Karen Featherstone
YOU?
Author Swipe
View article: Transcription Factor Pit-1 Affects Transcriptional Timing in the Dual-Promoter Human Prolactin Gene
Transcription Factor Pit-1 Affects Transcriptional Timing in the Dual-Promoter Human Prolactin Gene Open
Gene transcription occurs in short bursts interspersed with silent periods, and these kinetics can be altered by promoter structure. The effect of alternate promoter architecture on transcription bursting is not known. We studied the human…
View article: Disentangling juxtacrine from paracrine signalling in dynamic tissue
Disentangling juxtacrine from paracrine signalling in dynamic tissue Open
Prolactin is a major hormone product of the pituitary gland, the central endocrine regulator. Despite its physiological importance, the cell-level mechanisms of prolactin production are not well understood. Having significantly improved th…
View article: Asymmetry between Activation and Deactivation during a Transcriptional Pulse
Asymmetry between Activation and Deactivation during a Transcriptional Pulse Open
Transcription in eukaryotic cells occurs in gene-specific bursts or pulses of activity. Recent studies identified a spectrum of transcriptionally active "on-states," interspersed with periods of inactivity, but these "off-states" and the p…
View article: Spatially coordinated dynamic gene transcription in living pituitary tissue
Spatially coordinated dynamic gene transcription in living pituitary tissue Open
Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living …
View article: Adult Pituitary Trypsin Treated Data2
Adult Pituitary Trypsin Treated Data2 Open
GFP fluorescence measured from single cells in adult pituitary tissue treated with trypsin for 2hrs prior to confocal imaging. Compare to Adult Pituitary Trypsin Untreated Data2.