Karin D. Prummel
YOU?
Author Swipe
View article: SpliceUp: Predicting <i>SF3B1</i> mutations in individual cells via aberrant splice site activation from scRNA-seq data
SpliceUp: Predicting <i>SF3B1</i> mutations in individual cells via aberrant splice site activation from scRNA-seq data Open
Myeloid neoplasms (MN) are clonal heterogeneous disorders initiated by somatic driver mutations in hematopoietic stem and progenitor cells (HSPCs). Among the most common are mutations in RNA splicing factors, which exert pleiotropic effect…
View article: Dual role of ZIC2 during neural induction: from pioneer transcription factor to enhancer activator
Dual role of ZIC2 during neural induction: from pioneer transcription factor to enhancer activator Open
ZIC2, a member of the Zinc Finger of the Cerebellum family of transcription factors (TFs), plays crucial roles during neural development. In humans, defects in ZIC2 cause holoprosencephaly, a congenital brain malformation characterized by …
View article: Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics
Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics Open
View article: Co-option of neck muscles supported the vertebrate water-to-land transition
Co-option of neck muscles supported the vertebrate water-to-land transition Open
View article: Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS
Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS Open
Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP), potentially progressing to myelodysplastic syndromes (MDS). Here, we investigated how CHIP and MDS remodel…
View article: CO-OPTION OF NECK MUSCLES SUPPORTED THE VERTEBRATE WATER-TO-LAND TRANSITION
CO-OPTION OF NECK MUSCLES SUPPORTED THE VERTEBRATE WATER-TO-LAND TRANSITION Open
A major event in vertebrate evolution was the separation of the skull from the pectoral girdle and the acquisition of a functional neck, transitions which required profound developmental rearrangements of the musculoskeletal system. The ne…
View article: Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune disease
Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune disease Open
Enhancers and transcription factors (TFs) are crucial in regulating cellular processes, including disease-associated cell states. Current multiomic technologies to study these elements in gene regulatory mechanisms lack multiplexing capabi…
View article: A median fin derived from the lateral plate mesoderm and the origin of paired fins
A median fin derived from the lateral plate mesoderm and the origin of paired fins Open
The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial transition of vertebrates. Largely derived from the lateral plate mesoderm (LPM), one hypothesis for the evolution of pai…
View article: Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2
Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2 Open
Endothelial specification is a key event during embryogenesis; however, when, and how, endothelial cells separate from other lineages is poorly understood. In zebrafish, Npas4l is indispensable for endothelial specification by inducing the…
View article: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma Open
View article: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma Open
The mesothelium forms epithelial membranes that line the bodies cavities and surround the internal organs. Mesothelia widely contribute to organ homeostasis and regeneration, and their dysregulation can result in congenital anomalies of th…
View article: Supplementary code: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Supplementary code: Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma Open
This repository contains all code necessary to reproduce all analyses and figures from our above-mentioned manuscript. A browesable workflowr website of the analysis can be viewed HERE.
View article: The lateral plate mesoderm
The lateral plate mesoderm Open
The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite this central role in deve…
View article: A conserved regulatory program initiates lateral plate mesoderm emergence across chordates
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates Open
View article: A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates
A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates Open
View article: Mutations in <i>Bcl9</i> and <i>Pygo</i> genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling
Mutations in <i>Bcl9</i> and <i>Pygo</i> genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling Open
Bcl9 and Pygopus (Pygo) are obligate Wnt/β-catenin cofactors in Drosophila , yet their contribution to Wnt signaling during vertebrate development remains unresolved. Combining zebrafish and mouse genetics, we document a conserved, β-caten…
View article: Continuous addition of progenitors forms the cardiac ventricle in zebrafish
Continuous addition of progenitors forms the cardiac ventricle in zebrafish Open
View article: A conserved regulatory program drives emergence of the lateral plate mesoderm
A conserved regulatory program drives emergence of the lateral plate mesoderm Open
Cardiovascular lineages develop together with kidney, smooth muscle, and limb connective tissue progenitors from the lateral plate mesoderm (LPM). How the LPM initially emerges and how its downstream fates are molecularly interconnected re…
View article: Continuous addition of progenitors forms the cardiac ventricle in zebrafish
Continuous addition of progenitors forms the cardiac ventricle in zebrafish Open
The vertebrate heart develops from several progenitor lineages. After early-differentiating first heart field (FHF) progenitors form the linear heart tube, late-differentiating second heart field (SHF) progenitors extend atrium, ventricle,…
View article: Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells Open