Karine Thai
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View article: Mannose Receptor C type 2 influences autoimmune neuroinflammation and blood-brain barrier integrity
Mannose Receptor C type 2 influences autoimmune neuroinflammation and blood-brain barrier integrity Open
Relapses in Multiple Sclerosis (MS) are driven by pathogenic immune cells breaching the disrupted blood–brain barrier (BBB), leading to tissue damage and eventual disease progression1–3. Among the most effective therapies are th…
View article: Peripheral HLA-DR <sup>hi</sup> CD141 <sup>+</sup> Classical Monocytes Predict Relapse Risk and Worsening in Multiple Sclerosis
Peripheral HLA-DR <sup>hi</sup> CD141 <sup>+</sup> Classical Monocytes Predict Relapse Risk and Worsening in Multiple Sclerosis Open
Our findings suggest that the frequency of HLA-DRhiCD141+ CMs could serve as a valuable predictor of disease activity complementary to current clinical tools to guide evidence-based treatment decisions.
View article: ALCAM on human oligodendrocytes mediates CD4 T cell adhesion
ALCAM on human oligodendrocytes mediates CD4 T cell adhesion Open
Multiple sclerosis is a chronic neuroinflammatory disorder characterized by demyelination, oligodendrocyte damage/loss and neuroaxonal injury in the context of immune cell infiltration in the CNS. No neuroprotective therapy is available to…
View article: MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes
MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes Open
The trafficking of autoreactive leucocytes across the blood–brain barrier endothelium is a hallmark of multiple sclerosis pathogenesis. Although the blood–brain barrier endothelium represents one of the main CNS borders to interact with th…
View article: Identification of SARS-CoV-2–specific immune alterations in acutely ill patients
Identification of SARS-CoV-2–specific immune alterations in acutely ill patients Open
Dysregulated immune profiles have been described in symptomatic patients infected with SARS-CoV-2. Whether the reported immune alterations are specific to SARS-CoV-2 infection or also triggered by other acute illnesses remains unclear. We …
View article: Identification of SARS-CoV-2-specific immune alterations in acutely ill patients
Identification of SARS-CoV-2-specific immune alterations in acutely ill patients Open
Dysregulated immune profiles have been described in symptomatic SARS-CoV-2-infected patients. Whether the reported immune alterations are specific to SARS-CoV-2 infection or also triggered by other acute illnesses remains unclear. We perfo…