Karen J. Cruickshanks
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View article: Risk factors for hearing impairment among adults with diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Risk factors for hearing impairment among adults with diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Open
View article: Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease
Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease Open
Aim: To determine whether exposure to neurotoxins in midlife is associated with changes in blood-based biomarkers of neurodegeneration and Alzheimer disease pathology. Methods: Blood cadmium, lead, neurofilament light (NfL) chain, total ta…
View article: Associations of Sensory and Motor Functions in Midlife with Longitudinal Blood‐Based Biomarker Levels of Alzheimer’s Disease and Neurodegeneration
Associations of Sensory and Motor Functions in Midlife with Longitudinal Blood‐Based Biomarker Levels of Alzheimer’s Disease and Neurodegeneration Open
Background Dementia has a long preclinical phase and pathological fluid biomarker levels change decades before clinical symptoms. Thus, early detection of people at risk for neurodegenerative and pathological changes, especially in midlife…
View article: Associations of Hearing Loss and Hearing Aid Use With Cognition, Health-Related Quality of Life, and Depressive Symptoms
Associations of Hearing Loss and Hearing Aid Use With Cognition, Health-Related Quality of Life, and Depressive Symptoms Open
Objectives Determine associations of hearing loss (HL) and hearing aid (HA) use with cognition, health-related quality of life (HRQoL), and depressive symptoms. Methods: Participants were from the Epidemiology of Hearing Loss Study or Beav…
View article: TEMPORAL ASSOCIATIONS OF SENSORY FUNCTION AND BLOOD-BASED NEURODEGENERATIVE AND ALZHEIMER'S DISEASE BIOMARKERS
TEMPORAL ASSOCIATIONS OF SENSORY FUNCTION AND BLOOD-BASED NEURODEGENERATIVE AND ALZHEIMER'S DISEASE BIOMARKERS Open
Sensory changes are risk factors of neurodegeneration and Alzheimer’s Disease (AD) but their relations with emerging blood-based biomarkers of neurodegeneration and AD are rather unknown. We assessed long-term temporal relationships of sen…
View article: Inflammation, metabolic dysregulation and environmental neurotoxins and risk of cognitive decline and impairment in midlife
Inflammation, metabolic dysregulation and environmental neurotoxins and risk of cognitive decline and impairment in midlife Open
View article: Associations of sensory and motor function with blood-based biomarkers of neurodegeneration and Alzheimer's disease in midlife
Associations of sensory and motor function with blood-based biomarkers of neurodegeneration and Alzheimer's disease in midlife Open
View article: Better cognitive function in younger generations - Insights from two cohort studies of middle-aged to older adults in Wisconsin
Better cognitive function in younger generations - Insights from two cohort studies of middle-aged to older adults in Wisconsin Open
View article: Association of Central Retinal Arteriolar and Venular Equivalents with Brain-aging and Macular Ganglion Cell-inner Plexiform Layer Thickness
Association of Central Retinal Arteriolar and Venular Equivalents with Brain-aging and Macular Ganglion Cell-inner Plexiform Layer Thickness Open
The association of CRAE with incident brain-aging indicates its potential use as a screening tool among those without eye disease. The associations between CRAE and CRVE and mGCIPL thickness indicate narrower vasculature could affect neuro…
View article: The pupil constriction to light is associated with cognitive measures in middle-aged and older adults
The pupil constriction to light is associated with cognitive measures in middle-aged and older adults Open
View article: Associations between Visual, Hearing Functioning and Cognitive Functioning among Hispanics/Latinos
Associations between Visual, Hearing Functioning and Cognitive Functioning among Hispanics/Latinos Open
Findings that visual impairment (VI) and hearing impairment (HI) are associated with cognitive functioning are drawn from studies that involved few Hispanic/Latino participants. We utilized data from the Miami Ocular SOL ancillary study to…
View article: Factors Affecting Hearing Aid Adoption by Adults With High-Frequency Hearing Loss: The Beaver Dam Offspring Study
Factors Affecting Hearing Aid Adoption by Adults With High-Frequency Hearing Loss: The Beaver Dam Offspring Study Open
Purpose: Hearing loss (HL) is common among middle-age and older adults, but hearing aid adoption is low. The purpose of this study was to measure the 10-year incidence of hearing aid adoption in a sample of primarily middle-age adults with…
View article: The Association of Psychological Well-Being With Sensory and Cognitive Function and Neuronal Health in Aging Adults
The Association of Psychological Well-Being With Sensory and Cognitive Function and Neuronal Health in Aging Adults Open
Objectives Psychological well-being (PWB) may be a potential modifiable risk factor of age-related diseases. We aimed to determine associations of PWB with sensorineural and cognitive function and neuronal health in middle-aged adults. Met…
View article: Benefit of Musical Training for Speech Perception and Cognition Later in Life
Benefit of Musical Training for Speech Perception and Cognition Later in Life Open
Purpose The aim of this study was to determine the long-term associations of musical training with speech perception in adverse conditions and cognition in a longitudinal cohort study of middle-age to older adults. Method This study is bas…
View article: Exposure to Cadmium, Lead, and Tobacco Smoke and the 10-Year Cumulative Incidence of Olfactory Impairment
Exposure to Cadmium, Lead, and Tobacco Smoke and the 10-Year Cumulative Incidence of Olfactory Impairment Open
Results of this longitudinal cohort study suggest that modifiable environmental exposures may contribute to olfactory impairment that occurs with aging. Identification of modifiable risk factors for olfactory impairment may lead to prevent…
View article: Factors Associated with the Macular Ganglion Cell–Inner Plexiform Layer Thickness in a Cohort of Middle-aged U.S. Adults
Factors Associated with the Macular Ganglion Cell–Inner Plexiform Layer Thickness in a Cohort of Middle-aged U.S. Adults Open
SIGNIFICANCE The macular ganglion cell–inner plexiform layer (mGCIPL) may serve as a quick and easily obtained measure of generalized neurodegeneration. Investigating factors associated with this thickness could help to understand neurodeg…
View article: Musical training, speech perception, and cognition (Merten et al., 2021)
Musical training, speech perception, and cognition (Merten et al., 2021) Open
Purpose: The aim of this study was to determine the long-term associations of musical training with speech perception in adverse conditions and cognition in a longitudinal cohort study of middle-age to older adults.Method: Th…
View article: Predicting hearing aid use in adults: the Beaver Dam Offspring Study
Predicting hearing aid use in adults: the Beaver Dam Offspring Study Open
Similar predictive abilities of models suggest audiological evaluations perform well in predicting HA use.
View article: Macular Ganglion Cell–Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife
Macular Ganglion Cell–Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife Open
Neurodegenerative diseases are public health challenges in aging populations. Early identification of people at risk for neurodegeneration might improve future treatment. Noninvasive, inexpensive screening tools are lacking but of great po…
View article: Incidence of Hearing Impairment and Changes in Pure-Tone Average Across Generations
Incidence of Hearing Impairment and Changes in Pure-Tone Average Across Generations Open
This study suggests that the risk of HI and rate of PTA change is lower for the Silent Generation and Baby Boom Generation compared with the Greatest Generation. Part of this lower risk is likely associated with changes in modifiable facto…
View article: Hearing Impairment Prevalence and Associated Risk Factors in the Hispanic Community Health Study/Study of Latinos
Hearing Impairment Prevalence and Associated Risk Factors in the Hispanic Community Health Study/Study of Latinos Open
Hearing impairment (HI) is a common problem in adults but there have been few studies of hearing in the U.S. Hispanic/Latino population. Little is known about factors associated with HI among Hispanics/Latinos.
View article: Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity
Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity Open
The risk of incident CS impairment decreased by birth cohort, with the greatest reduction in the Baby Boom Generation. The difference in risk suggests that there are unknown modifiable risk factors that may help to further explain the etio…
View article: Macular Ganglion Cell-Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife
Macular Ganglion Cell-Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife Open
Background Neurodegenerative diseases are public health challenges in aging populations. Early identification of people at risk for neurodegeneration might improve targeted treatment. Noninvasive, inexpensive screening tools are lacking bu…
View article: Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos
Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos Open
Sleep apnea (SA) may promote hearing impairment (HI) through ischemia and inflammation of the cochlea. Our objective was to assess an independent association between SA and HI in the Hispanic Community Health Study/Study of Latinos (HCHS/S…
View article: A Novel Method for Classifying Hearing Impairment in Epidemiological Studies of Aging: The Wisconsin Age-Related Hearing Impairment Classification Scale
A Novel Method for Classifying Hearing Impairment in Epidemiological Studies of Aging: The Wisconsin Age-Related Hearing Impairment Classification Scale Open
Purpose Longitudinal population-based cohort data were used to develop a standardized classification system for age-related hearing impairment using thresholds for frequencies (0.5–8 kHz) typically measured in cohort studies. Method Audiom…
View article: Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment
Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment Open
Previous research has shown that genes play a substantial role in determining a person’s susceptibility to age-related hearing impairment. The existing studies on this subject have different results, which may be caused by difficulties in …
View article: Cadmium, obesity, and education, and the 10‐year incidence of hearing impairment: The beaver dam offspring study
Cadmium, obesity, and education, and the 10‐year incidence of hearing impairment: The beaver dam offspring study Open
Objectives/Hypothesis To determine the 10‐year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle‐aged cohort followed for 10 years. Study Design Prospect…
View article: Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals
Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals Open
Background The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipop…
View article: Associations of Hearing Sensitivity, Higher-Order Auditory Processing, and Cognition Over Time in Middle-Aged Adults
Associations of Hearing Sensitivity, Higher-Order Auditory Processing, and Cognition Over Time in Middle-Aged Adults Open
Background Age-related hearing loss (impairment in hearing sensitivity and/or higher-order auditory processing) and cognitive decline are common co-occurring impairments in elderly adults. Their relation in the process of aging remains ins…
View article: Risk Factors for Hearing Impairment in Type 1 Diabetes
Risk Factors for Hearing Impairment in Type 1 Diabetes Open