Karin L. Meeker
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View article: Rates of clinical progression according to biological Alzheimer's disease stages
Rates of clinical progression according to biological Alzheimer's disease stages Open
INTRODUCTION Predicting the rate of cognitive decline and the likelihood of progression to dementia remains a critical unmet need in clinical settings. METHODS We assessed progression to mild cognitive impairment (MCI) and all‐cause dement…
View article: Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics
Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics Open
INTRODUCTION The Health and Aging Brain Study–Health Disparities (HABS‐HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description of the cohort baseline characteristics and ou…
View article: Cross‐Sectional Comparison of Structural <scp>MRI</scp> Markers of Impairment in a Diverse Cohort of Older Adults
Cross‐Sectional Comparison of Structural <span>MRI</span> Markers of Impairment in a Diverse Cohort of Older Adults Open
Neurodegeneration is presumed to be the pathological process measure most proximal to clinical symptom onset in Alzheimer Disease (AD). Structural MRI is routinely collected in research and clinical trial settings. Several quantitative MRI…
View article: Establishing tau-PET cut-points for cognitive diagnosis with 18F-PI-2620 in a multi-ethnoracial cohort
Establishing tau-PET cut-points for cognitive diagnosis with 18F-PI-2620 in a multi-ethnoracial cohort Open
18F-PI-2620 is a newer tau-PET tracer with minimal off-target binding in the choroid plexus. Defining tau cut-points to differentiate between cognitively unimpaired and impaired individuals is crucial for both biomarker validation and clin…
View article: Characterization of plasma AT(N) biomarkers among a racial and ethnically diverse community‐based cohort: an HABS‐HD study
Characterization of plasma AT(N) biomarkers among a racial and ethnically diverse community‐based cohort: an HABS‐HD study Open
INTRODUCTION Alzheimer's disease (AD) biomarkers of Amyloid(A), Tau(T), and Neurodegeneration(N) have been increasingly studied to fill the gap in our understanding of racial and ethnic differences. This study aimed to examine the relation…
View article: Cross‐Sectional Comparison of Structural MRI Markers of Cognitive Impairment in an Ethno‐racially Diverse Cohort
Cross‐Sectional Comparison of Structural MRI Markers of Cognitive Impairment in an Ethno‐racially Diverse Cohort Open
Background Structural MRI can describe neurodegeneration associated with aging and Alzheimer Disease (AD). Brain age gap (BAG) quantifies the difference between chronological age and predicted “brain age” and can be estimated using many pu…
View article: Alzheimer disease ATN imaging biomarkers across type 2 diabetes mellitus stages in diverse populations
Alzheimer disease ATN imaging biomarkers across type 2 diabetes mellitus stages in diverse populations Open
Background Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD) and disproportionately impacts under‐represented groups including Mexican Americans/Hispanics (MAs) and African Americans/Blacks (AAs) compared to non‐H…
View article: The importance of AT(N)‐V imaging biomarkers differs in diverse populations
The importance of AT(N)‐V imaging biomarkers differs in diverse populations Open
Background Investigations into the amyloid, tau, and neurodegeneration (ATN) framework, which is used to stage Alzheimer disease (AD) and advance clinical trials, typically consist of clinic‐based non‐Hispanic White (NHW) populations. The …
View article: Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer’s disease
Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer’s disease Open
Alzheimer’s disease biomarkers are crucial to understanding disease pathophysiology, aiding accurate diagnosis and identifying target treatments. Although the number of biomarkers continues to grow, the relative utility and uniqueness of e…
View article: Characterizing plasma biomarkers of the ATN framework among a diverse community‐dwelling cohort: A HABS‐HD study
Characterizing plasma biomarkers of the ATN framework among a diverse community‐dwelling cohort: A HABS‐HD study Open
Background The A/T/N research framework for Alzheimer’s Disease calls for the importance of examining differences in these biomarkers across racial and ethnic groups. This study aims to address this need and examine the correlation and app…
View article: Effects of structural and social determinants of health and comorbidities on ethno‐racial differences in ATN plasma biomarkers of Alzheimer’s disease: A HABS‐HD study
Effects of structural and social determinants of health and comorbidities on ethno‐racial differences in ATN plasma biomarkers of Alzheimer’s disease: A HABS‐HD study Open
Background Ethno‐racial differences are observed in amyloid (A), tau (T), and neurodegeneration (N) plasma biomarkers of Alzheimer’s disease (AD). In neuroimaging studies, structural and social determinant of health (SSDOH) factors and ass…
View article: A machine learning examination of the utility of CSF, neuroimaging, and plasma biomarkers in late onset Alzheimer Disease
A machine learning examination of the utility of CSF, neuroimaging, and plasma biomarkers in late onset Alzheimer Disease Open
Background Alzheimer disease (AD) biomarkers are crucial to understanding disease pathophysiology, aiding accurate diagnosis, and identifying target treatments. Although the number of biomarkers continues to grow, the utility and uniquenes…
View article: Resting state network mapping in individuals using deep learning
Resting state network mapping in individuals using deep learning Open
Introduction Resting state functional MRI (RS-fMRI) is currently used in numerous clinical and research settings. The localization of resting state networks (RSNs) has been utilized in applications ranging from group analysis of neurodegen…
View article: Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage
Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage Open
CSF NfL is a non-specific marker of aging and white matter integrity with limited sensitivity to specific markers of AD. CSF NfL likely reflects processes associated with cerebrovascular disease.
View article: Network dysfunction in cognitively normal <i>APOE</i> ε4 carriers is related to subclinical tau
Network dysfunction in cognitively normal <i>APOE</i> ε4 carriers is related to subclinical tau Open
Introduction Apolipoprotein E ( APOE ) ε4 allele status is associated with amyloid and tau‐related pathological changes related to Alzheimer's disease (AD). However, it is unknown whether brain network changes are related to amyloid beta (…
View article: Neuroimaging the Neuropathogenesis of HIV
Neuroimaging the Neuropathogenesis of HIV Open
View article: Modeling autosomal dominant Alzheimer's disease with machine learning
Modeling autosomal dominant Alzheimer's disease with machine learning Open
Introduction Machine learning models were used to discover novel disease trajectories for autosomal dominant Alzheimer's disease. Methods Longitudinal structural magnetic resonance imaging, amyloid positron emission tomography (PET), and f…
View article: Issue Information
Issue Information Open
Canada & Mexico), €1286.00(Europe), £1020.00(UK), US$1993.00 (Rest of World).Prices are exclusive of tax.Asia-Pacific GST,
View article: Socioeconomic status mediates racial differences seen using the AT(N) framework
Socioeconomic status mediates racial differences seen using the AT(N) framework Open
Background Previous research suggests that African Americans are potentially at greater risk for developing Alzheimer disease (AD). Genetic, social, environmental, and cardiovascular factors may increase the risk of AD. The objectives of t…
View article: Neurofilament light is a non‐specific marker of aging and white matter integrity
Neurofilament light is a non‐specific marker of aging and white matter integrity Open
Background Neurofilament light chain (NfL) is considered a biomarker of neuronal injury and degeneration and is increasingly used to evaluate disease progression across multiple neurological conditions including Alzheimer Disease (AD). Des…
View article: Default mode network dedifferentiation predicts cognitive performance in Alzheimer disease
Default mode network dedifferentiation predicts cognitive performance in Alzheimer disease Open
Background During aging, brain networks become less functionally specialized, known as dedifferentiation. When dedifferentiation occurs, brain networks become less adaptive, leading to failures in cognitive processing. Although global dedi…
View article: Cerebrospinal fluid Aβ42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability
Cerebrospinal fluid Aβ42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability Open
View article: Socioeconomic Status Mediates Racial Differences Seen Using the<scp>AT(N)</scp>Framework
Socioeconomic Status Mediates Racial Differences Seen Using the<span>AT(N)</span>Framework Open
Objectives African Americans are at greater risk for developing Alzheimer's disease (AD) dementia than non‐Hispanic whites. In addition to biological considerations (eg, genetic influences and comorbid disorders), social and environmental …
View article: Sex-related Differences in Tau Positron Emission Tomography (PET) and the Effects of Hormone Therapy (HT)
Sex-related Differences in Tau Positron Emission Tomography (PET) and the Effects of Hormone Therapy (HT) Open
Importance: Female sex is a major risk factor for late-onset Alzheimer disease (AD), and sex hormones have been implicated as a possible protective factor. Neuroimaging studies that evaluated the effects of sex hormones on brain integrity …
View article: P3‐379: COGNITIVE INTRAINDIVIDUAL VARIABILITY IN EARLY ALZHEIMER'S DISEASE IS RELATED TO WEAKENING OF FUNCTIONAL NETWORK ANTICORRELATIONS
P3‐379: COGNITIVE INTRAINDIVIDUAL VARIABILITY IN EARLY ALZHEIMER'S DISEASE IS RELATED TO WEAKENING OF FUNCTIONAL NETWORK ANTICORRELATIONS Open
In cognitively normal older adults, task-positive networks, such as the dorsal attention network (DAN), show greater neural recruitment in response to attention-demanding tasks than at rest, whereas the task-negative default mode network (…