level. Given the absence of a population (bio)marker, fecundity is as…
View article: Reconstructing a Pregnancy Cohort to Examine Potential Selection Bias in Studies on Racial Disparities in Preterm Delivery
Reconstructing a Pregnancy Cohort to Examine Potential Selection Bias in Studies on Racial Disparities in Preterm Delivery Open
Background Epidemiologic studies examining preconception risk factors on perinatal outcomes are typically restricted to livebirths. By including only non‐terminated pregnancies, estimates for the underlying pregnancy cohort may be subject …
View article: Time-to-Pregnancy Associated With Couples’ Use of Tobacco Products
Time-to-Pregnancy Associated With Couples’ Use of Tobacco Products Open
Both partners' preconception smoking contributed to longer TTP, highlighting the importance of both partners' lifestyles in healthy reproduction and underscores the need for couple-based preconception guidance. The male's contribution is a…
View article: Choice of underwear and male fecundity in a preconception cohort of couples
Choice of underwear and male fecundity in a preconception cohort of couples Open
Summary Our objective was to investigate the relationship between male underwear‐type worn during daytime/bedtime and male fecundity as measured by semen quality and time‐to‐pregnancy. We used data from a prospective preconception cohort c…
View article: Signs and symptoms associated with early pregnancy loss: findings from a population-based preconception cohort
Signs and symptoms associated with early pregnancy loss: findings from a population-based preconception cohort Open
This study was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (contract numbers N01-HD-3-3355; N01-HD-3-3356; N01-HD-3-3358…
View article: The natural history of pregnancy loss
The natural history of pregnancy loss Open
Pregnancy loss, the demise of a pregnancy at any time between implantation and delivery, is a common event in women’s lives, affecting approximately one in three pregnancies. Pregnancy loss often causes profound psychological distress to w…