Karin Hellgren
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View article: Nationwide temporal trends in adverse pregnancy outcomes and treatments in systemic lupus erythematosus pregnancy over two decades in Sweden
Nationwide temporal trends in adverse pregnancy outcomes and treatments in systemic lupus erythematosus pregnancy over two decades in Sweden Open
Objective This nationwide descriptive study examined temporal trends in adverse pregnancy outcomes (APOs) and treatments in systemic lupus erythematosus (SLE) pregnancies in Sweden over 2003‐2022. Methods Using nationwide Swedish registers…
View article: Preterm birth in women with psoriatic arthritis: what are the risks and risk factors? A collaborative cohort study from Sweden, Denmark and Norway
Preterm birth in women with psoriatic arthritis: what are the risks and risk factors? A collaborative cohort study from Sweden, Denmark and Norway Open
Objective To estimate risk and to identify risk factors for preterm birth in pregnant women with psoriatic arthritis (PsA) in relation to maternal characteristics, treatment and disease activity, both before and during pregnancy. Methods W…
View article: Pregnancy Outcomes in Women With Systemic Sclerosis Before and/or After Diagnosis and by Parity: A Swedish Population‐Based Cohort Study
Pregnancy Outcomes in Women With Systemic Sclerosis Before and/or After Diagnosis and by Parity: A Swedish Population‐Based Cohort Study Open
Objective To assess risks of adverse pregnancy outcomes (APOs) in a contemporary cohort of women with systemic sclerosis (SSc) in relation to the timing of SSc diagnosis and by parity. Methods From the nationwide Swedish Medical Birth Regi…
View article: Determination of prednisolone concentration in human breast milk and plasma of breastfed infants: study protocol of a Swedish multicentre low-intervention clinical trial
Determination of prednisolone concentration in human breast milk and plasma of breastfed infants: study protocol of a Swedish multicentre low-intervention clinical trial Open
Introduction Many women need to use medications during breastfeeding. Very few medications have been adequately monitored, tested and labelled with safety information for this use. Prednisolone is one of these drugs. We aim to conduct a mu…
View article: Non‐steroidal anti‐inflammatory drugs and risk of kidney cancer: A Swedish nationwide cohort study in the general and high‐use populations
Non‐steroidal anti‐inflammatory drugs and risk of kidney cancer: A Swedish nationwide cohort study in the general and high‐use populations Open
Background Data on the association between non‐steroidal anti‐inflammatory drugs (NSAIDs) and kidney cancer (KC) are conflicting. This study aimed to evaluate this association in the general population and in patients with extensive NSAID …
View article: Impact of cancer on the mortality of patients with idiopathic inflammatory myopathies by flexible parametric multistate modelling
Impact of cancer on the mortality of patients with idiopathic inflammatory myopathies by flexible parametric multistate modelling Open
Background Patients with idiopathic inflammatory myopathies (IIM) have an increased risk of cancer, but their cancer‐related disease burden remains unclear. Objectives To explore how cancer might impact the mortality of patients with IIM a…
View article: Hydroxychloroquine in lupus or rheumatoid arthritis pregnancy and risk of major congenital malformations: a population-based cohort study
Hydroxychloroquine in lupus or rheumatoid arthritis pregnancy and risk of major congenital malformations: a population-based cohort study Open
Objectives To assess the infant risk of major congenital malformations (MCM) associated with first-trimester exposure to hydroxychloroquine (HCQ) among mothers with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). Methods T…
View article: Prevalence of coeliac disease in patients with systemic lupus erythematosus: a systematic review and meta-analysis
Prevalence of coeliac disease in patients with systemic lupus erythematosus: a systematic review and meta-analysis Open
Background There is some evidence of a higher prevalence of coeliac disease (CD) among patients with SLE than in the general population. However, the prevalence estimates vary substantially. Objective To investigate the prevalence of CD am…
View article: Association of childhood infections and perinatal factors with ankylosing spondylitis: a Swedish nationwide case–control and sibling study
Association of childhood infections and perinatal factors with ankylosing spondylitis: a Swedish nationwide case–control and sibling study Open
Objectives To identify perinatal and early-life risk factors for ankylosing spondylitis (AS), controlling for family-shared confounding with a sibling comparison design. Methods In this nationwide, register-based case–control study, we ide…
View article: LO-026 Hydroxychloroquine use in pregnant women with systemic lupus erythematosus and major congenital malformations in the offspring
LO-026 Hydroxychloroquine use in pregnant women with systemic lupus erythematosus and major congenital malformations in the offspring Open
Background Some studies have reported an increased risk of major congenital malformations (MCM) associated with hydroxychloroquine (HCQ), but others find no increased risk. We aim to assess the risk of MCM associated with 1st-trimester HCQ…
View article: Familial <scp>Co‐Aggregation</scp> of Idiopathic Inflammatory Myopathies and Cancer: A Swedish <scp>Population‐Based</scp> Study
Familial <span>Co‐Aggregation</span> of Idiopathic Inflammatory Myopathies and Cancer: A Swedish <span>Population‐Based</span> Study Open
Objective To examine if idiopathic inflammatory myopathies (IIMs) share familial susceptibility with cancer, we estimated the familial co‐aggregation of these diseases. Methods This Swedish population‐based family study with data from nati…
View article: Exposure to specific tumour necrosis factor inhibitors and risk of demyelinating and inflammatory neuropathy in cohorts of patients with inflammatory arthritis: a collaborative observational study across five Nordic rheumatology registers
Exposure to specific tumour necrosis factor inhibitors and risk of demyelinating and inflammatory neuropathy in cohorts of patients with inflammatory arthritis: a collaborative observational study across five Nordic rheumatology registers Open
Objective To compare incidences of neuroinflammatory events, including demyelinating disease (DML), inflammatory polyneuropathies (IPN) and multiple sclerosis (MS), in patients with rheumatoid arthritis (RA) or spondyloarthritis (SpA; incl…
View article: Haematological malignancies in patients with psoriatic arthritis overall and treated with TNF inhibitors: a Nordic cohort study
Haematological malignancies in patients with psoriatic arthritis overall and treated with TNF inhibitors: a Nordic cohort study Open
Objectives To evaluate the risk of haematological malignancies in patients with psoriatic arthritis (PsA) overall, and in relation to treatment with tumour necrosis factor inhibitors (TNFi). Methods We identified that patients with PsA sta…
View article: Risk of pre-eclampsia and impact of disease activity and antirheumatic treatment in women with rheumatoid arthritis, axial spondylarthritis and psoriatic arthritis: a collaborative matched cohort study from Sweden and Denmark
Risk of pre-eclampsia and impact of disease activity and antirheumatic treatment in women with rheumatoid arthritis, axial spondylarthritis and psoriatic arthritis: a collaborative matched cohort study from Sweden and Denmark Open
Objective To explore the risk of pre-eclampsia in rheumatoid arthritis (RA), axial spondyloarthritis (AxSpA) and psoriatic arthritis (PsA), focusing on the impact of treatment and disease activity. Methods We identified RA, AxSpA and PsA s…
View article: Familial autoimmunity in patients with idiopathic inflammatory myopathies
Familial autoimmunity in patients with idiopathic inflammatory myopathies Open
Background Familial associations can be indicators of shared genetic susceptibility between two diseases. Previous data on familial autoimmunity in patients with idiopathic inflammatory myopathies (IIM) are scarce and inconsistent. Objecti…
View article: Pregnancy Outcomes in Women With Psoriatic Arthritis in Relation to Presence and Timing of Antirheumatic Treatment
Pregnancy Outcomes in Women With Psoriatic Arthritis in Relation to Presence and Timing of Antirheumatic Treatment Open
Objective To evaluate pregnancy outcomes in relation to antirheumatic treatment before and during pregnancy, as a proxy of disease severity in pregnant women with psoriatic arthritis (PsA), compared to those without PsA. Methods Our study …
View article: Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies Open
IIM has a familial component with a risk of aggregation among first-degree relatives and a heritability of about 20%. This information is of importance for future aetiological studies and in clinical counselling.
View article: Is family history a predictor of response to tumour necrosis factor inhibitors in spondyloarthritis? A Swedish nationwide cohort study
Is family history a predictor of response to tumour necrosis factor inhibitors in spondyloarthritis? A Swedish nationwide cohort study Open
Objective: To determine whether a family history of spondyloarthritis (SpA) is associated with clinical presentation at the start of tumour necrosis factor inhibitor (TNFi) treatment, or predictive of TNFi drug survival and treatment respo…
View article: Overall and site-specific cancer before and after diagnosis of idiopathic inflammatory myopathies: A nationwide study 2002–2016
Overall and site-specific cancer before and after diagnosis of idiopathic inflammatory myopathies: A nationwide study 2002–2016 Open
The cancer types that occur before IIM diagnosis differ from the ones that occur after diagnosis. This may have an impact on screening decisions for IIM.
View article: Paediatric infections in the first 3 years of life after maternal anti‐TNF treatment during pregnancy
Paediatric infections in the first 3 years of life after maternal anti‐TNF treatment during pregnancy Open
Summary Background Most anti‐tumour necrosis factor (anti‐TNF) agents are transferred across the placenta and may increase paediatric susceptibility to infections. Aims To assess the risk of paediatric infections after maternal anti‐TNF tr…
View article: Pregnancy outcomes in women with idiopathic inflammatory myopathy, before and after diagnosis—a population-based study
Pregnancy outcomes in women with idiopathic inflammatory myopathy, before and after diagnosis—a population-based study Open
Objectives To examine pregnancy outcomes among births to women with idiopathic inflammatory myopathy (IIM) in relation to time of IIM diagnosis using population-based data. Methods This study used Swedish nationwide registers to identify a…
View article: Familial aggregation and heritability of ankylosing spondylitis – a Swedish nested case–control study
Familial aggregation and heritability of ankylosing spondylitis – a Swedish nested case–control study Open
Objectives AS is known to be a highly heritable disease, but previous studies on the magnitude of the familial aggregation and heritability of AS have been small and inconclusive, with familial relative risks ranging from 17 to 94. We aime…
View article: Maternal and infant pregnancy outcomes in women with psoriatic arthritis: a Swedish nationwide cohort study
Maternal and infant pregnancy outcomes in women with psoriatic arthritis: a Swedish nationwide cohort study Open
Objective Studies on pregnancy outcomes in psoriatic arthritis (PsA) are scarce and typically of small size. Available studies have reported conflicting results. The aim of this study was to describe maternal and infant pregnancy outcomes …