Karin Mellgren
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View article: Late effects after hematopoietic stem cell transplantation in patients with HLH: A Histiocyte Society, PDWP, IEWP, and TCWP EBMT Study
Late effects after hematopoietic stem cell transplantation in patients with HLH: A Histiocyte Society, PDWP, IEWP, and TCWP EBMT Study Open
HCT has significantly improved survival in patients with pHLH. However, survivors still face significant risks of LEs.
View article: 2 Pediatric clinical trials need pediatric clinical trial budgets
2 Pediatric clinical trials need pediatric clinical trial budgets Open
There is a well-known knowledge gap regarding the efficacy and safety of medicines in children of all ages, and clinical trials and the need for new treatments were recently listed among the most important factors for child health. Pediat…
View article: Meals are more than nutrition for children with a malignant or non-malignant disorder with a gastrostomy tube: A qualitative study
Meals are more than nutrition for children with a malignant or non-malignant disorder with a gastrostomy tube: A qualitative study Open
Hospital environment and hospital food have a profound impact on children's nutritional intake and mealtime situations. In addition, sensory aspects and side effects aggravate the child's motivation to eat, resulting in demanding meals. Th…
View article: Heart failure in patients with congenital heart disease after a cancer diagnosis
Heart failure in patients with congenital heart disease after a cancer diagnosis Open
Aims Individuals with congenital heart disease (CHD) are at an increased risk for cancer. As cancer survival rates improve, the prevalence of late side effects, such as heart failure (HF), is becoming more evident. This study aims to evalu…
View article: Intensive care in children with <scp>non‐Hodgkin</scp> lymphoma in Sweden
Intensive care in children with <span>non‐Hodgkin</span> lymphoma in Sweden Open
Funding Agencies|Swedish Childhood Cancer Fund; Swedish Intensive Care
View article: Outcomes after cancer diagnosis in children and adult patients with congenital heart disease in Sweden: a registry-based cohort study
Outcomes after cancer diagnosis in children and adult patients with congenital heart disease in Sweden: a registry-based cohort study Open
Objective Patients with congenital heart disease (CHD) have an increased cancer risk. The aim of this study was to determine cancer-related mortality in CHD patients compared with non-CHD controls, compare ages at cancer diagnosis and deat…
View article: Hematopoietic stem cell transplantation for pediatric patients with non-anaplastic peripheral T-cell lymphoma. An EBMT pediatric diseases working party study
Hematopoietic stem cell transplantation for pediatric patients with non-anaplastic peripheral T-cell lymphoma. An EBMT pediatric diseases working party study Open
Peripheral T-cell lymphomas (PTCL) other than anaplastic large-cell lymphoma are rare in children, and the role of hematopoietic stem cell transplantation (HSCT) has not been clarified yet. In a retrospective analysis of registry-data of t…
View article: CD38 as a therapeutic target in pediatric Burkitt’s Lymphoma: insights from a comparative approach (Running title: Targeting CD38 in pediatric Burkitt's Lymphoma)
CD38 as a therapeutic target in pediatric Burkitt’s Lymphoma: insights from a comparative approach (Running title: Targeting CD38 in pediatric Burkitt's Lymphoma) Open
Background Pediatric Burkitt's lymphoma (pBL) is the most common childhood non-Hodgkin's B-cell lymphoma. Despite the encouraging survival rates for most children, treating cases with relapse and resistance to current therapies remains cha…
View article: Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B cells
Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B cells Open
Objectives Paediatric Burkitt's lymphoma (pBL) is the most common childhood non‐Hodgkin B‐cell lymphoma. Despite the encouraging survival rates for most children, treating cases with relapse/resistance to current therapies remains challeng…
View article: A Potential Paradigm for the Robust and Systematic Prioritisation of Assets in Academic-Led, Multi-Industry Collaborative Trials in Rare Populations (Glo-BNHL)
A Potential Paradigm for the Robust and Systematic Prioritisation of Assets in Academic-Led, Multi-Industry Collaborative Trials in Rare Populations (Glo-BNHL) Open
Overview Given the rarity of children and adolescents with relapsed and refractory (r/r) B-cell Non-Hodgkin Lymphoma (B-NHL) and the large number of potential agents in development for adult mature B-cell malignancies, there is urgent need…
View article: Paediatric clinical trials need paediatric clinical trial budgets
Paediatric clinical trials need paediatric clinical trial budgets Open
Aim Clinical trials and the need for new treatments were recently listed among the most important factors for child health. The aim of the present study was to describe some of our experiences with budget preparations in paediatric clinica…
View article: A retrospective case–control study of gastrostomy use in children undergoing hematopoietic cell transplantation
A retrospective case–control study of gastrostomy use in children undergoing hematopoietic cell transplantation Open
Background Maintaining a good nutritional status during the hematopoietic cell transplantation (HCT) procedure is challenging in the pediatric population. Methods In a multicentric retrospective study, we compared the outcome of nutritiona…
View article: Pain and discomfort in children with gastrostomy tubes – In the context of hematopoietic stem cell transplantation
Pain and discomfort in children with gastrostomy tubes – In the context of hematopoietic stem cell transplantation Open
The paediatric care team need competence in assessing G-tube related pain and awareness that experiences may differ depending on the child's disorder.
View article: Highly-sensitive chimerism analysis in blood after allogeneic hematopoietic cell transplantation in childhood leukemia: Results from the Nordic Microchimerism Study
Highly-sensitive chimerism analysis in blood after allogeneic hematopoietic cell transplantation in childhood leukemia: Results from the Nordic Microchimerism Study Open
Analysis of chimerism in blood post‐HCT using STR‐PCR is routinely applied in parallel with quantification of MRD to predict relapse of leukemia. Real time quantitative PCR (RQ-PCR) chimerism is 10‐ to 100‐fold more sensitive, but clinical…
View article: Pediatric Precursor B-Cell Lymphoblastic Malignancies: From Extramedullary to Medullary Involvement
Pediatric Precursor B-Cell Lymphoblastic Malignancies: From Extramedullary to Medullary Involvement Open
B-cell lymphoblastic lymphoma (BCP-LBL) and B-cell acute lymphoblastic leukemia (BCP-ALL) are the malignant counterparts of immature B-cells. BCP-ALL is the most common hematological malignancy in childhood, while BCP-LBL accounts for only…
View article: Immunological differences between heart- and kidney-transplanted children: a cross-sectional study – CORRIGENDUM
Immunological differences between heart- and kidney-transplanted children: a cross-sectional study – CORRIGENDUM Open
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View article: Immunological differences between heart- and kidney-transplanted children: a cross-sectional study
Immunological differences between heart- and kidney-transplanted children: a cross-sectional study Open
Post-transplantation lymphoproliferative disorder is a potentially mortal complication after heart transplantation in children. As the immune system plays a crucial role in the development of lymphoma, we explored the influence of thymus f…
View article: Patient parameters and response after administration of rituximab in pediatric mature B‐cell non‐Hodgkin lymphoma
Patient parameters and response after administration of rituximab in pediatric mature B‐cell non‐Hodgkin lymphoma Open
Background Mature aggressive B‐cell lymphomas are heterogenous malignancies that make up more than half of all diagnosed non‐Hodgkin lymphoma in children and adolescents. The overall survival rate increased over the last decades to 80%–90%…
View article: Characterization of tumor response after administration of rituximab in pediatric B-NHL
Characterization of tumor response after administration of rituximab in pediatric B-NHL Open
Background Mature aggressive B-cell lymphoma are heterogenous malignancies that make up more than half of all diagnosed Non-Hodgkin lymphoma in children and adolescents. The overall survival rate increased over the last decades to 80–90%, …
View article: Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations
Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations Open
Despite poor survival, controversies remain in the treatment for refractory or relapsed pediatric non-Hodgkin lymphoma (r/r NHL). The current project aimed to collect international experience on the re-induction treatment of r/r NHL, hemat…
View article: The five aspect meal model as a conceptual framework for children with a gastrostomy tube in paediatric care
The five aspect meal model as a conceptual framework for children with a gastrostomy tube in paediatric care Open
Background Cancer treatments may induce side effects and cause eating problems. A gastrostomy tube may be required in order to maintain and optimise the child's nutritional needs. Despite the use of a gastrostomy tube, it is important to m…
View article: Experiences before and after nasogastric and gastrostomy tube insertion with emphasis on mealtimes: a case study of an adolescent with cerebral palsy
Experiences before and after nasogastric and gastrostomy tube insertion with emphasis on mealtimes: a case study of an adolescent with cerebral palsy Open
Purpose: Adolescents with cerebral palsy may need a feeding tube due to feeding challenges, since nutritional intake and mealtimes may be negatively affected. The purpose of the study was to describe and better understand how one adolescen…
View article: A validated pediatric disease risk index for allogeneic hematopoietic cell transplantation
A validated pediatric disease risk index for allogeneic hematopoietic cell transplantation Open
A disease risk index (DRI) that was developed for adults with hematologic malignancy who were undergoing hematopoietic cell transplantation is also being used to stratify children and adolescents by disease risk. Therefore, to develop and …