Karin F. Hoth
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View article: Long COVID: lung pathophysiology and its relationship with cognitive dysfunction
Long COVID: lung pathophysiology and its relationship with cognitive dysfunction Open
Post-acute sequelae of COVID-19 (Long COVID) includes physical and cognitive symptoms that can last long after acute infection. Links between lung pathophysiology and cognitive dysfunction in Long COVID remain largely unexplored. Long COVI…
View article: Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19
Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19 Open
Importance Given the increased vulnerability to COVID-19 among those with a serious mental illness (SMI), it remains unclear whether these individuals face a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC). Understanding …
View article: Efficacy of Diet on Quality of life in Multiple Sclerosis (EDQ-MS): a study protocol for a randomized controlled clinical trial
Efficacy of Diet on Quality of life in Multiple Sclerosis (EDQ-MS): a study protocol for a randomized controlled clinical trial Open
Background The primary objective of this study is to evaluate the efficacy of two dietary interventions, time-restricted olive oil-based (TROO) ketogenic and modified Paleolithic elimination (MPE), compared to usual care control group rece…
View article: Frequency of cannabis use and symptoms of anxiety and depression: a cross-sectional analysis of the Colorado cannabis users health cohort
Frequency of cannabis use and symptoms of anxiety and depression: a cross-sectional analysis of the Colorado cannabis users health cohort Open
Background Cannabis is commonly used as a self-prescribed treatment for anxiety and depression, but few studies have evaluated these associations using both validated mental health scales and biological cannabinoid markers. This study aime…
View article: Long COVID: Lung Pathophysiology and its Relationship with Cognitive Dysfunction
Long COVID: Lung Pathophysiology and its Relationship with Cognitive Dysfunction Open
View article: Whole-genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia
Whole-genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia Open
In studies of individuals of primarily European genetic ancestry, common and low-frequency variants and rare coding variants have been found to be associated with the risk of bipolar disorder (BD) and schizophrenia (SZ). However, less is k…
View article: Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort
Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort Open
Frailty is associated with respiratory exacerbations and mortality in individuals with Chronic Obstructive Pulmonary Disease (COPD). Among those with a smoking history and normal spirometry, frailty's association with respiratory outcomes …
View article: 0344 Association Between Sleep Regularity and Cognitive Function in Older Adults
0344 Association Between Sleep Regularity and Cognitive Function in Older Adults Open
Introduction Sleep changes are common as people age, with nearly 50% of older adults experiencing sleep-related difficulties. Poor sleep quality negatively impacts cognition; however, much of the existing research has relied on self-report…
View article: Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia
Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia Open
In studies of individuals of primarily European genetic ancestry, common and low-frequency variants and rare coding variants have been found to be associated with the risk of bipolar disorder (BD) and schizophrenia (SZ). However, less is k…
View article: Symptoms 6 Weeks After COVID-19 are Reduced Among US Healthcare Personnel Receiving Additional Vaccine Doses during the Omicron Period, December 2021–April 2022
Symptoms 6 Weeks After COVID-19 are Reduced Among US Healthcare Personnel Receiving Additional Vaccine Doses during the Omicron Period, December 2021–April 2022 Open
Background The objective of this study was to test the hypothesis that subsequent doses of the COVID-19 vaccine are associated with lower incidence of COVID-19-like symptoms at 6 weeks after infection. Methods This study was a case-control…
View article: Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial
Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial Open
Chronic kidney disease (CKD) increases the risk of cardiovascular disease and cognitive impairment. Curcumin is a polyphenol that improves vascular and cognitive function in older adults; however, its effects on vascular and cognitive func…
View article: Efficacy of Diet on Quality of Life in Adults With Multiple Sclerosis (EDQ-MS): Study Protocol for A Randomized Controlled Clinical Trial
Efficacy of Diet on Quality of Life in Adults With Multiple Sclerosis (EDQ-MS): Study Protocol for A Randomized Controlled Clinical Trial Open
View article: Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex
Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex Open
Depression is heritable, differs by sex, and has environmental risk factors such as cigarette smoking. However, the effect of single nucleotide polymorphisms (SNPs) on depression through cigarette smoking and the role of sex is unclear. In…
View article: Availability and use of institutional support programs for emergency department healthcare personnel during the COVID-19 pandemic
Availability and use of institutional support programs for emergency department healthcare personnel during the COVID-19 pandemic Open
Objectives The COVID-19 pandemic placed health care personnel (HCP) at risk for stress, anxiety, burnout, and post-traumatic stress disorder (PTSD). To address this, hospitals developed programs to mitigate risk. The objectives of the curr…
View article: Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study
Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study Open
clinicaltrials.gov identifier: NCT04009005.
View article: 24 hour rest‐activity rhythms and cognition in community dwelling older adults
24 hour rest‐activity rhythms and cognition in community dwelling older adults Open
Background Cognitive decline associated with aging is a growing public health concern as individuals are living longer with chronic medical conditions. Rest activity rhythm (RAR) describes the pattern of physical activity and sleep period …
View article: Hippocampal Volume and Circadian Rhythm Characteristics
Hippocampal Volume and Circadian Rhythm Characteristics Open
Background Hippocampal atrophy is one of the prominent neurodegenerative features of Alzheimer’s disease and related dementias. Alterations in circadian rhythms and 24‐hour rest activity rhythms can exacerbate cognitive aging and neurodege…
View article: MEDIATING ROLE OF REST–ACTIVITY RHYTHM ON THE RELATIONSHIP BETWEEN DEPRESSIVE SYMPTOM AND COGNITION IN OLDER ADULTS
MEDIATING ROLE OF REST–ACTIVITY RHYTHM ON THE RELATIONSHIP BETWEEN DEPRESSIVE SYMPTOM AND COGNITION IN OLDER ADULTS Open
Depressive symptoms and cognitive impairments are common problems in older adults. Rest-Activity Rhythm (RAR) encompasses sleep, physical activity, and rest in 24 hours. Often, individuals with depressive symptoms present altered RAR. The …
View article: Factors associated with the decision to receive bivalent COVID-19 booster vaccination among health care personnel
Factors associated with the decision to receive bivalent COVID-19 booster vaccination among health care personnel Open
COVID-19 vaccination is effective at reducing SARS-CoV-2 complications, but uptake has been low. Our objective in this study was to compare the importance of factors reported to influence the decision to receive a bivalent COVID-19 booster…
View article: Circadian timing, melatonin and hippocampal volume in later‐life adults
Circadian timing, melatonin and hippocampal volume in later‐life adults Open
Summary Hippocampal atrophy is a prominent neurodegenerative feature of Alzheimer's disease and related dementias. Alterations in circadian rhythms can exacerbate cognitive aging and neurodegeneration. This study aimed to examine how dim l…
View article: Diet-induced changes in functional disability are mediated by fatigue in relapsing-remitting multiple sclerosis: A secondary analysis of the WAVES randomized parallel-arm trial
Diet-induced changes in functional disability are mediated by fatigue in relapsing-remitting multiple sclerosis: A secondary analysis of the WAVES randomized parallel-arm trial Open
Background People with multiple sclerosis (MS) often report dietary modifications; however, evidence on functional outcomes remains sparse. Objective Evaluate the impact of the low-saturated fat (Swank) and modified Paleolithic elimination…
View article: Association Between Improved Serum Fatty Acid Profiles and Cognitive Function During a Dietary Intervention Trial in Relapsing-Remitting Multiple Sclerosis
Association Between Improved Serum Fatty Acid Profiles and Cognitive Function During a Dietary Intervention Trial in Relapsing-Remitting Multiple Sclerosis Open
BACKGROUND: Cognitive impairment is a common multiple sclerosis (MS)-related symptom that impacts quality of life (QOL). Diet interventions are shown to be beneficial in managing QOL, and the intake of essential fatty acids is linked with …
View article: Early Evidence of Chronic Obstructive Pulmonary Disease Obscured by Race-Specific Prediction Equations
Early Evidence of Chronic Obstructive Pulmonary Disease Obscured by Race-Specific Prediction Equations Open
Rationale: The identification of early chronic obstructive pulmonary disease (COPD) is essential to appropriately counsel patients regarding smoking cessation, provide symptomatic treatment, and eventually develop disease-modifying …
View article: Longitudinal association between multimorbidity, cognitive decline and neuropsychiatric symptoms
Longitudinal association between multimorbidity, cognitive decline and neuropsychiatric symptoms Open
Background Alzheimer’s disease (AD) is the most common form of dementia afflicting more than 5.8 million older adults in the United States. In AD, cognitive decline and neuropsychiatric symptoms are more pronounced in those who have chroni…
View article: Association of serum homocysteine, folate, and vitamin B12 and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial
Association of serum homocysteine, folate, and vitamin B12 and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial Open
View article: Use of the Spirometric “Fixed-Ratio” Underdiagnoses COPD in African-Americans in a Longitudinal Cohort Study
Use of the Spirometric “Fixed-Ratio” Underdiagnoses COPD in African-Americans in a Longitudinal Cohort Study Open
View article: Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function
Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function Open
Higher mtDNA CN in blood is associated with better current and future general cognitive function in large and diverse communities across the United States. Although MR analyses did not support a causal role, additional research is needed t…
View article: Cognitive function and inhaler technique following recovery from exacerbations of COPD
Cognitive function and inhaler technique following recovery from exacerbations of COPD Open
Cognitive impairment is highly prevalent in COPD outpatients during the post-exacerbation recovery period and is associated with poor inhaler technique https://bit.ly/3XkCvCv.
View article: Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study
Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study Open
Objectives Although COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in …
View article: Prevalence of abnormal spirometry in individuals with a smoking history and no known obstructive lung disease
Prevalence of abnormal spirometry in individuals with a smoking history and no known obstructive lung disease Open