Karin Giller
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View article: Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation
Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation Open
Alzheimer’s disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ)…
View article: The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions
The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions Open
Physiologically relevant in vitro models of amyloid aggregation are essential for linking structural insights to disease pathology. In type 2 diabetes, aggregation of human islet amyloid polypeptide (hIAPP) into fibrils is a hallmark of β-…
View article: The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation.
The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation. Open
Alzheimer’s disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ)…
View article: The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation
The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation Open
Alzheimer’s disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ)…
View article: Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)
Cryo-EM structures of lipidic fibrils of amyloid-β (1-40) Open
Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disease characterized by the extracellular deposition of amyloid plaques. Investigation into the composition of these plaques revealed a high amount of amyloid-β (Aβ…
View article: Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)
Cryo-EM structures of lipidic fibrils of amyloid-β (1-40) Open
Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disease characterized by the extracellular deposition of amyloid plaques. Investigation into the composition of these plaques revealed a high amount of amyloid-β (Aβ…
View article: Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR
Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR Open
Small molecules that bind to oligomeric protein species such as membrane proteins and fibrils are of clinical interest for development of therapeutics and diagnostics. Definition of the binding site at atomic resolution via NMR is often ch…
View article: Mechanism of sensor kinase CitA transmembrane signaling
Mechanism of sensor kinase CitA transmembrane signaling Open
Membrane bound histidine kinases (HKs) are ubiquitous sensors of extracellular stimuli in bacteria. Here, we used solid-state NMR in conjunction with crystallography, solution NMR and distance measurements to investigate the transmembrane …
View article: Familial Alzheimer’s Disease-Related Mutations Differentially Alter Stability of Amyloid-Beta Aggregates
Familial Alzheimer’s Disease-Related Mutations Differentially Alter Stability of Amyloid-Beta Aggregates Open
Amyloid-beta (Aβ) deposition as senile plaques is a pathological hallmark of Alzheimer's disease (AD). AD is characterized by a large level of heterogeneity in amyloid pathology, whose molecular origin is poorly understood. Here, we employ…
View article: Maturation of amyloid β fibrils alters their molecular stability
Maturation of amyloid β fibrils alters their molecular stability Open
High-pressure NMR investigation of freshly prepared and aged amyloid-beta aggregates reveals that their stability against pressure-induced monomer dissociation is increased through maturation.
View article: Structure and Gating Behavior of the Human Integral Membrane Protein VDAC1 in a Lipid Bilayer
Structure and Gating Behavior of the Human Integral Membrane Protein VDAC1 in a Lipid Bilayer Open
The voltage-dependent anion channel (VDAC), the most abundant protein in the outer mitochondrial membrane, is responsible for the transport of all ions and metabolites into and out of mitochondria. Larger than any of the β-barrel structure…
View article: Author Correction: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro
Author Correction: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro Open
Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2.Corrected Title: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro.
View article: Proton Detected Solid-State NMR of Membrane Proteins at 28 Tesla (1.2 GHz) and 100 kHz Magic-Angle Spinning
Proton Detected Solid-State NMR of Membrane Proteins at 28 Tesla (1.2 GHz) and 100 kHz Magic-Angle Spinning Open
The available magnetic field strength for high resolution NMR in persistent superconducting magnets has recently improved from 23.5 to 28 Tesla, increasing the proton resonance frequency from 1 to 1.2 GHz. For magic-angle spinning (MAS) NM…
View article: Membrane-embedded TSPO: an NMR view
Membrane-embedded TSPO: an NMR view Open
Translocator Protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein commonly used as a biomarker for neuroinflammation and is also a potential therapeutic target in neurodegenerative diseases. Despite intensive research efforts, …
View article: Protein resonance assignment by BSH‐CP‐based 3D solid‐state NMR experiments: A practical guide
Protein resonance assignment by BSH‐CP‐based 3D solid‐state NMR experiments: A practical guide Open
Solid‐state NMR (ssNMR) spectroscopy has evolved into a powerful method to obtain structural information and to study the dynamics of proteins at atomic resolution and under physiological conditions. The method is especially well suited to…
View article: Probing Membrane Protein Insertion into Lipid Bilayers by Solid‐State NMR
Probing Membrane Protein Insertion into Lipid Bilayers by Solid‐State NMR Open
Determination of the environment surrounding a protein is often key to understanding its function and can also be used to infer the structural properties of the protein. By using proton‐detected solid‐state NMR, we show that reduced spin d…