Explanipedia

Heart Failure: Sleep Abnormalities, Right Ventricular Dysfunction, and Genetic Variants—Limelight, November 2025 Open

Karl A. Nath · 2025

Shift Work and the Risk of Kidney Stones Open

Felix Knauf, Friedrich C. Luft, Karl A. Nath · 2025

Determining Risk and Predicting Disease—Limelight, August 2025 Open

Karl A. Nath · 2025

Longitudinal Study of the Vascular Glycocalyx and Urinary Podocyte Markers During Pregnancy Open

Oscar A. Garcia Valencia, Sonja Šuvakov, Haitao Tu, Darah Dilmaghani, Nataša Milić , et al. · 2025

Background We aimed to assess the longitudinal changes of glycocalyx, a proteoglycan/glycoprotein layer that lines and protects endothelial cells in normotensive pregnancies (NPs); to correlate glycocalyx parameters with kidney injury mark…

Cancer: Metabolic Risk Factors, Regional Prevalence, and the Warburg Effect - Limelight, July 2025 Open

Karl A. Nath · 2025

Determinants of Outcomes in Chronic Kidney Disease: In the Limelight - June 2025 Open

Karl A. Nath · 2025

ACE2 deficiency protects against heme protein-induced acute kidney injury Open

Anthony J. Croatt, Raman Deep Singh, Joseph P. Grande, Allan W. Ackerman, Susan B. Gurley , et al. · 2025

ACE2 protein binds heme, which we reasoned would promote heme entry into the kidney and, accordingly, heme protein-mediated acute kidney injury. Our findings support this hypothesis. This study is the first to demonstrate the biological re…

In the Limelight: March 2025 Open

Karl A. Nath · 2025

The Occurrence of Senescence in the Arteriovenous Fistula in the Rat Open

Karl A. Nath, Luis A. Juncos, Raman Deep Singh, Joseph P. Grande, Anthony J. Croatt , et al. · 2024

Key Points The rat arteriovenous fistula (AVF) model exhibits marked upregulation of p16 Ink4a and p21 Cip1 and multiple markers of senescence. Fisetin, an established vasoprotective senolytic agent, when administered for 3 weeks, increase…

Increasing Maternal Mortality in the United States: Looking Beneath and Beyond the Numbers Open

Darah Dilmaghani, Karl A. Nath, Vesna D. Garovic · 2024

In the Limelight: May 2024 Open

Karl A. Nath · 2024

In the Limelight: April 2024 Open

Karl A. Nath · 2024

Apolipoprotein E is enriched in dense deposits and is a marker for dense deposit disease in C3 glomerulopathy Open

Benjamin J. Madden, Raman Deep Singh, Mark Haas, Lílian Monteiro Pereira Palma, Alok Sharma , et al. · 2024

C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative pathway of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD), both of which are characterized by bright glomerula…

Highlights From the Current Issue – Audiovisual Summary Open

Karl A. Nath · 2024

Induction of p16Ink4a Gene Expression in Heme Protein–Induced AKI and by Heme: Pathophysiologic Implications Open

Karl A. Nath, Raman Deep Singh, Anthony J. Croatt, Allan W. Ackerman, Joseph P. Grande , et al. · 2024

Key Points In heme protein–mediated AKI (HP-AKI), a senescence phenotype promptly occurs, and increased expression of p16 Ink4a contributes to HP-AKI. Renal p16 Ink4a expression is induced by hemoglobin, myoglobin, and heme in vivo and in …

Clinicopathologic Characteristics, Etiologies, and Outcome of Secondary Oxalate Nephropathy Open

Samih H. Nasr, Anthony M. Valeri, Samar M. Said, Sanjeev Sethi, Karl A. Nath , et al. · 2024

Hemodynamic response to inhaled nitric oxide in patients with pulmonary hypertension and chronic kidney disease: A retrospective cohort study Open

Kathryn T. del Valle, Michael J. Krowka, Carrie A. Schinstock, Karl A. Nath, Charles D. Burger , et al. · 2024

Pulmonary hypertension (PH) associated with chronic kidney disease (CKD) (PH‐CKD) affects approximately 20%–40% of CKD patients and is associated with increased morbidity and mortality. PH and CKD are both pathophysiologically associated w…

In the Limelight: January 2024 Open

Karl A. Nath · 2024

In the Limelight: December 2023 Open

Karl A. Nath · 2023

Highlights From the Current Issue – Audiovisual Summary Open

Karl A. Nath · 2023

Highlights From the Current Issue – Audiovisual Summary Open

Karl A. Nath · 2023

In the Limelight: November 2023 Open

Karl A. Nath · 2023

GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle Open

George R. Marcotte, Matthew J. Miller, Hawley Kunz, Zachary C. Ryan, Matthew D. Strub , et al. · 2023

Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle-specif…

Primary and Secondary Diagnoses in Medicine: Insights From Mayo Clinic Consensus Report on Membranous Nephropathy--Executive Summary Open

Karl A. Nath, Lori A. Erickson, Vesna D. Garovic · 2023

Broadly considered, diagnoses designated as either primary or secondary in medicine are used in at least 4 different contexts. First, this designation may be used in the Clinical Impression/Report/Plan to differentiate the most salient dia…

Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification Open

Sanjeev Sethi, Laurence H. Beck, Richard J. Glassock, Mark Haas, An S. De Vriese , et al. · 2023

Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification Open

Sanjeev Sethi, Laurence H. Beck, Richard J. Glassock, Mark Haas, An S. De Vriese , et al. · 2023

Adeno‐associated virus‐9 reverses delayed gastric emptying of solids in diabetic mice Open

Xiaojie Li, Sihan Ji, Gianluca Cipriani, Matthew L. Hillestad, Seth T. Eisenman , et al. · 2023

Background Gastroparesis is defined by delayed gastric emptying (GE) without obstruction. Studies suggest targeting heme oxygenase‐1 (HO1) may ameliorate diabetic gastroparesis. Upregulation of HO1 expression via interleukin‐10 (IL‐10) in …

In the Limelight: September 2023 Open

Karl A. Nath · 2023

Highlights From the Current Issue – Audiovisual Summary Open

Karl A. Nath · 2023

Highlights From the Current Issue – Audiovisual Summary Open

Karl A. Nath · 2023

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