Karine Dubé
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View article: Envisioning a Multidisciplinary HBV Cure Research Agenda
Envisioning a Multidisciplinary HBV Cure Research Agenda Open
View article: Motivations, acceptability and ethical considerations for interventional HIV cure research at the end of life: perspectives from long-term survivors of HIV in the United States
Motivations, acceptability and ethical considerations for interventional HIV cure research at the end of life: perspectives from long-term survivors of HIV in the United States Open
Introduction Despite progress in antiretroviral therapy (ART), an effective cure for HIV remains out of reach. End-of-life (EOL) research studies involving individuals with a prognosis of six months or less offers an opportunity to advance…
View article: Resolving Challenges in HIV Cure–Related Research: Protocol for a Modified Delphi Consensus-Building Process
Resolving Challenges in HIV Cure–Related Research: Protocol for a Modified Delphi Consensus-Building Process Open
Background HIV cure–related research is expanding rapidly, bringing both new opportunities and ethical challenges. Historically, clinical trials for novel HIV treatments have underrepresented populations most affected by HIV, such as Black…
View article: Relationship Between Opioid Use, Depression, and Quality of Life Among Persons With HIV at End of Life
Relationship Between Opioid Use, Depression, and Quality of Life Among Persons With HIV at End of Life Open
View article: Every Body Has Value: Ending Discriminatory Restrictions on Anatomical Donations
Every Body Has Value: Ending Discriminatory Restrictions on Anatomical Donations Open
Anatomical body donation plays a critical role in medical education and scientific discovery. Yet, most programs in the United States continue to exclude individuals with human immunodeficiency virus (HIV) or viral hepatitis, despite moder…
View article: “This Is How I Give Back”: Long-Term Survivors on Legacy and HIV Cure Research at the End of Life—A Qualitative Inquiry in the United States
“This Is How I Give Back”: Long-Term Survivors on Legacy and HIV Cure Research at the End of Life—A Qualitative Inquiry in the United States Open
Background/Objectives: End-of-life (EOL) HIV cure research, which studies HIV persistence through pre- and post-mortem tissue collection, has focused primarily on people living with HIV (PLWH) with a prognosis of six months or less. Howeve…
View article: “A cure might help, but it won't erase it all”: a qualitative study of policy challenges and priorities for long‐term survivors of HIV in the United States
“A cure might help, but it won't erase it all”: a qualitative study of policy challenges and priorities for long‐term survivors of HIV in the United States Open
Introduction Long‐term survivors (LTS) of HIV, including individuals diagnosed before the availability of effective antiretroviral therapy (ART), have played a pivotal role in shaping the HIV response. Despite an increase in their number i…
View article: Achieving the global agenda toward HIV cure calls for establishing a research-for-cure academy in West and Central Africa
Achieving the global agenda toward HIV cure calls for establishing a research-for-cure academy in West and Central Africa Open
View article: Matters Arising: on the willingness to trade-off years of life for an HIV cure
Matters Arising: on the willingness to trade-off years of life for an HIV cure Open
This Matters Arising explores the article titled "Willingness to Trade-Off Years of Life for an HIV Cure- An Experimental Exploration of Affective Forecasting," published in AIDS Research and Therapy in August 2024. We highlight the import…
View article: ‘It is scary to pause treatment’: perspectives on HIV cure-related research and analytical treatment interruptions from women diagnosed during acute HIV in Durban, South Africa
‘It is scary to pause treatment’: perspectives on HIV cure-related research and analytical treatment interruptions from women diagnosed during acute HIV in Durban, South Africa Open
Understanding women's perspectives on HIV cure research, especially ATI trials, is vital. Building trust and addressing psychosocial challenges through a healing-centered approach can facilitate trial participation. Socio-behavioral resear…
View article: Standard of prevention for infectious diseases' prevention clinical trials during pandemics: learning lessons for global policies from biomedical HIV prevention clinical trials and a case study of COVID-19
Standard of prevention for infectious diseases' prevention clinical trials during pandemics: learning lessons for global policies from biomedical HIV prevention clinical trials and a case study of COVID-19 Open
Lessons from biomedical HIV prevention research indicate that standard of prevention packages evolve over time, and require active engagement of stakeholders and community advocates to define packages accept to community members and trial …
View article: Quality of Life in People With HIV at the End of Life: Preliminary Results From the Last Gift Observational Cohort Study
Quality of Life in People With HIV at the End of Life: Preliminary Results From the Last Gift Observational Cohort Study Open
Background: As people living with HIV (PWH) age, they face new challenges that can have a negative impact on their quality of life (QOL) and mental health. Setting: This study enrolled PWH at the end of life (EOL) who were actively engaged…
View article: Partner protections in HIV cure-related trials involving analytical treatment interruption: Updated toolkit to mitigate HIV transmission risk
Partner protections in HIV cure-related trials involving analytical treatment interruption: Updated toolkit to mitigate HIV transmission risk Open
View article: “This Is Actually a Really Unique Moment in Time”: Navigating Long-Acting HIV Treatment and HIV Cure Research with Analytical Treatment Interruptions—A Qualitative Interview Study in the United States
“This Is Actually a Really Unique Moment in Time”: Navigating Long-Acting HIV Treatment and HIV Cure Research with Analytical Treatment Interruptions—A Qualitative Interview Study in the United States Open
Advancements in long-acting (LA) HIV treatment and cure research with analytical treatment interruptions (ATIs) have generated important scientific and implementation questions. There is an urgent need to examine challenges navigating the …
View article: Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States
Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States Open
Our findings demonstrate potential improvements for future ATI trial participant experiences, such as more robust resources for psychosocial support and partner protections. Dedicating greater effort to understanding participant ATI experi…
View article: Call for justice-informed HIV cure trials with ATIs
Call for justice-informed HIV cure trials with ATIs Open
View article: Perceptions and experiences of daily and long-acting pre-exposure prophylaxis (PrEP) among MSM in India
Perceptions and experiences of daily and long-acting pre-exposure prophylaxis (PrEP) among MSM in India Open
Oral pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy with high efficacy. An increased willingness to use PrEP among at-risk Indian men who have sex with men (MSM) population has been reported; however, little is kno…
View article: Perceptions and experiences of daily and long-acting pre-exposure prophylaxis (PrEP) among MSM in India
Perceptions and experiences of daily and long-acting pre-exposure prophylaxis (PrEP) among MSM in India Open
Oral pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy with high efficacy. An increased willingness to use PrEP among at-risk Indian men who have sex with men (MSM) population has been reported; however, little is kno…
View article: Patient acceptability of, and attitudes towards, hepatitis B cure research – A scoping review and identification of knowledge gaps
Patient acceptability of, and attitudes towards, hepatitis B cure research – A scoping review and identification of knowledge gaps Open
View article: People with HIV at the end-of-life and their next-of-kin/loved ones are willing to participate in interventional HIV cure-related research
People with HIV at the end-of-life and their next-of-kin/loved ones are willing to participate in interventional HIV cure-related research Open
Introduction: The Last Gift study at the University of California San Diego (UCSD), United States enrolls terminally ill people with HIV (PWH) in HIV cure research. Methods: From 2017 to 2022, we conducted surveys with Last Gift participan…
View article: Increasing the meaningful involvement of women in HIV cure-related research: a qualitative interview study in the United States
Increasing the meaningful involvement of women in HIV cure-related research: a qualitative interview study in the United States Open
Our empirical inquiry extends recent calls to action to increase diversity of people involved in HIV cure research. Redressing the under-inclusion of women in HIV cure research is an urgent imperative. The entire field must mobilize and re…
View article: ‘With this study, we have hope that something is coming’: community members’ perceptions of HIV cure-related research in Durban, South Africa – a qualitative focus group study
‘With this study, we have hope that something is coming’: community members’ perceptions of HIV cure-related research in Durban, South Africa – a qualitative focus group study Open
With HIV cure trials set to launch across Africa in the future, there is a critical need to better understand and respond to local community needs and preferences and to adopt this as standard practice prior to regional trial implementatio…
View article: Perceived and Enacted HIV-Related Stigma in Eastern and Southern Sierra Leone: A Psychometric Study of an HIV Stigma Scale
Perceived and Enacted HIV-Related Stigma in Eastern and Southern Sierra Leone: A Psychometric Study of an HIV Stigma Scale Open
Background HIV stigma continues to hinder the care of people with HIV (PWH), especially in low-resource settings. We aimed to adapt and validate a concise HIV stigma scale for perceived HIV stigma in Sierra Leone. Methods We enrolled parti…
View article: A partner protection package for HIV cure-related trials involving analytical treatment interruptions
A partner protection package for HIV cure-related trials involving analytical treatment interruptions Open
View article: Vulnerability in Biomedical Research: A Historical Reflection and Practical Implications for HIV Cure-Related Research
Vulnerability in Biomedical Research: A Historical Reflection and Practical Implications for HIV Cure-Related Research Open
The concept of vulnerability in bioethics was first referenced in 1979, when the Belmont Report highlighted the need for special consideration of certain populations in the application of its general principles of respect for persons, bene…
View article: A Community-Driven Framework to Prioritize the Use of Donated Human Biological Materials in the Context of HIV Cure-Related Research at the End of Life
A Community-Driven Framework to Prioritize the Use of Donated Human Biological Materials in the Context of HIV Cure-Related Research at the End of Life Open
Initiated in 2017 after extensive community engagement, the Last Gift program enrolls altruistic volunteers willing to donate their cells and tissues at the end of life to allow studies on HIV reservoir dynamics across anatomical sites. As…
View article: Brief Report: The Influence of the COVID-19 Pandemic on the Physical, Social, and Mental Health of Black and Latinx Young People With HIV in the United States
Brief Report: The Influence of the COVID-19 Pandemic on the Physical, Social, and Mental Health of Black and Latinx Young People With HIV in the United States Open
Background: Whereas national attention has been paid to the ongoing mental health crises among young people triggered by the COVID-19 pandemic, less is known about the social, physical and psychological impacts of COVID-19 on young people …
View article: Preferences for HIV Treatment Formulations Among Young Adults With HIV in the United States
Preferences for HIV Treatment Formulations Among Young Adults With HIV in the United States Open
INTRODUCTION In the US, youth and young adults with HIV (YWH) experience significant disparities regarding HIV clinical outcomes.1–5 Compared with older people with HIV (PWH), YWH have lower rates of antiretroviral therapy (ART) initiation…
View article: Lessons for Understanding Central Nervous System HIV Reservoirs from the Last Gift Program
Lessons for Understanding Central Nervous System HIV Reservoirs from the Last Gift Program Open
Purpose of Review Deep tissue HIV reservoirs, especially within the central nervous system (CNS), are understudied due to the challenges of sampling brain, spinal cord, and other tissues. Understanding the cellular characteristics and vira…
View article: Willingness of Racially Diverse Young Adults Living with HIV to Participate in HIV Cure Research: A Cross-Sectional Survey in the United States
Willingness of Racially Diverse Young Adults Living with HIV to Participate in HIV Cure Research: A Cross-Sectional Survey in the United States Open
Nearly half of new HIV cases in the United States are among youth. Little is known about the willingness of young adults living with HIV (YLWH) to participate in HIV cure-related research. In 2021, we recruited 271 YLWH aged 18-29 for an o…