Karen L. Gamble
YOU?
Author Swipe
View article: Study protocol: Using ecological momentary assessment and wearable sensors to examine mechanisms linking sleep and smoking cessation among adults who are socioeconomically disadvantaged
Study protocol: Using ecological momentary assessment and wearable sensors to examine mechanisms linking sleep and smoking cessation among adults who are socioeconomically disadvantaged Open
Background Cigarette smoking is highly concentrated among individuals with lower socioeconomic status (SES) who often lack access to smoking cessation services. Thus, smoking cessation in lower SES adults remains a critical public health c…
View article: Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD)
Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD) Open
Objectives This study evaluated the efficacy of ramelteon for insomnia in adult subjects with ADHD. Experimental Design For this randomized, double-blind, placebo-controlled crossover trial, 8 mg of ramelteon was given nightly, within thre…
View article: The molecular clock drives motivated locomotion and time-of-day-dependent firing patterns in mouse dopaminergic neurons
The molecular clock drives motivated locomotion and time-of-day-dependent firing patterns in mouse dopaminergic neurons Open
Though circadian locomotor rhythms are primarily driven by the suprachiasmatic nucleus, voluntary motor behavior also requires dopaminergic neuron (DAN) activity. However, it is unknown whether DAN molecular and electrophysiological proper…
View article: Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report
Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report Open
The circadian system maintains optimal biological functions at the appropriate time of day, and the disruption of this organization can contribute to the pathogenesis of cardiometabolic disorders. The timing of eating is a prominent extern…
View article: Conditional <i>Dystrophin</i> ablation causes profound effects on muscle development, neurobehavior, and extracellular matrix pathways
Conditional <i>Dystrophin</i> ablation causes profound effects on muscle development, neurobehavior, and extracellular matrix pathways Open
Dystrophin is an essential protein for regulating the transmission of intracellular force to the extracellular matrix within the skeletal muscle. The mammalian dystrophin gene ( Dmd ) is X-linked and has several isoforms with tissue-specif…
View article: Time-restricted feeding reduces cardiovascular disease risk in obese mice
Time-restricted feeding reduces cardiovascular disease risk in obese mice Open
Disrupted feeding and fasting cycles as well as chronic high-fat diet-induced (HFD-induced) obesity are associated with cardiovascular disease risk factors. We designed studies that determined whether 2 weeks of time-restricted feeding (TR…
View article: High-Salt Diet Increases Suprachiasmatic Neuronal Excitability Through Endothelin Receptor Type B Signaling
High-Salt Diet Increases Suprachiasmatic Neuronal Excitability Through Endothelin Receptor Type B Signaling Open
Circadian rhythms are 24-h oscillations in behavioral and biological processes such as blood pressure and sodium excretion. Endothelin B (ETB) receptor has been connected to the molecular clock in peripheral tissues and plays a key role in…
View article: Cortico-amygdala synaptic structural abnormalities produced by templated aggregation of α-synuclein
Cortico-amygdala synaptic structural abnormalities produced by templated aggregation of α-synuclein Open
Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) are characterized by neuronal α-synuclein (α-syn) inclusions termed Lewy Pathology, which are abundant in the amygdala. The basolateral amygdala (BLA), in particular, receives pr…
View article: Novel, nurse-led early postdischarge clinic is associated with fewer readmissions and lower mortality following hospitalisation with decompensated cirrhosis
Novel, nurse-led early postdischarge clinic is associated with fewer readmissions and lower mortality following hospitalisation with decompensated cirrhosis Open
Objective Patients hospitalised with decompensated cirrhosis have high rates of early unplanned readmission. Many readmissions are avoidable with secondary preventative strategies, but patients are often readmitted prior to outpatient revi…
View article: Circadian regulation of dentate gyrus excitability mediated by G-protein signaling
Circadian regulation of dentate gyrus excitability mediated by G-protein signaling Open
The central circadian regulator within the suprachiasmatic nucleus transmits time of day information by a diurnal spiking rhythm driven by molecular clock genes controlling membrane excitability. Most brain regions, including the hippocamp…
View article: Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report
Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report Open
Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been linked to ad…
View article: Examination of Diurnal Variation and Sex Differences in Hippocampal Neurophysiology and Spatial Memory
Examination of Diurnal Variation and Sex Differences in Hippocampal Neurophysiology and Spatial Memory Open
Circadian rhythms are biological processes that cycle across 24 h and regulate many facets of neurophysiology, including learning and memory. Circadian variation in spatial memory task performance is well documented; however, the effect of…
View article: Circadian regulation of dentate gyrus excitability mediated by G-protein signaling
Circadian regulation of dentate gyrus excitability mediated by G-protein signaling Open
Summary The central circadian regulator within the suprachiasmatic nucleus transmits time of day information by a diurnal spiking rhythm that is driven by intrinsic activity of molecular clock genes controlling membrane excitability. Most …
View article: 0683 Smoking and Perceived Stress: Examining Associations with Subjective Symptoms of Obstructive Sleep Apnea through Parallel Mediation Analyses
0683 Smoking and Perceived Stress: Examining Associations with Subjective Symptoms of Obstructive Sleep Apnea through Parallel Mediation Analyses Open
Introduction Cigarette smoking is known to have a negative effect on individuals’ sleep quality. Specifically, evidence shows that smoking can exacerbate sleep disorders such as obstructive sleep apnea (OSA) by increasing irritation and in…
View article: Nightshift Work and Nighttime Eating Are Associated With Higher Insulin and Leptin Levels in Hospital Nurses
Nightshift Work and Nighttime Eating Are Associated With Higher Insulin and Leptin Levels in Hospital Nurses Open
Background Circadian misalignment between behaviors such as feeding and endogenous circadian rhythms, particularly in the context of shiftwork, is associated with poorer cardiometabolic health. We examined whether insulin and leptin levels…
View article: Examination of diurnal variation and sex differences in hippocampal neurophysiology and spatial memory
Examination of diurnal variation and sex differences in hippocampal neurophysiology and spatial memory Open
Circadian rhythms are biological processes that cycle across 24 hours and regulate many facets of neurophysiology, including learning and memory. Circadian variation in performance on spatial memory tasks is well-documented; however, the e…
View article: Short-term daytime restricted feeding in rats with high salt impairs diurnal variation of Na<sup>+</sup>excretion
Short-term daytime restricted feeding in rats with high salt impairs diurnal variation of Na<sup>+</sup>excretion Open
Timing of food intake normally has little effect on the diurnal pattern of Na + and water excretion. However, rats on a high-salt diet were unable to maintain this pattern, yet K + excretion was more readily adjusted to match timing of int…
View article: O03 A novel nurse-led early post-discharge clinic is associated with fewer readmissions and lower mortality following an index hospitalisation with decompensated cirrhosis
O03 A novel nurse-led early post-discharge clinic is associated with fewer readmissions and lower mortality following an index hospitalisation with decompensated cirrhosis Open
Background Patients hospitalised with decompensated cirrhosis (jaundice, variceal bleeding, ascites or hepatic encephalopathy) have high rates of early, unplanned readmission, associated with increased complications and healthcare costs. O…
View article: Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina
Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina Open
Hypothalamic inflammation and sympathetic nervous system hyperactivity are hallmark features of metabolic syndrome and type 2 diabetes. Hypothalamic inflammation may aggravate metabolic and immunologic pathologies due to extensive sympathe…