Kåre Buhlin
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View article: The association of periodontal inflammation and inflammatory markers with cognitive dysfunction: A case–control study
The association of periodontal inflammation and inflammatory markers with cognitive dysfunction: A case–control study Open
Background This study investigated the association of inflammatory markers in saliva, plasma, and cerebrospinal fluid (CSF) with cognitive decline and periodontitis. Methods Patients with Alzheimer disease (AD, n = 52), mild cognitive impa…
View article: Tooth Loss in Individuals with Dementia: A Swedish Register-Based Cohort Study
Tooth Loss in Individuals with Dementia: A Swedish Register-Based Cohort Study Open
Risk factors for dementia include cardiovascular disease, smoking, and diabetes, which also are linked to compromised oral health and periodontal disease. Tooth loss, the hallmark of compromised oral health, is of interest for its systemic…
View article: Does Toothache Before a Dental Visit Associate with the Risk of a First Myocardial Infarction?
Does Toothache Before a Dental Visit Associate with the Risk of a First Myocardial Infarction? Open
Background/Objectives: Ischemic heart disease is typically characterized by chest pain that sometimes radiate to other areas, including the orofacial region. Atypical clinical presentation of cardiac disease risks leading to a delay in the…
View article: Using Dental Register Information and Questionnaire Data to Assess Periodontitis in Large Cohort Studies
Using Dental Register Information and Questionnaire Data to Assess Periodontitis in Large Cohort Studies Open
Aim Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods Ma…
View article: Metabolic Profiling of Individuals with Missing Teeth and Tooth Loss
Metabolic Profiling of Individuals with Missing Teeth and Tooth Loss Open
Missing teeth have been linked to incident cardiovascular disease, diabetes, and all-cause mortality. Our previous study revealed that signs of oral infections and inflammatory conditions (i.e., periodontal disease and dental caries) are a…
View article: Does Periodontitis Increase the Risk for Future Cardiovascular Events? Long‐Term Follow‐Up of the <scp>PAROKRANK</scp> Study
Does Periodontitis Increase the Risk for Future Cardiovascular Events? Long‐Term Follow‐Up of the <span>PAROKRANK</span> Study Open
Background and Aim The study ‘Periodontitis and Its Relation to Coronary Artery Disease’ (PAROKRANK) reported an association between periodontitis (PD) and the first myocardial infarction (MI). This follow‐up study aims to test the hypothe…
View article: Endodontic Inflammatory Disease and Future Cardiovascular Events and Mortality: A Report from the PAROKRANK Study
Endodontic Inflammatory Disease and Future Cardiovascular Events and Mortality: A Report from the PAROKRANK Study Open
Tooth loss is a strong indicator of an increased risk for future cardiovascular events. Root-filled teeth seem of limited value as a risk indicator when accounting for other risk factors. The potential effect of dental interventions on fut…
View article: Systemic Metabolic Signatures of Oral Diseases
Systemic Metabolic Signatures of Oral Diseases Open
Systemic metabolic signatures of oral diseases have been rarely investigated, and prospective studies do not exist. We analyzed whether signs of current or past infectious/inflammatory oral diseases are associated with circulating metaboli…
View article: A Weighted Composite of Endodontic Inflammatory Disease is Linked to a First Myocardial Infarction.
A Weighted Composite of Endodontic Inflammatory Disease is Linked to a First Myocardial Infarction. Open
A weighted composite of EID was associated with the risk of MI and strengthens the evidence for a direct connection between oral inflammatory diseases and cardiovascular disorders.
View article: Primary apical periodontitis correlates to elevated levels of interleukin‐8 in a Swedish population: A report from the PAROKRANK study
Primary apical periodontitis correlates to elevated levels of interleukin‐8 in a Swedish population: A report from the PAROKRANK study Open
Aim To explore associations between root filled teeth, primary and secondary apical periodontitis, and levels of inflammatory markers in blood from patients with a first myocardial infarction and matched controls. Methodology Between May 2…
View article: Subgingival microbiome at different levels of cognition
Subgingival microbiome at different levels of cognition Open
Oral health and declining cognition may have a bi-directional association. We characterized the subgingival microbiota composition of subjects from normal cognition to severe cognitive decline in two cohorts. Memory and Periodontitis (MINO…
View article: Calcified carotid artery atheromas in individuals with cognitive dysfunction
Calcified carotid artery atheromas in individuals with cognitive dysfunction Open
Cognitively impaired patients do not have a higher burden of CCAA than matched controls without cognitive impairment.
View article: Effects of primary hyperparathyroidism on oral health. A longitudinal register‐based study
Effects of primary hyperparathyroidism on oral health. A longitudinal register‐based study Open
Objectives To analyze the effects of primary hyperparathyroidism on oral health and to investigate if the effects are linked to severity of the disease. Subjects and Methods This prospective cohort study involved 6151 primary hyperparathyr…
View article: Long-term prognosis after a first myocardial infarction: eight years follow up of the case-control study PAROKRANK
Long-term prognosis after a first myocardial infarction: eight years follow up of the case-control study PAROKRANK Open
Objective. To explore long-term cardiovascular outcomes and mortality in patients after a first myocardial infarction (MI) compared with matched controls in a contemporary setting. Methods. During 2010-2014 the Swedish study PAROKRANK recr…
View article: Common complement factor H polymorphisms are linked with periodontitis in elderly patients
Common complement factor H polymorphisms are linked with periodontitis in elderly patients Open
Background In our recent genome‐wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP‐8) concentration and…
View article: Systemic Antibiotics Influence Periodontal Parameters and Oral Microbiota, But Not Serological Markers
Systemic Antibiotics Influence Periodontal Parameters and Oral Microbiota, But Not Serological Markers Open
The use of systemic antibiotics may influence the oral microbiota composition. Our aim was to investigate in this retrospective study whether the use of prescribed antibiotics associate with periodontal status, oral microbiota, and antibod…
View article: Periodontitis and cardiovascular outcome – a prospective follow-up of the PAROKRANK cohort
Periodontitis and cardiovascular outcome – a prospective follow-up of the PAROKRANK cohort Open
Background There is an association between periodontitis (PD) and myocardial infarction (MI). Whether that is related to shared risk factors or it is causal is debated. The Periodontitis and Its Relation to Coronary Artery Disease (PAROKRA…
View article: Long term outcome after a first myocardial infarction
Long term outcome after a first myocardial infarction Open
Background Prognosis after a myocardial infarction (MI) have improved consistently over the last decades. In parallel, the incidence of cardiovascular (CV) events has been reduced and life expectancy in people free from CV disease improved…
View article: Endodontic inflammatory disease: A risk indicator for a first myocardial infarction
Endodontic inflammatory disease: A risk indicator for a first myocardial infarction Open
Aim To study the association between endodontic inflammatory disease and a first myocardial infarction (MI). Methodology The study comprised 805 patients with recent experience of a first MI, each gender, age and geographically matched wit…
View article: Radiographic peri-implant bone loss after a function time up to 15 years
Radiographic peri-implant bone loss after a function time up to 15 years Open
The presence of moderate-severe peri-implantitis at patient level was found to be a risk indicator of peri-implant bone loss in healthy implants, while smoking and general periodontitis Stages III and IV were risk indicators of moderate-se…
View article: Salivary IgA antibody to malondialdehyde–acetaldehyde associates with mild periodontal pocket depth
Salivary IgA antibody to malondialdehyde–acetaldehyde associates with mild periodontal pocket depth Open
Objective Oxidized epitopes such as malondialdehyde–acetaldehyde (MAA) play a crucial role in the progression of atherosclerosis through activation of the humoral immune response. The exact mechanism of the association between atherosclero…
View article: Calibration improves observer reliability in detecting periapical pathology on panoramic radiographs
Calibration improves observer reliability in detecting periapical pathology on panoramic radiographs Open
DMFT-score, remaining teeth and root-filled teeth can be reliably assessed on panoramic radiographs. Calibration against a reference standard improves observer reliability in the detection of periapical lesions.
View article: Ökad etnisk mångfald i de nordiska länderna – tandhälsoeffekter
Ökad etnisk mångfald i de nordiska länderna – tandhälsoeffekter Open
English summary Increasing ethnic diversity in the Nordic countries – oral health implications Nor Tannlegeforen Tid. 2021; 131: 54–60 Since the late 20th century, the inhabitants of Nordic countries have gradually shifted from being quite…
View article: Subgingival microbiota in a population with and without cognitive dysfunction
Subgingival microbiota in a population with and without cognitive dysfunction Open
Aim: The aim of this study was to compare the subgingival microbiota of people with Alzheimer´s disease (AD), mild cognitive impairment (MCI), subjective cognitive decline (SCD) and cognitively healthy individuals. Materials and methods: T…
View article: Adjunctive Antiseptic Irrigation of Periodontal Pockets: Effects on Microbial and Cytokine Profiles
Adjunctive Antiseptic Irrigation of Periodontal Pockets: Effects on Microbial and Cytokine Profiles Open
To evaluate the effect of adjunctive antiseptic irrigation of periodontal pockets on microbial and cytokine profiles. Fifty-nine patients with severe periodontitis were allocated to one of three groups for scaling and root planing facilita…
View article: Carotid artery calcification in panoramic radiographs associates with oral infections and mortality
Carotid artery calcification in panoramic radiographs associates with oral infections and mortality Open
Aim To study the prevalence of carotid artery calcification (CAC) in relation to apical and marginal periodontitis, subgingival dysbiotic bacterial species and serum and saliva immune responses against them. In addition, the aim was to ana…
View article: Immunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis
Immunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis Open
The cumulative risk score (CRS) is a mathematical salivary diagnostic model to define an individual’s risk of having periodontitis. In order to further validate this salivary biomarker, we investigated how periodontal bacteria, lipopolysac…
View article: Exposure to Aggregatibacter actinomycetemcomitans before Symptom Onset and the Risk of Evolving to Rheumatoid Arthritis
Exposure to Aggregatibacter actinomycetemcomitans before Symptom Onset and the Risk of Evolving to Rheumatoid Arthritis Open
Periodontal disease has been implicated in the pathogenesis of rheumatoid arthritis (RA), an autoimmune disease characterized by immune-mediated synovial damage, and antibodies to citrullinated antigens. Here, we investigate the associatio…