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View article: Lymfactin® gene therapy with vascularized lymph node transfer reduces compression-free swelling and enhances quality of life in breast cancer-related lymphedema: Final Phase I trial results
Lymfactin® gene therapy with vascularized lymph node transfer reduces compression-free swelling and enhances quality of life in breast cancer-related lymphedema: Final Phase I trial results Open
This prospective multicenter study demonstrated that Lymfactin® with VLNT is safe and well tolerated. Although volume reduction was most evident in the first year, half of the patients reduced or discontinued compression use, and quality o…
View article: Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth
Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth Open
We used intramuscular and systemic adeno-associated viral vector (AAV) gene delivery of myostatin propeptide (Pro-MSTN) and vascular endothelial growth factor B (VEGF-B) to induce muscle growth and angiogenesis in skeletal muscle. The intr…
View article: Beneficial effects of vascular endothelial growth factor B gene transfer in the aged heart
Beneficial effects of vascular endothelial growth factor B gene transfer in the aged heart Open
Aims Members of the VEGF family are crucial modulators of vascular and neural function. While VEGFA signalling has been shown to mitigate several aging-related cardiac phenotypes and prolong survival in aged mice, the role of VEGFB in card…
View article: Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema
Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema Open
BACKGROUND: Lymphedema is an incurable disease associated with lymphatic dysfunction that causes tissue swelling and fibrosis. We investigated whether lymphedema could be attenuated by interfering with uPARAP (urokinase plasminogen activat…
View article: A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer
A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer Open
Colorectal cancer progression is associated with an increase in PROX1+ tumor cells, which exhibit features of colorectal cancer stem cells and contribute to metastasis. Here, we aimed to provide a better understanding of the function of PR…
View article: Direct specification of lymphatic endothelium from mesenchymal progenitors
Direct specification of lymphatic endothelium from mesenchymal progenitors Open
View article: Targeting de novo cholesterol synthesis in rhabdomyosarcoma induces cell cycle arrest and triggers apoptosis through ER stress-mediated pathways
Targeting de novo cholesterol synthesis in rhabdomyosarcoma induces cell cycle arrest and triggers apoptosis through ER stress-mediated pathways Open
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, but the outcomes of high-grade RMS patients remain poor, underscoring the critical need for novel therapeutic strategies. Although metabolic pathways in RMS are inc…
View article: Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma
Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma Open
View article: Multi‐omics characterization of lymphedema‐induced adipose tissue resulting from breast cancer‐related surgery
Multi‐omics characterization of lymphedema‐induced adipose tissue resulting from breast cancer‐related surgery Open
Secondary lymphedema (LE) following breast cancer‐related surgery is a life‐long complication, which currently has no cure. LE induces significant regional adipose tissue deposition, requiring liposuction as a treatment. Here, we aimed to …
View article: The Impact of VEGF-C-Induced Dural Lymphatic Vessel Growth on Ischemic Stroke Pathology
The Impact of VEGF-C-Induced Dural Lymphatic Vessel Growth on Ischemic Stroke Pathology Open
Timely relief of edema and clearance of waste products, as well as promotion of anti-inflammatory immune responses, reduce ischemic stroke pathology, and attenuate harmful long-term effects post-stroke. The discovery of an extensive and fu…
View article: Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema
Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema Open
Primary lymphedema (PL), characterized by tissue swelling, fat accumulation, and fibrosis, results from defects in lymphatic vessels or valves caused by mutations in genes involved in development, maturation, and function of the lymphatic …
View article: Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy
Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy Open
BACKGROUND: Preclinical studies have shown the therapeutic potential of VEGF-B (vascular endothelial growth factor B) in revascularization of the ischemic myocardium, but the associated cardiac hypertrophy and adverse side effects remain a…
View article: Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology Open
View article: VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model Open
Meningeal lymphatic vessels (MLVs) promote tissue clearance and immune surveillance in the central nervous system (CNS). Vascular endothelial growth factor-C (VEGF-C) regulates MLV development and maintenance and has therapeutic potential …
View article: Yoda1 opens the lymphatic path for craniosynostosis therapy
Yoda1 opens the lymphatic path for craniosynostosis therapy Open
The rediscovery of meningeal lymphatic vessels (MLVs) has sparked research interest in their function in numerous neurological pathologies. Craniosynostosis (CS) is caused by a premature fusion of cranial sutures during development. In thi…
View article: Multi-omics characterization of lymphedema-induced adipose tissue from breast cancer patients
Multi-omics characterization of lymphedema-induced adipose tissue from breast cancer patients Open
Objective Secondary lymphedema (LE) following breast cancer surgery is a life-long complication, which currently has no cure. LE induces significant regional adipose tissue deposition, requiring liposuction as a treatment. Here, we aimed t…
View article: Distinct Molecular Profiles and Drug Vulnerabilities in Pancreatic Metastases of Renal Cell Carcinoma
Distinct Molecular Profiles and Drug Vulnerabilities in Pancreatic Metastases of Renal Cell Carcinoma Open
Pancreatic metastases (PM) of clear cell renal cell carcinoma (ccRCC) are rare, and little is known about them at patient level. The aim of this study was to define the patient-specific characteristics of PM-ccRCC and matching patient-deri…
View article: MITOCHONDRIAL DYSFUNCTION-INDUCED ASTROCYTE REACTIVATION: A NEW MECHANISM UNDERLYING NEOVASCULAR RETINOPATHY
MITOCHONDRIAL DYSFUNCTION-INDUCED ASTROCYTE REACTIVATION: A NEW MECHANISM UNDERLYING NEOVASCULAR RETINOPATHY Open
View article: Molecular anatomy of adult mouse leptomeninges
Molecular anatomy of adult mouse leptomeninges Open
Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has long been debated. In this study, we identify five molecularly d…
View article: Immunoliposomes for detection of rupture-prone intracranial aneurysms
Immunoliposomes for detection of rupture-prone intracranial aneurysms Open
Background It is estimated that significant (3.2%) of population carries intracranial aneurysm (IA). An increasing number of imaging studies have caused that the chance of finding an incidental aneurysm is becoming more common. Since IA ru…
View article: Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption
Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption Open
Background: Lymphatic vessels are responsible for tissue drainage, and their malfunction is associated with chronic diseases. Lymph uptake occurs via specialized open cell-cell junctions between capillary lymphatic endothelial cells (LECs)…
View article: Correction: EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory
Correction: EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory Open
View article: Specialized mesenteric lymphatic capillaries by-pass the mesenteric lymph node chain to transport peritoneal antigens directly into mediastinal lymph nodes
Specialized mesenteric lymphatic capillaries by-pass the mesenteric lymph node chain to transport peritoneal antigens directly into mediastinal lymph nodes Open
Lymphatic vessels (LVs) are indispensable for tissue fluid homeostasis and immune cell trafficking. The network of LVs that channel fluids from the gut into mesenteric lymph nodes (MLN) has been recognized as the sole lymphatic system in t…
View article: Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2
Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2 Open
BACKGROUND: Vascular growth followed by vessel specification is crucial for the establishment of a hierarchical blood vascular network. We have shown that TIE2 is required for vein development while little is known about its homologue TIE1…
View article: VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes
VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes Open
Meningeal lymphatic vessels promote tissue clearance and immune surveillance in the central nervous system (CNS). Vascular endothelium growth factor-C (VEGF-C) is essential for meningeal lymphatic development and maintenance and has therap…
View article: Comparison of Automated and Traditional Western Blotting Methods
Comparison of Automated and Traditional Western Blotting Methods Open
Traditional Western blotting is one of the most used analytical techniques in biological research. However, it can be time-consuming and suffer from a lack of reproducibility. Consequently, devices with different degrees of automation have…
View article: Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models
Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models Open
View article: Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation
Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation Open
The recent discovery of lymphatic vessels (LVs) in the dura mater, the outermost layer of meninges around the central nervous system (CNS), has opened a possibility for the development of alternative therapeutics for CNS disorders. The vas…
View article: <scp>STAT5b</scp>is a key effector of<scp>NRG</scp>‐1/<scp>ERBB4</scp>‐mediated myocardial growth
<span>STAT5b</span>is a key effector of<span>NRG</span>‐1/<span>ERBB4</span>‐mediated myocardial growth Open
View article: Supplementary Figure S2 from Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation
Supplementary Figure S2 from Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation Open
Supplementary Figure S2