Karim Keshavjee
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View article: Modeling the cumulative benefits of regular physical activity on type 2 diabetes progression
Modeling the cumulative benefits of regular physical activity on type 2 diabetes progression Open
Despite the well-acknowledged benefits of physical activity for type 2 diabetes (T2D) prevention, the literature lacks validated models able to predict the long-term benefits of exercise on T2D progression and that could be used to support…
View article: Economic evaluation of a digital health intervention for preventing dementia in Canadians with mild cognitive impairment
Economic evaluation of a digital health intervention for preventing dementia in Canadians with mild cognitive impairment Open
Dementia poses an on-going Canadian challenge due to an aging population, with cases projected to rise significantly by 2050. This study evaluates the cost-effectiveness of a conceptual digital health intervention designed to prevent demen…
View article: Mapping Neighborhood-Level Drivers of Type 2 Diabetes: A Predictive-Causal Approach for Precision Public Health
Mapping Neighborhood-Level Drivers of Type 2 Diabetes: A Predictive-Causal Approach for Precision Public Health Open
Type 2 diabetes has become an urban epidemic influenced by neighbourhood environments. However, conventional risk models focusing solely on individual factors fail to account for these community influences and often require detailed patien…
View article: Workplace inequities and health outcomes among Black professionals in Canada
Workplace inequities and health outcomes among Black professionals in Canada Open
Background Anti-Black racism in Canada remains a significant barrier to the career advancement and overall well-being of Black professionals. Despite the existence of policies and legislation aimed at reducing workplace discrimination, Bla…
View article: A Combined Predictive and Causal Approach for Neighborhood-Level Diabetes Detection
A Combined Predictive and Causal Approach for Neighborhood-Level Diabetes Detection Open
Objective: Develop a neighborhood-level framework using machine learning and causal inference to identify socioeconomic and behavioral drivers of Type 2 diabetes for targeted public health interventions. Materials and Methods: Data from 1,…
View article: System Dynamics Modeling for Diabetes Treatment and Prevention Planning
System Dynamics Modeling for Diabetes Treatment and Prevention Planning Open
The increasing prevalence of preventable chronic disease in Canada poses significant challenges to both healthcare budgets and individual financial stability. New treatments and predictive technologies are creating an urgent need to evalua…
View article: Competing Visions for the Soul of Canada’s Health and Healthcare System
Competing Visions for the Soul of Canada’s Health and Healthcare System Open
Canada’s healthcare system faces a critical choice between two futures: “Cyborgville,” driven by advanced medical technologies and AI, or a wellness-focused approach inspired by Blue Zones, which emphasize healthy lifestyles and environmen…
View article: Designing a Solution Framework for a Sickle Cell Disease Registry in Kenya: Transforming Patient Care
Designing a Solution Framework for a Sickle Cell Disease Registry in Kenya: Transforming Patient Care Open
Sickle Cell Disease (SCD) poses a significant healthcare challenge in Kenya, with about 14,000 new cases annually. Fragmented data collection hampers patient management, research, and resource allocation. This paper proposes a framework fo…
View article: Optimizing Hypertension Care Through Telementoring Education Platform in Jonglei State, South Sudan: A Framework of Extension of Community Healthcare Outcome-ECHO Project
Optimizing Hypertension Care Through Telementoring Education Platform in Jonglei State, South Sudan: A Framework of Extension of Community Healthcare Outcome-ECHO Project Open
South Sudan faces a critical public health crisis in managing hypertension, driven by a severe shortage of trained healthcare providers, inadequate infrastructure, and limited access to continuous medical education. With over 25% of the ad…
View article: Improving Sustainability of Pharmacy Level Digital Health Interventions in Africa
Improving Sustainability of Pharmacy Level Digital Health Interventions in Africa Open
Access to primary healthcare remains a critical challenge in Africa, particularly in underserved areas. This paper evaluates the mutti+ digital health (MDH) solution—a pharmacy-first model providing outpatient services through community ph…
View article: Regulating Innovation: Addressing the Challenges of Canada’s Health-Tech Sector
Regulating Innovation: Addressing the Challenges of Canada’s Health-Tech Sector Open
The Canadian health-tech sector faces regulatory challenges amidst rapid innovations in artificial intelligence (AI), digital health, biotechnology, and medical devices. This paper explores the regulatory landscape based on stakeholder int…
View article: Playing to Win in Healthcare: Framework for Developing Digital Health Strategy
Playing to Win in Healthcare: Framework for Developing Digital Health Strategy Open
Health information technology implementations frequently fail despite extensive research on success factors over the past three decades. This paper introduces the Playing-to-Win Digital Health Strategy Canvas, an adaptation of Martin and L…
View article: Advancing Patient-Centered Care in Ghana’s Community Pharmacies: A Digital Health Approach
Advancing Patient-Centered Care in Ghana’s Community Pharmacies: A Digital Health Approach Open
Community pharmacies in Ghana are essential healthcare access points but often focus only on dispensing medications, neglecting broader patient-centered care. This study identifies 21 key drivers of patient satisfaction through stakeholder…
View article: Achieving Interoperability in Primary Care in Canada: A Stakeholder Analysis Study
Achieving Interoperability in Primary Care in Canada: A Stakeholder Analysis Study Open
Canada’s healthcare system is undergoing rapid technological changes, alongside increasing demand for services, clinician burnout, and rising costs. Achieving interoperability between primary care electronic medical records (EMRs) is criti…
View article: Enablers of Patient Access to Healthcare Data: International Comparisons
Enablers of Patient Access to Healthcare Data: International Comparisons Open
Patient access to health records is increasingly recognized as a fundamental right to empower individuals and improve healthcare continuity. A comprehensive assessment tool was developed to evaluate dimensions of jurisdictional capacity, t…
View article: Personalized Multi-Domain Digital Platform for Dementia Prevention
Personalized Multi-Domain Digital Platform for Dementia Prevention Open
The Personalized Multi-Domain Digital Platform for Dementia Prevention (PM(DP)*2) is a conceptualized evidence-based initiative designed to reduce dementia burden through tailored interventions. By collecting and analyzing multidimensional…
View article: Multimodal Generative AI and Foundation Models for Behavioural Health in Online Gambling
Multimodal Generative AI and Foundation Models for Behavioural Health in Online Gambling Open
Online gambling platforms have transformed the gambling landscape, offering unprecedented accessibility and personalized experiences. However, these same characteristics have increased the risk of gambling-related harm, affecting individua…
View article: Knowledge is not all you need for comfort in use of AI in healthcare
Knowledge is not all you need for comfort in use of AI in healthcare Open
Our results underscore that increasing knowledge alone does not necessarily lead to greater comfort with AI in healthcare. Addressing public concerns through robust data governance, transparency, and inclusive AI design is essential to fos…
View article: Exploring Prediabetes Pathways Using Explainable AI on Data from Electronic Medical Records
Exploring Prediabetes Pathways Using Explainable AI on Data from Electronic Medical Records Open
This study leverages data from a Canadian database of primary care Electronic Medical Records to develop machine learning models predicting type 2 diabetes mellitus (T2D), prediabetes, or normoglycemia. These models are used as a basis for…
View article: A novel mathematical model for predicting the benefits of physical activity on type 2 diabetes progression
A novel mathematical model for predicting the benefits of physical activity on type 2 diabetes progression Open
Despite the well-acknowledged benefits of physical activity for type 2 diabetes (T2D) prevention, the literature surprisingly lacks validated models able to predict the long-term benefits of exercise on T2D progression and support personal…
View article: A Framework for Implementing Disease Prevention and Behavior Change Evidence at Scale
A Framework for Implementing Disease Prevention and Behavior Change Evidence at Scale Open
The current corpus of evidence-based information for chronic disease prevention and treatment is vast and growing rapidly. Behavior change theories are increasingly more powerful but difficult to operationalize in the current healthcare sy…
View article: Towards a Regulatory Framework for Electronic Medical Record Interoperability in Canada
Towards a Regulatory Framework for Electronic Medical Record Interoperability in Canada Open
All complex systems are potentially predisposed to failure. Healthcare systems are complex systems that are prone to many errors that can result in dire consequences for patients and healthcare providers. The healthcare system in Canada is…
View article: AI Can Improve the Economics of Blindness Prevention in Canada
AI Can Improve the Economics of Blindness Prevention in Canada Open
Diabetic retinopathy is a leading cause of vision loss in Canada and creates significant economic and social burden on patients. Diabetic retinopathy is largely a preventable complication of diabetes mellitus. Yet, hundreds of thousands of…
View article: Validation of a Design Architecture to Deliver Health Management and Behavior Change Evidence at Scale
Validation of a Design Architecture to Deliver Health Management and Behavior Change Evidence at Scale Open
Forty-four percent of Canadians over the age of 20 have a non-communicable disease (NCD). Millions of Canadians are at risk of developing the complications of NCDs; millions have already experienced those complications. Fortunately, the ev…
View article: Towards a Regulatory Framework for Electronic Medical Record Data Visualization
Towards a Regulatory Framework for Electronic Medical Record Data Visualization Open
Physicians struggle to retrieve data from electronic medical records. We evaluated a digital tool that enhances physician efficiency in retrieving and analyzing patient information for treatment decision-making. Our use case is the care of…
View article: Lack of Data Access, but Not Availability, Hinders AI Training for High-Risk Conditions in Ontario
Lack of Data Access, but Not Availability, Hinders AI Training for High-Risk Conditions in Ontario Open
Advanced disease prediction is an important step toward achieving a proactive healthcare system. New technologies such as artificial intelligence are very promising in their ability to predict the onset of future disease much earlier than …
View article: Towards a Unified Framework for Information and Interoperability Governance
Towards a Unified Framework for Information and Interoperability Governance Open
Challenges in health data interoperability have highlighted overall health care system inefficiencies. Many organizations struggle to establish a robust data governance infrastructure to meet the increasing demands of advanced data uses, l…
View article: Measuring and Managing Healthcare Supply and Demand in Real-Time
Measuring and Managing Healthcare Supply and Demand in Real-Time Open
Measuring the supply and demand for access to and wait-times for healthcare is key to managing healthcare services and allocating resources appropriately. Yet, few jurisdictions in distributed, socialized medicine settings have any way to …
View article: Towards a Regulatory Framework for Workflow Improvement in Electronic Medical Records
Towards a Regulatory Framework for Workflow Improvement in Electronic Medical Records Open
Physicians have to complete several time-consuming and burnout-inducing tasks in their EMRs for everyday care of patients. Poor workflow design generates increased effort for physicians. In this study, we measure time doctors take to retri…