Karin Huizer
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View article: The Effects of Antipsychotic Dose Reduction on Movement Disorders and Cardiometabolic Indices in Patients Remitted from a First Episode of Psychosis
The Effects of Antipsychotic Dose Reduction on Movement Disorders and Cardiometabolic Indices in Patients Remitted from a First Episode of Psychosis Open
Background and Hypothesis The extent to which tapering antipsychotic (AP) attenuates AP-related movement disorders and cardiometabolic dysfunction remains unclear. We aim to investigate the long-term effects of AP-dose reduction on these a…
View article: The Effect of Exogenous Ketones on Signs and Symptoms of Schizophrenia Spectrum and Bipolar Disorders: Study Protocol for a Triple-Blind, Randomized, Controlled Crossover Pilot Study
The Effect of Exogenous Ketones on Signs and Symptoms of Schizophrenia Spectrum and Bipolar Disorders: Study Protocol for a Triple-Blind, Randomized, Controlled Crossover Pilot Study Open
View article: Spatial Transcriptomics of Schizophrenia Insular Cortex Reveals Blood-Brain Barrier Hyperglycolysis and Increased Parenchymal Mitochondrial Respiration
Spatial Transcriptomics of Schizophrenia Insular Cortex Reveals Blood-Brain Barrier Hyperglycolysis and Increased Parenchymal Mitochondrial Respiration Open
Introduction The blood-brain barrier (BBB) acts as the metabolic and immunological gatekeeper of the brain. Since alterations in neurometabolism and neuroimmunity are found in schizophrenia-spectrum disorders (SSD) which are hypothesised t…
View article: Nanobiosensing-Enabled Biorhythm Tracking for Psychiatric Disorders
Nanobiosensing-Enabled Biorhythm Tracking for Psychiatric Disorders Open
This review paper explores the transformative potential of nanobiosensing in biorhythm tracking for psychiatric disorders. Psychiatric diseases, characterized by a complex, heterogeneous and multifactorial pathophysiology, pose challenges …
View article: Potential Benefits of Ketone Therapy as a Novel Immunometabolic Treatment for Schizophrenia
Potential Benefits of Ketone Therapy as a Novel Immunometabolic Treatment for Schizophrenia Open
Rationale Current treatment options for patients with schizophrenia-spectrum disorders (SSD) remain unsatisfactory, leaving patients with persistent negative and cognitive symptoms and metabolic side effects. Therapeutic ketosis was recent…
View article: Glioma Neovascularization : The Plot Thickens
Glioma Neovascularization : The Plot Thickens Open
View article: TAMI-10. CIRCULATING ANGIOGENIC CELLS (CACS) IN GLIOBLASTOMA: TOWARDS DEFINING CRUCIAL FUNCTIONAL DIFFERENCES IN CAC-INDUCED NEOPLASTIC VERSUS REACTIVE NEOVASCULARIZATION
TAMI-10. CIRCULATING ANGIOGENIC CELLS (CACS) IN GLIOBLASTOMA: TOWARDS DEFINING CRUCIAL FUNCTIONAL DIFFERENCES IN CAC-INDUCED NEOPLASTIC VERSUS REACTIVE NEOVASCULARIZATION Open
In order to identify suitable therapeutic targets for glioma anti-angiogenic therapy, the process of neovascularization mediated by circulating angiogenic cells (CACs) needs to be scrutinized. In the present study we compared the expressio…
View article: Periostin Is Expressed by Pericytes and Is Crucial for Angiogenesis in Glioma
Periostin Is Expressed by Pericytes and Is Crucial for Angiogenesis in Glioma Open
The expression of the matricellular protein periostin has been associated with glioma progression. In previous work we found an association of periostin with glioma angiogenesis. Here, we screen gliomas for POSTN expression and identify th…
Circulating angiogenic cells in glioblastoma: toward defining crucial functional differences in CAC-induced neoplastic versus reactive neovascularization Open
View article: P11.12 Periostin is expressed by pericytes and is crucial for angiogenesis in glioma
P11.12 Periostin is expressed by pericytes and is crucial for angiogenesis in glioma Open
BACKGROUND The expression of the matricellular protein periostin has recently been associated with glioma progression and angiogenesis. The aim of the present study was to identify the cellular source of periostin expression in human gliom…
View article: P11.11 Circulating Pro-Angiogenic Cells and Proteins in Patients with Glioma and Acute Myocardial Infarction: Differences in Neovascularization between Neoplasia and Tissue Regeneration
P11.11 Circulating Pro-Angiogenic Cells and Proteins in Patients with Glioma and Acute Myocardial Infarction: Differences in Neovascularization between Neoplasia and Tissue Regeneration Open
BACKGROUND Although extensive angiogenesis takes place in glial tumors, anti-angiogenic therapies have remained without the expected success. In the peripheral circulation of glioma patients increased numbers of endothelial precursor cells…
View article: Circulating Proangiogenic Cells and Proteins in Patients with Glioma and Acute Myocardial Infarction: Differences in Neovascularization between Neoplasia and Tissue Regeneration
Circulating Proangiogenic Cells and Proteins in Patients with Glioma and Acute Myocardial Infarction: Differences in Neovascularization between Neoplasia and Tissue Regeneration Open
Although extensive angiogenesis takes place in glial tumors, antiangiogenic therapies have remained without the expected success. In the peripheral circulation of glioma patients, increased numbers of endothelial precursor cells (EPCs) are…
View article: ANGI-18. PERIOSTIN IS EXPRESSED BY PERICYTES AND PROMOTES ANGIOGENESIS UNDER THE CONTROL OF GLIAL TUMOR CELLS
ANGI-18. PERIOSTIN IS EXPRESSED BY PERICYTES AND PROMOTES ANGIOGENESIS UNDER THE CONTROL OF GLIAL TUMOR CELLS Open
Recently periostin was associated with glioma angiogenesis and in a glioma mouse model it was shown that periostin is expressed by glioma stem cells, and its expression attracks tumor associated macrophages that promote malignant growth of…
View article: Improving the characterization of endothelial progenitor cell subsets by an optimized FACS protocol
Improving the characterization of endothelial progenitor cell subsets by an optimized FACS protocol Open
The characterization of circulating endothelial progenitor cells (EPCs) is fundamental to any study related to angiogenesis. Unfortunately, current literature lacks consistency in the definition of EPC subsets due to variations in isolatio…
View article: P08.31 Periostin is expressed by pericytes and promotes angiogenesis under the control of glial tumor cells
P08.31 Periostin is expressed by pericytes and promotes angiogenesis under the control of glial tumor cells Open
In a previous study we sought proteins that are specifically expressed in the context of glioma angiogenesis. To that aim, we compared microdissected GBM vessels with normal brain vessels and vessels of proliferating endometrium representi…
View article: Evidence-Based Diagnostic Algorithm for Glioma: Analysis of the Results of Pathology Panel Review and Molecular Parameters of EORTC 26951 and 26882 Trials
Evidence-Based Diagnostic Algorithm for Glioma: Analysis of the Results of Pathology Panel Review and Molecular Parameters of EORTC 26951 and 26882 Trials Open
Purpose With the rapid discovery of prognostic and predictive molecular parameters for glioma, the status of histopathology in the diagnostic process should be scrutinized. Our project aimed to construct a diagnostic algorithm for gliomas …