Karen Sugden
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View article: The role of the ‘word gap’ for the intergenerational transmission of education: A genetically sensitive study
The role of the ‘word gap’ for the intergenerational transmission of education: A genetically sensitive study Open
Children experience large differences in language learning opportunities during the early years. These differences include their mothers’ vocabulary sophistication, which may serve as a pathway for the transmission of educational attainmen…
View article: An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference
An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference Open
Polygenic indexes (PGIs) — DNA-based predictors of individual phenotypes — have become essential tools across biomedical and social sciences. We introduce Version 2 of the Polygenic Index Repository, which expands phenotype coverage from 4…
View article: Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes
Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes Open
View article: The role of the ‘word gap’ for the intergenerational transmission of education: A genetically sensitive study
The role of the ‘word gap’ for the intergenerational transmission of education: A genetically sensitive study Open
Children experience large differences in language learning opportunities during the early years. These differences include their mothers’ vocabulary sophistication, which may serve as a pathway for the transmission of educational attainmen…
View article: Correction: DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort
Correction: DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort Open
View article: DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease
DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease Open
View article: DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort
DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort Open
View article: Quantifying the impact of early-life growth adversity on later-life health
Quantifying the impact of early-life growth adversity on later-life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
View article: An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference
An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference Open
Polygenic indexes (PGIs) — DNA-based predictors of individual phenotypes — have become essential tools across biomedical and social sciences. We introduce Version 2 of the Polygenic Index Repository, which expands phenotype coverage from 4…
View article: Examining the relationship between plasma pTau181 and cognitive decline, structural brain integrity, and biological ageing in midlife
Examining the relationship between plasma pTau181 and cognitive decline, structural brain integrity, and biological ageing in midlife Open
INTRODUCTION Although plasma pTau181 has been shown to accurately discriminate patients with Alzheimer’s disease from healthy older adults, its utility as a preclinical biomarker in middle-aged community-based cohorts is unclear. METHODS P…
View article: Cross‐tissue comparison of epigenetic aging clocks in humans
Cross‐tissue comparison of epigenetic aging clocks in humans Open
Epigenetic clocks are a common group of tools used to measure biological aging—the progressive deterioration of cells, tissues, and organs. Epigenetic clocks have been trained almost exclusively using blood‐based tissues, but there is grow…
View article: Accelerated epigenetic aging and prospective morbidity and mortality among U.S. veterans
Accelerated epigenetic aging and prospective morbidity and mortality among U.S. veterans Open
Epigenetic measures of aging derived from DNA methylation are promising biomarkers associated with prospective morbidity and mortality, but require validation in real-world medical settings. Using data from 2,216 post-9/11 veterans, we exa…
View article: Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort
Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort Open
INTRODUCTION The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. METHODS We analyzed Framingham Heart Study Offspring Cohort data ( n = 2296; 46% male; baseline age M = 62, SD = 9, range = 25…
View article: An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality
An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality Open
To understand how aging affects functional decline and increases disease risk, it is necessary to develop accurate and reliable measures of how fast a person is aging. Epigenetic clocks measure aging but require DNA methylation data, which…
View article: Cross-Tissue Comparison of Epigenetic Aging Clocks in Humans
Cross-Tissue Comparison of Epigenetic Aging Clocks in Humans Open
Epigenetic clocks are a common group of tools used to measure biological aging – the progressive deterioration of cells, tissues and organs. Epigenetic clocks have been trained almost exclusively using blood-based tissues but there is grow…
View article: Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort
Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort Open
Introduction The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. Methods We analyzed Framingham Heart Study Offspring Cohort data (n=2,296; 46% male; baseline age M =62, SD=9, range=25-101y).…
View article: Issue Information
Issue Information Open
OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries and enabling more researchers to publish open access by providing
View article: Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes
Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes Open
Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder for which genetic factors explain up to 75% of the variance. In this study, we performed a genome-wide association meta-analysis (GWAMA) of ADHD sym…
View article: Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study
Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study Open
Importance People who complete more education live longer lives with better health. New evidence suggests that these benefits operate through a slowed pace of biological aging. If so, measurements of the pace of biological aging could offe…
View article: Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study
Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study Open
Objective People who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the…
View article: Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood
Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood Open
View article: Educational Mobility, the Pace of Biological Aging, and Lifespan in the Framingham Heart Study
Educational Mobility, the Pace of Biological Aging, and Lifespan in the Framingham Heart Study Open
Importance People who complete more education live longer lives with better health. New evidence suggests that these benefits operate through a slowed pace of biological aging. If so, measurements of the pace biological aging could offer i…
View article: Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies
Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies Open
View article: A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohorts
A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohorts Open
Biological aging is the correlated decline of multi-organ system integrity central to the etiology of many age-related diseases. A novel epigenetic measure of biological aging, DunedinPACE, is associated with cognitive dysfunction, inciden…
View article: Genetic associations with parental investment from conception to wealth inheritance in six cohorts
Genetic associations with parental investment from conception to wealth inheritance in six cohorts Open
Genetic inheritance is not the only way parents’ genes may affect children. It is also possible that parents’ genes are associated with investments into children’s development. We examined evidence for links between parental genetics and p…
View article: Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study
Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study Open
INTRODUCTION We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging. METHODS We analyzed Framingham Offspring Cohort data (≥60y). We measured healthy diet using the Dietary Guidel…
View article: A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator
A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator Open
Background The field of epigenomics holds great promise in understanding and treating disease with advances in machine learning (ML) and artificial intelligence being vitally important in this pursuit. Increasingly, research now utilises D…
View article: Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals
Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals Open
Objectives Individuals with more education are at lower risk of developing multiple, different age-related diseases than their less-educated peers. A reason for this might be that individuals with more education age slower. There are 2 com…
View article: Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort
Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort Open
Background and Hypothesis Children exposed to socioenvironmental adversities (eg, urbanicity, pollution, neighborhood deprivation, crime, and family disadvantage) are more likely to subsequently develop subclinical psychotic experiences du…
View article: Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis Open