Karen R. Jonscher
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View article: Maternal western-style diet alters Kupffer cell proportion leading to metabolic dysfunction-associated steatotic liver disease when challenged with western diet in adulthood
Maternal western-style diet alters Kupffer cell proportion leading to metabolic dysfunction-associated steatotic liver disease when challenged with western diet in adulthood Open
Exposure to maternal western-style diet (mWD) is associated with early development of metabolic dysfunction-associated fatty liver disease (MAFLD) in offspring. Kupffer cells (KCs), the main resident macrophage population in the liver, are…
View article: A role for the antioxidants coenzyme Q10 and pyrroloquinoline quinone in mitigating obesity-associated reproductive dysfunction
A role for the antioxidants coenzyme Q10 and pyrroloquinoline quinone in mitigating obesity-associated reproductive dysfunction Open
Obesity is a rising public health concern in the United States, with significant implications for maternal and fetal health during pregnancy. Maternal obesity is associated with increased risks of miscarriage, reduced implantation and preg…
View article: Maternal Western diet increases inflammatory markers and decreases barrier function of offspring in <i>Papio anubis</i>
Maternal Western diet increases inflammatory markers and decreases barrier function of offspring in <i>Papio anubis</i> Open
Our research examines a currently understudied area of the maternal/fetal relationship. This is especially pertinent, given the rampant access to high-fat/high-sugar foods in the Western diet. It is also noteworthy due to the findings of d…
View article: Reprogramming Offspring Liver Health: Maternal Indole Supplementation as a Preventive Strategy Against MASLD
Reprogramming Offspring Liver Health: Maternal Indole Supplementation as a Preventive Strategy Against MASLD Open
View article: Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response
Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response Open
Maternal obesity and/or Western diet (WD) is associated with an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in offspring, driven, in part, by the dysregulation of the early life microbiome. Here, usin…
View article: Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response
Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response Open
Maternal obesity and/or Western diet (WD) is associated with increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in offspring, driven, in part, by dysregulation of the early life microbiome. Here, using a mou…
View article: Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver Open
Maternal consumption of a high-fat, Western-style diet (WD) disrupts the maternal/infant microbiome and contributes to developmental programming of the immune system and nonalcoholic fatty liver disease (NAFLD) in the offspring. Epigenetic…
View article: Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes
Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes Open
The immune system of some genetically susceptible children can be triggered by certain environmental factors to produce islet autoantibodies (IA) against pancreatic β cells, which greatly increases their risk for Type-1 diabetes. An enviro…
View article: Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD
Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD Open
Maternal obesity and consumption of a high-fat diet significantly elevate risk for pediatric nonalcoholic fatty liver disease (NAFLD), affecting 10% of children in the US. Almost half of these children are diagnosed with nonalcoholic steat…
View article: Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver Open
Maternal consumption of a high-fat, Western-style diet (WD) disrupts the maternal/infant microbiome and contributes to developmental programming of the immune system and nonalcoholic fatty liver disease (NAFLD) in the offspring. Epigenetic…
View article: Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention
Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention Open
Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflam…
View article: Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD
Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD Open
Pediatric nonalcoholic fatty liver disease (NAFLD) affects 1 in 10 children in the US, increases risk of cirrhosis and transplantation in early adulthood, and shortens lifespan, even after transplantation. Exposure to maternal obesity and/…
View article: Spaceflight Activates Lipotoxic Pathways in Mouse Liver
Spaceflight Activates Lipotoxic Pathways in Mouse Liver Open
Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexpl…
View article: Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?
Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? Open
The Space Shuttle Atlantis launched on its final mission (STS-135) on July 8, 2011. After just under 13 days, the shuttle landed safely at Kennedy Space Center (KSC) for the last time. Female C57BL/6J mice flew as part of the Commercial Bi…
View article: Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice
Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice Open
Increasingly, evidence suggests that exposure to maternal obesity creates an inflammatory environment in utero , exerting long‐lasting postnatal signatures on the juvenile innate immune system and microbiome that may predispose offspring t…
View article: Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver
Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver Open
Increased oxidative stress is an unavoidable consequence of exposure to the space environment. Our previous studies showed that mice exposed to space for 13.5 days had decreased glutathione levels, suggesting impairments in oxidative defen…
View article: Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?
Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? Open
The Space Shuttle Atlantis launched on its final mission (STS-135) on July 8, 2011. After just under 13 days, the shuttle landed safely at Kennedy Space Center (KSC) for the last time. Female C57BL/6J mice flew as part of the Commercial Bi…
View article: Early PQQ supplementation has persistent long‐term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice
Early PQQ supplementation has persistent long‐term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice Open
Nonalcoholic fatty liver disease (NAFLD) is widespread in adults and children. Early exposure to maternal obesity or Western‐style diet (WD) increases steatosis and oxidative stress in fetal liver and is associated with lifetime disease ri…
View article: Mindfulness-Based Stress Reduction for Military Women With Chronic Pelvic Pain: A Feasibility Study
Mindfulness-Based Stress Reduction for Military Women With Chronic Pelvic Pain: A Feasibility Study Open
A standard MBSR program is difficult to implement in a military population; other delivery formats should be considered. There was a trend suggestive that program participation promotes mindfulness, reduces pain, and promotes modulation of…
View article: Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver
Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver Open
[This corrects the article DOI: 10.1371/journal.pone.0152877.].
View article: Spaceflight Activates Lipotoxic Pathways in Mouse Liver
Spaceflight Activates Lipotoxic Pathways in Mouse Liver Open
Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexpl…
View article: Annexin A2 Enhances Complement Activation by Inhibiting Factor H
Annexin A2 Enhances Complement Activation by Inhibiting Factor H Open
Factor H is a circulating protein that regulates activation of the alternative pathway (AP) of complement. Mutations and genetic variations of factor H are associated with several AP-mediated diseases, highlighting the critical role of fac…