Karima F. Mahrous
YOU?
Author Swipe
View article: Clinical signs, morphological and phylogenetic characterization of Myxozoan spp. infecting Nile tilapia, Oreochromis niloticus and African catfish, Clarias gariepinus in Qalyubia Governorate, Egypt
Clinical signs, morphological and phylogenetic characterization of Myxozoan spp. infecting Nile tilapia, Oreochromis niloticus and African catfish, Clarias gariepinus in Qalyubia Governorate, Egypt Open
View article: Synthesis, bioactivity assessment, molecular docking and ADMET studies of new chromone congeners exhibiting potent anticancer activity
Synthesis, bioactivity assessment, molecular docking and ADMET studies of new chromone congeners exhibiting potent anticancer activity Open
View article: Molecular characterization of Glugea anomala infecting Nile tilapia, Oreochromis niloticus and African Catfish, Clarias gariepinus and its associated pathological changes
Molecular characterization of Glugea anomala infecting Nile tilapia, Oreochromis niloticus and African Catfish, Clarias gariepinus and its associated pathological changes Open
The present study aimed to molecularly diagnose microsporidia in Nile tilapia and African catfish at the Qalyubia Governorate in Egypt and describe the histopathological alterations that are related with them. Seventy-nine out of 400 (19.7…
View article: Coculture of bacterial levans and evaluation of its anti-cancer activity against hepatocellular carcinoma cell lines
Coculture of bacterial levans and evaluation of its anti-cancer activity against hepatocellular carcinoma cell lines Open
View article: Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR
Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR Open
Four pyrazol derivatives (4, 5, 7, and 25) showed potent anti-PACA-2 cell line with IC 50 (13.0, 31.5 and 24.9, 5.5 μg mL −1 ) respectively, while compounds 23 and 25 showed potent anti-PC3 cell line with IC 50 (26.1 and 11.8 μg mL −1 ).
View article: Genetic diversity, Population Structure and their Association with Body Weight in Egyptian Chicken Strains
Genetic diversity, Population Structure and their Association with Body Weight in Egyptian Chicken Strains Open
A Genetic characteristics and population structure within and among Egyptian indigenous chicken strains are important for identifying some genetic resources. The present study aimed to use microsatellite markers to determine similarity and…
View article: A Simple and New Chromone Congeners Promote Anticancer Activity: Synthesis, Bioactivity Assessment and molecular docking study with ADME profile
A Simple and New Chromone Congeners Promote Anticancer Activity: Synthesis, Bioactivity Assessment and molecular docking study with ADME profile Open
In consideration of the chromones' therapeutic potential and anticancer activity, a new series of chromanone derivatives have been synthesized through a straightforward reaction between 6-formyl-7-hydroxy-5-methoxy-2-methylchromone ( 2 ) a…
View article: Impact of trifluoromethyl and sulfonyl groups on the biological activity of novel aryl-urea derivatives: synthesis, in-vitro, in-silico and SAR studies
Impact of trifluoromethyl and sulfonyl groups on the biological activity of novel aryl-urea derivatives: synthesis, in-vitro, in-silico and SAR studies Open
View article: Design, synthesis, in vitro anticancer, molecular docking and SAR studies of new series of pyrrolo[2,3-d]pyrimidine derivatives
Design, synthesis, in vitro anticancer, molecular docking and SAR studies of new series of pyrrolo[2,3-d]pyrimidine derivatives Open
View article: In silico and in vitro studies of novel cyanoacrylamides incorporating pyrazole moiety against breast and prostate carcinomas
In silico and in vitro studies of novel cyanoacrylamides incorporating pyrazole moiety against breast and prostate carcinomas Open
We report novel cyanoacrylamide derivatives bearing the pyrazole moiety. The molecular structures of the prepared cyanoacrylamides were confirmed by the different spectral tools such as NMR, IR, and elemental analyses. The anticancer effec…
View article: Biochemical and histopathological studies of sulfonylurea derivative as a new chemotherapeutic agent against liver cancer in free- and nano-coated forms
Biochemical and histopathological studies of sulfonylurea derivative as a new chemotherapeutic agent against liver cancer in free- and nano-coated forms Open
The most frequent type of primary liver cancer is hepatocellular carcinoma (HCC), accounting for approximately 90% of primary liver cancers and a third leading cause of cancer deaths. In the current study, the synthesized compound 3 was re…
View article: Inhibition of induced-hepatic cancer in vivo through IQGAP1-shRNA gene therapy and modulation of TRAIL-induced apoptosis pathway
Inhibition of induced-hepatic cancer in vivo through IQGAP1-shRNA gene therapy and modulation of TRAIL-induced apoptosis pathway Open
Background Liver cancer is the deadliest malignancy among common tumors. It is the top cause of cancer-related deaths in Egypt, and it is characterized by increasing occurrence among the population. The objective of this study was to deter…
View article: Genetic structure of some candidate genes of repeat breeder syndrome in Egyptian buffaloes
Genetic structure of some candidate genes of repeat breeder syndrome in Egyptian buffaloes Open
View article: Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT166 as a Surrogate Model Colorectal Carcinoma
Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT166 as a Surrogate Model Colorectal Carcinoma Open
The IQGAP1 regulates the expression of IQGAPs, Ras, IL-8 receptors, and the apoptotic network. Therefore, the silence of IQGAP1 is a promising strategy for colon cancer therapy.
View article: Correction to: Zinc Oxide Nanoparticles Boost the Immune Responses in Oreochromis niloticus and Improve Disease Resistance to Aeromonas hydrophila Infection
Correction to: Zinc Oxide Nanoparticles Boost the Immune Responses in Oreochromis niloticus and Improve Disease Resistance to Aeromonas hydrophila Infection Open
View article: Genetic polymorphism of the growth hormone (GH5) gene in small ruminants
Genetic polymorphism of the growth hormone (GH5) gene in small ruminants Open
The present study was conducted to detect polymorphism of growth hormone (GH5) gene in different ovine and caprine breeds.A 468 bp fragment of growth hormone gene spanning over 5'UTR, exon1, intron1 and partial of exon 2 were amplified and…
View article: Effect of Diet Restriction and Polymorphism of Bone Morphogenetic Protein-15 and Growth Differentiation Factor-9 (GDF9) on Reproductive Performance of Three Egyptian Fat Tail Sheep Breeds
Effect of Diet Restriction and Polymorphism of Bone Morphogenetic Protein-15 and Growth Differentiation Factor-9 (GDF9) on Reproductive Performance of Three Egyptian Fat Tail Sheep Breeds Open
Several genes are controlling prolificay of sheep. The bone morphogenetic protein-15 and growth differentiation factor-9 (GDF9) are control reproductivity of sheep. This study aimed to eplore diet restriction and the polymorphism in the bo…
View article: Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies
Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies Open
Twelve novel chalcone derivatives were prepared using the Claisen–Schmidt condensation reaction. The reaction of 4‐acetyl‐5‐furan/thiophene‐pyrazole derivatives 5 with the corresponding aldehydes 6 afforded the targeted chalcone derivative…
View article: CCDC 1896796: Experimental Crystal Structure Determination
CCDC 1896796: Experimental Crystal Structure Determination Open
View article: Genetic variations in the Myostatin gene affecting growth traits in sheep
Genetic variations in the Myostatin gene affecting growth traits in sheep Open
Background and Aim: Sheep productivity in developing countries is crucial, as this animal is an essential source of meat and wool. Myostatin (MSTN) plays an important role in the regulation of muscle mass through the regulation of muscle g…
View article: Screening of IGF-I and IGFBP-3 genes polymorphism in popular Goat breeds in Egypt
Screening of IGF-I and IGFBP-3 genes polymorphism in popular Goat breeds in Egypt Open
The genetic polymorphisms of two functional genes; Insulin-like growth-I (IGF-I) and Insulin-like growth factor binding protein-3 (IGFBP-3) were investigated in three goat breeds (Barki, Damascus and Zaraibi) by polymerase chain reaction (…
View article: Identification of candidate genes associated with milk yield trait in buffaloes ( Bubalus bubalis ) by restriction-site-associated DNA sequencing
Identification of candidate genes associated with milk yield trait in buffaloes ( Bubalus bubalis ) by restriction-site-associated DNA sequencing Open
The objectives of our present study included the screening of single nucleotide polymorphisms (SNP) that show significant differences in allelic frequencies between two buffalo populations (Egyptian and Chinese buffaloes), categorization o…
View article: Polymorphism of the Prolactin Gene in Egyptian Duck Breeds
Polymorphism of the Prolactin Gene in Egyptian Duck Breeds Open
In avian, the prolactin hormone triggers and regulates ovarian follicle development.This study aims to detect the Prolactin (PRL) gene polymorphisms (exons 1and5) in four Egyptian duck breeds, namely Campbell, Moulard, Muscovy, and Pekin u…
View article: Correction to: Molecular characterization and expression analysis of hepc1 and hepc2 in three tilapia species collected from Lake Manzala
Correction to: Molecular characterization and expression analysis of hepc1 and hepc2 in three tilapia species collected from Lake Manzala Open
After publication of the original article [1], we were notified that Figure 1 is incorrect. The corresponding author uploaded the wrong figure by mistake.
View article: Molecular characterization and expression analysis of hepc1 and hepc2 in three tilapia species collected from Lake Manzala
Molecular characterization and expression analysis of hepc1 and hepc2 in three tilapia species collected from Lake Manzala Open
Background Antimicrobial peptides were examined as an evolutionarily preserved component of the innate immune response and identified as a vital first-line defense against a broad spectrum of pathogens in fish. The objective of this study …
View article: Detection of polymorphism within leptin gene in Egyptian river buffalo and predict its effects on different molecular levels
Detection of polymorphism within leptin gene in Egyptian river buffalo and predict its effects on different molecular levels Open
Four SNPs were revealed among the tested animals. Twenty-one SNPs were found between the sequenced amplicon and the buffalo records in the Genbank. Some SNPs were predicted to have several effects on different biological processes like mRN…
View article: Identification of candidate genes associated with milk yield trait in buffaloes ( Bubalus bubalis ) by restriction-site-associated DNA sequencing
Identification of candidate genes associated with milk yield trait in buffaloes ( Bubalus bubalis ) by restriction-site-associated DNA sequencing Open
The objectives of our present study included the screening of single nucleotide polymorphisms (SNP) that show significant differences in allelic frequencies between two buffalo populations (Egyptian and Chinese buffaloes), categorization o…
View article: Single nucleotide polymorphisms in the growth hormone receptor gene and Alu1 polymorphisms in the diacylglycerol acyltransferase 1 gene as related to meat production in sheep
Single nucleotide polymorphisms in the growth hormone receptor gene and Alu1 polymorphisms in the diacylglycerol acyltransferase 1 gene as related to meat production in sheep Open
Aim: This study aimed to investigate the polymorphisms in genes related to meat production, including growth hormone receptor (GHR) and diacylglycerol acyltransferase 1 (DGAT1) genes, in different breeds of sheep, including Barki, Najdi, a…
View article: Single-nucleotide polymorphisms in FABP4 gene associated with growth traits in Egyptian sheep
Single-nucleotide polymorphisms in FABP4 gene associated with growth traits in Egyptian sheep Open
Aim: The present study was performed to assess the association of single-nucleotide polymorphisms (SNPs) in the fatty acid-binding protein 4 (FABP4) gene with birth weight (BW), final weight (FW), and average daily gain (ADG) in three Egyp…
View article: Polymorphism of growth hormone gene in three goat breeds in Egypt
Polymorphism of growth hormone gene in three goat breeds in Egypt Open