Karen Kaiser
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View article: The Safety Action Feedback and Engagement (SAFE) Loop: Initial Testing and Refinement of a Novel Intervention to Enhance Hospital Incident Reporting and Patient Safety
The Safety Action Feedback and Engagement (SAFE) Loop: Initial Testing and Refinement of a Novel Intervention to Enhance Hospital Incident Reporting and Patient Safety Open
Background Voluntary incident reporting has improved safety in many high-risk industries, but several barriers have limited its effectiveness in hospitals. Designed to overcome these barriers, the novel Safety Action Feedback and Engagemen…
View article: Decision Aid for Pediatric Atopic Dermatitis
Decision Aid for Pediatric Atopic Dermatitis Open
A decision aid for children with atopic dermatitis can be used for clinical encounters and has the potential to improve patient/family engagement in decision-making. In addition, we include a worksheet on patient/parent values and an eczem…
View article: Content validation of the National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy Lymphoma Symptom Index-18 (NFLymSI-18) in indolent B-cell non-Hodgkin’s lymphoma
Content validation of the National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy Lymphoma Symptom Index-18 (NFLymSI-18) in indolent B-cell non-Hodgkin’s lymphoma Open
View article: A qualitative evaluation of factors influencing Tumor Treating fields (TTFields) therapy decision making among brain tumor patients and physicians
A qualitative evaluation of factors influencing Tumor Treating fields (TTFields) therapy decision making among brain tumor patients and physicians Open
Background Tumor Treating Fields (TTFields) Therapy is an FDA-approved therapy in the first line and recurrent setting for glioblastoma. Despite Phase 3 evidence showing improved survival with TTFields, it is not uniformly utilized. We aim…
View article: Web-Based Pain Coping Skills Training (Pcst) for Managing Aromatase Inhibitor-Associated Arthralgia in Breast Cancer Survivors: Randomized Controlled Trial Protocol
Web-Based Pain Coping Skills Training (Pcst) for Managing Aromatase Inhibitor-Associated Arthralgia in Breast Cancer Survivors: Randomized Controlled Trial Protocol Open
View article: Comparing the Safety Action Feedback and Engagement (SAFE) Loop with an established incident reporting system: Study protocol for a pragmatic cluster randomized controlled trial
Comparing the Safety Action Feedback and Engagement (SAFE) Loop with an established incident reporting system: Study protocol for a pragmatic cluster randomized controlled trial Open
BACKGROUND: Incident reporting is widely used in hospitals to improve patient safety, but current reporting systems do not function optimally. The utility of incident reports is limited because hospital staff may not know what to report, m…
View article: Integrating PROMIS Measures in a Treat-to-Target Approach to Standardize Patient-Centered Treatment of Rheumatoid Arthritis
Integrating PROMIS Measures in a Treat-to-Target Approach to Standardize Patient-Centered Treatment of Rheumatoid Arthritis Open
Objective To evaluate the effect of a patient-centered rheumatoid arthritis (RA) treat-to-target (T2T) disease management approach on patient outcomes and patient satisfaction with care. Methods In this longitudinal, observational pilot st…
View article: Medical Oncologists' Knowledge and Perspectives on the Use of Biosimilars in the United States
Medical Oncologists' Knowledge and Perspectives on the Use of Biosimilars in the United States Open
PURPOSE: Despite increasing availability of biosimilar cancer treatments, little is known about oncologists' knowledge and concerns regarding biosimilar use in the United States. We surveyed medical oncologists to examine their knowledge, …
View article: A Qualitative Study of Medical Oncologists’ Knowledge and Views of Biosimilars in the United States
A Qualitative Study of Medical Oncologists’ Knowledge and Views of Biosimilars in the United States Open
Background: As the cost of cancer care continues to rise, biosimilars provide an important cost-saving treatment option. Thus, understanding barriers to biosimilar uptake, including perceptions of biosimilars among oncologists, is critical…
View article: How do patients interpret and respond to a single-item global indicator of cancer treatment tolerability?
How do patients interpret and respond to a single-item global indicator of cancer treatment tolerability? Open
Background There is increasing interest in patient-reported measures of cancer treatment tolerability. A global measure of bother, the FACT GP5 item (“I am bothered by side effects of treatment”) is potentially useful for regulatory, resea…
View article: Qualitative development of the PROMIS Profile v1.0-Familial Chylomicronemia Syndrome (FCS) 28
Qualitative development of the PROMIS Profile v1.0-Familial Chylomicronemia Syndrome (FCS) 28 Open
View article: Optimizing a Behavioral Sleep Intervention for Gynecologic Cancer Survivors: Study Design and Protocol
Optimizing a Behavioral Sleep Intervention for Gynecologic Cancer Survivors: Study Design and Protocol Open
Sleep difficulties, particularly symptoms of insomnia and circadian disruption, are among the primary complaints of gynecologic cancer survivors before, during, and after treatment. Moreover, difficulty sleeping has been linked to poorer h…
View article: INNV-13. UNDERSTANDING FACTORS THAT INFLUENCE THE DECISION OF ACCEPTING TUMOR TREATING FIELDS (TTF) THERAPY
INNV-13. UNDERSTANDING FACTORS THAT INFLUENCE THE DECISION OF ACCEPTING TUMOR TREATING FIELDS (TTF) THERAPY Open
BACKGROUND Tumor Treating Fields (TTF) Therapy is an FDA-approved therapy in the first line and recurrent setting for glioblastoma. Despite Phase 3 evidence showing improved survival, it is not uniformly utilized despite its availability. …
View article: Patient preferences and quality of life implications of ravulizumab (every 8 weeks) and eculizumab (every 2 weeks) for the treatment of paroxysmal nocturnal hemoglobinuria
Patient preferences and quality of life implications of ravulizumab (every 8 weeks) and eculizumab (every 2 weeks) for the treatment of paroxysmal nocturnal hemoglobinuria Open
This study shows that a substantial proportion of patients preferred ravulizumab over eculizumab and provides an important patient perspective on PNH treatment when there is more than one treatment option.
View article: Medical oncologist perspectives on palliative care reveal physician-centered barriers to early integration
Medical oncologist perspectives on palliative care reveal physician-centered barriers to early integration Open
Medical oncologists are hesitant to adopt the practice of early palliative care referral because they are concerned that other physicians may disrupt a patient's treatment plan. Physician-centered barriers may delay integration of palliati…
View article: <p>Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Medication Adherence Scale (PMAS)</p>
Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Medication Adherence Scale (PMAS) Open
Poor medication adherence is associated with reduced drug effectiveness, poor health-related quality of life, increased morbidity and mortality, and increased healthcare utilization and cost. Including the patient's voice is essential in u…
View article: <p>Assessing Preferences for Rare Disease Treatment: Qualitative Development of the Paroxysmal Nocturnal Hemoglobinuria Patient Preference Questionnaire (PNH-PPQ©)</p>
Assessing Preferences for Rare Disease Treatment: Qualitative Development of the Paroxysmal Nocturnal Hemoglobinuria Patient Preference Questionnaire (PNH-PPQ©) Open
The PNH-PPQ provides a patient-centered approach for evaluating preferences for the treatment of PNH. The PNH-PPQ has subsequently assessed patient preference in the clinical trial sub-study ALXN1210-PNH-302s.
View article: Neuropathy experienced by colorectal cancer patients receiving oxaliplatin: A qualitative study to validate the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity scale
Neuropathy experienced by colorectal cancer patients receiving oxaliplatin: A qualitative study to validate the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity scale Open
The FACT/GOG-Ntx represents the key neuropathy experiences of CRC patients treated with oxaliplatin.
View article: Development, Validation, and Interpretation of the PROMIS Itch Questionnaire: A Patient-Reported Outcome Measure for the Quality of Life Impact of Itch
Development, Validation, and Interpretation of the PROMIS Itch Questionnaire: A Patient-Reported Outcome Measure for the Quality of Life Impact of Itch Open
View article: PF734 PATIENT PREFERENCES FOR THE TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: RESULTS OF A PATIENT SURVEY OF RAVULIZUMAB (ALXN1210) AND ECULIZUMAB
PF734 PATIENT PREFERENCES FOR THE TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: RESULTS OF A PATIENT SURVEY OF RAVULIZUMAB (ALXN1210) AND ECULIZUMAB Open
Background: Since 2007, eculizumab has transformed the management of paroxysmal nocturnal hemoglobinuria (PNH). However, it has a treatment burden associated with q2w dosing. Recently, the FDA approved ravulizumab for PNH treatment. Ravuli…
View article: Seizure burden in severe early‐life epilepsy: Perspectives from parents
Seizure burden in severe early‐life epilepsy: Perspectives from parents Open
Objectives Seizure burden is typically measured by seizure frequency yet it entails more than seizure counts, especially for people with severe epilepsies and their caregivers. We aimed to characterize the multi‐faceted nature of seizure b…
View article: What does risk of future cancer mean to breast cancer patients?
What does risk of future cancer mean to breast cancer patients? Open
View article: A Comprehensive Conceptual Model of the Experience of Chronic Itch in Adults
A Comprehensive Conceptual Model of the Experience of Chronic Itch in Adults Open
View article: Cancer experiences and health-related quality of life among racial and ethnic minority survivors of young adult cancer: a mixed methods study
Cancer experiences and health-related quality of life among racial and ethnic minority survivors of young adult cancer: a mixed methods study Open
View article: Health-related quality of life among women with ductal carcinoma<i>in situ</i>or early invasive breast cancer: validation of the FACT-B (version 4)
Health-related quality of life among women with ductal carcinoma<i>in situ</i>or early invasive breast cancer: validation of the FACT-B (version 4) Open
Objectives: To examine the reliability and validity of the Functional Assessment of Cancer Therapy-Breast (FACT-B) Version 4.Methods: Women ≥ 40 years with DCIS or early invasive breast cancer treated with whole breast irradiation (n=280) …
View article: Awareness of preventive medication among women at high risk for breast cancer and their willingness to consider transdermal or oral tamoxifen: a focus group study
Awareness of preventive medication among women at high risk for breast cancer and their willingness to consider transdermal or oral tamoxifen: a focus group study Open
Awareness of preventive medications was low even in a highly educated sample of high-risk women. If given a choice in the route of administration, most women preferred a gel to a pill, anticipating fewer side effects. Future work should fo…
View article: Development and validation of the functional assessment of cancer therapy–antiangiogenesis subscale
Development and validation of the functional assessment of cancer therapy–antiangiogenesis subscale Open
The Functional Assessment of Cancer Therapy ( FACT )–Antiangiogenesis (AntiA) Subscale was developed and validated to enhance treatment decision‐making and side effect management for patients receiving anti‐angiogenesis therapies. Side eff…
View article: The impact of programs, practices, and strategies on student academic performance: a case study
The impact of programs, practices, and strategies on student academic performance: a case study Open
The purpose of this case study was to examine an urban middle school demonstrating significant student academic achievement gains, seeking to identify key programs, practices, and instructional strategies that have made a positive impact o…