Karin Bergmark
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View article: The effect of tinzaparin on biomarkers in FIGO stages III-IV ovarian cancer patients undergoing neoadjuvant chemotherapy – the TABANETOC trial: study protocol for a randomized clinical multicenter trial
The effect of tinzaparin on biomarkers in FIGO stages III-IV ovarian cancer patients undergoing neoadjuvant chemotherapy – the TABANETOC trial: study protocol for a randomized clinical multicenter trial Open
Background: Tinzaparin, a low-molecular weight heparin (LMWH), has shown anti-neoplastic properties in animal models and in in vitro studies of human cancer cell lines. The reduction of CA-125 levels during neoadjuvant chemotherapy (NACT) …
View article: Remarkable effects of infliximab on severe radiation-induced side effects in a patient with uterine cervical cancer: a case report
Remarkable effects of infliximab on severe radiation-induced side effects in a patient with uterine cervical cancer: a case report Open
Pelvic radiotherapy is a powerful treatment for a broad range of cancers, including gynecological, prostate, rectal, and anal cancers. Despite improvements in the delivery of ionizing beams, damage to non-cancerous tissue can cause long-te…
View article: Intra-abdominal Surgery and Intestinal Syndromes After Pelvic Radiation Therapy
Intra-abdominal Surgery and Intestinal Syndromes After Pelvic Radiation Therapy Open
We found intra-abdominal surgery to be a risk factor among survivors of gynecologic cancer, increasing the intensity score of 4 out of 5 radiation-induced intestinal syndromes. During radiation therapy, it may be worthwhile to pay extra at…
View article: Astatine-211 based radionuclide therapy: Current clinical trial landscape
Astatine-211 based radionuclide therapy: Current clinical trial landscape Open
Astatine-211 ( 211 At) has physical properties that make it one of the top candidates for use as a radiation source for alpha particle-based radionuclide therapy, also referred to as targeted alpha therapy (TAT). Here, we summarize the mai…
View article: Sexual health and wellbeing among female pelvic cancer survivors following individualized interventions in a nurse-led clinic
Sexual health and wellbeing among female pelvic cancer survivors following individualized interventions in a nurse-led clinic Open
Purpose Treatment-induced sexual and intestinal dysfunctions coexist among women after pelvic radiotherapy. We aimed to explore if sexual health and wellbeing may be improved after radiotherapy following nurse-led interventions and if an a…
View article: A Preparatory Study for a Randomized Controlled Trial of Dietary Fiber Intake During Adult Pelvic Radiotherapy
A Preparatory Study for a Randomized Controlled Trial of Dietary Fiber Intake During Adult Pelvic Radiotherapy Open
Background: Patients undergoing pelvic radiotherapy are often advised to omit fiber-rich foods from their diet to reduce the adverse effects of treatment. Scientific evidence supporting this recommendation is lacking, and recent studies on…
View article: Cohort profile: an observational longitudinal data collection of health aspects in a cohort of female cancer survivors with a history of pelvic radiotherapy—a population-based cohort in the western region of Sweden
Cohort profile: an observational longitudinal data collection of health aspects in a cohort of female cancer survivors with a history of pelvic radiotherapy—a population-based cohort in the western region of Sweden Open
Purpose The study ‘Health among women after pelvic radiotherapy’ was conducted in response to the need for more advanced and longitudinal data concerning long-term radiotherapy-induced late effects and chronic states among female cancer su…
View article: Dose-response relationships of intestinal organs and excessive mucus discharge after gynaecological radiotherapy
Dose-response relationships of intestinal organs and excessive mucus discharge after gynaecological radiotherapy Open
Background The study aims to determine possible dose-volume response relationships between the rectum, sigmoid colon and small intestine and the ‘excessive mucus discharge’ syndrome after pelvic radiotherapy for gynaecological cancer. Meth…
View article: Sex steroid hormone receptor expression in the vaginal wall in cervical cancer survivors after radiotherapy
Sex steroid hormone receptor expression in the vaginal wall in cervical cancer survivors after radiotherapy Open
Background: Sex steroid hormones and their receptors are important in female sexual function. The aim of this study was to investigate the expression and distribution of estrogen receptor (ER)α, ERβ, G-protein-coupled ER-1 (GPER), androgen…
View article: Intraperitoneal α-Emitting Radioimmunotherapy with<sup>211</sup>At in Relapsed Ovarian Cancer: Long-Term Follow-up with Individual Absorbed Dose Estimations
Intraperitoneal α-Emitting Radioimmunotherapy with<sup>211</sup>At in Relapsed Ovarian Cancer: Long-Term Follow-up with Individual Absorbed Dose Estimations Open
Eliminating microscopic residual disease with α-particle radiation is theoretically appealing. After extensive preclinical work with α-particle-emitting 211At, we performed a phase I trial with intraperitoneal α-particle therapy in epithel…
View article: Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors
Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors Open
In this observational study, we found an association between a high intake of citrus fruits and vegetables and a lower intensity of the studied radiation-induced cancer survivorship syndromes. Our data suggest it may be worthwhile to conti…
View article: Dose-response relationships of the sigmoid for urgency syndrome after gynecological radiotherapy
Dose-response relationships of the sigmoid for urgency syndrome after gynecological radiotherapy Open
Primarily the dose to sigmoid colon as well as the rectum is related to urgency syndrome among gynecological cancer survivors. Separate delineation of the rectum and sigmoid colon in order to incorporate the dose-response results may aid i…
View article: Dose-response relationships of the sigmoid for urgency syndrome after gynecological radiotherapy
Dose-response relationships of the sigmoid for urgency syndrome after gynecological radiotherapy Open
Purpose: To find out what organs and doses are most relevant for ‘radiation-induced urgency syndrome’ in order to derive the corresponding dose–response relationships as an aid for avoiding the syndrome in the future. Material and methods:…
View article: Radiotherapy for cervical cancer – impact on the vaginal epithelium and sexual function
Radiotherapy for cervical cancer – impact on the vaginal epithelium and sexual function Open
We found that cervical cancer treatment including radiotherapy is associated with vaginal epithelial atrophy and sexual dysfunction. To hamper the atrophic process affecting the sexual function, an early start of local estrogen after thera…
View article: Radiation physiology – evidence for a higher biological effect of 24 Gy in four fractions as compared to three
Radiation physiology – evidence for a higher biological effect of 24 Gy in four fractions as compared to three Open
For the first time in history, curing cancer with radiotherapy and restoring health in the cancer survivor seem to be realistic goals for tumors in the pelvic cavity. The risk of radiation-induced ...
View article: Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment – gynecological cancer survivors
Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment – gynecological cancer survivors Open
Smoking aggravates the radiation-induced urgency syndrome and excessive gas discharge syndrome. Smoking cessation may promote bowel health among gynecological-cancer survivors. Furthermore, by understanding the mechanism for the decline in…
View article: Identifying radiation-induced survivorship syndromes affecting bowel health in a cohort of gynecological cancer survivors
Identifying radiation-induced survivorship syndromes affecting bowel health in a cohort of gynecological cancer survivors Open
Late effects of radiotherapy include five syndromes affecting bowel health; studying them and identifying the underlying survivorship diseases, instead of the approximately 30 long-term symptoms they produce, will simplify the search for p…
View article: Radiotherapy-induced vaginal fibrosis in cervical cancer survivors
Radiotherapy-induced vaginal fibrosis in cervical cancer survivors Open
We found drastic differences in the vaginal wall between the irradiated cervical cancer survivors and the controls, indicating that radiotherapy-induced vaginal symptoms are mediated by connective tissue fibrosis and elastosis. Our results…
View article: Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment – gynecological cancer survivors
Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment – gynecological cancer survivors Open
Background: It is unknown whether smoking; age at time of radiotherapy or time since radiotherapy influence the intensity of late radiation-induced bowel syndromes. Material and methods: We have previously identified 28 symptoms decreasing…