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View article: Risk factors for vancomycin resistance in patients with <i>Enterococcus faecium</i> bloodstream infections: an analysis of the Munich Multicentric Enterococci Cohort
Risk factors for vancomycin resistance in patients with <i>Enterococcus faecium</i> bloodstream infections: an analysis of the Munich Multicentric Enterococci Cohort Open
Enterococcus faecium is difficult to treat owing to its intrinsic and acquired resistance to antibiotics, particularly vancomycin. Vancomycin-resistant Enterococcus faecium is an important cause of bloodstream infections in healthcare sett…
View article: Identification of Filamentous Fungi: An Evaluation of Three <scp>MALDI</scp>‐<scp>TOF</scp> Mass Spectrometry Systems
Identification of Filamentous Fungi: An Evaluation of Three <span>MALDI</span>‐<span>TOF</span> Mass Spectrometry Systems Open
Background Identification of filamentous fungi still poses a major challenge to laboratories. Matrix assisted laser desorption/ionisation time of flight mass spectrometry (MALDI‐TOF MS) is a promising tool, since it offers low‐cost and fas…
View article: Rho2 regulates granulocyte-triggered stress adaptation and cell wall remodeling in Aspergillus fumigatus
Rho2 regulates granulocyte-triggered stress adaptation and cell wall remodeling in Aspergillus fumigatus Open
The airborne opportunistic fungal pathogen Aspergillus fumigatus poses a deadly threat to immunocompromised patients. Neutrophil granulocytes play a key role in the defense against invasive infections caused by this pathogen. The mechanism…
View article: Pediatric Candida Manifestations in the Orofacial Region: A Retrospective Analysis of Different Forms, Risk Factors and Species Distribution
Pediatric Candida Manifestations in the Orofacial Region: A Retrospective Analysis of Different Forms, Risk Factors and Species Distribution Open
The aim of this study was to analyze the spectrum of Candida manifestations in the orofacial region to address the lack of comprehensive data in the diverse pediatric population. This retrospective study included all positive Candida findi…
View article: Rho2 regulates granulocyte-triggered stress adaptation and cell wall remodeling in <i>Aspergillus fumigatus</i>
Rho2 regulates granulocyte-triggered stress adaptation and cell wall remodeling in <i>Aspergillus fumigatus</i> Open
The airborne opportunistic fungal pathogen Aspergillus fumigatus poses a deadly threat to immunocompromised patients. Neutrophil granulocytes play a key role in the defense against invasive infections caused by this pathogen. The mechanism…
View article: P-2136. Bronchoalveolar Lavage <i>Mucorales</i> PCR Testing in Immunocompromised Patients with and without Mold Infections
P-2136. Bronchoalveolar Lavage <i>Mucorales</i> PCR Testing in Immunocompromised Patients with and without Mold Infections Open
Background Early detection of mucormycosis is crucial for successfull treatment. Aim of the study was to evaluate the added clinical value of MucorGenius® PCR testing for detection of mucormycosis in bronchoalveolar lavage fluid (BALF) sam…
View article: Colistin, Meropenem–Vaborbactam, Imipenem–Relebactam, and Eravacycline Testing in Carbapenem-Resistant Gram-Negative Rods: A Comparative Evaluation of Broth Microdilution, Gradient Test, and VITEK 2
Colistin, Meropenem–Vaborbactam, Imipenem–Relebactam, and Eravacycline Testing in Carbapenem-Resistant Gram-Negative Rods: A Comparative Evaluation of Broth Microdilution, Gradient Test, and VITEK 2 Open
Objectives. This study aimed to evaluate and compare the performance of different assays for antimicrobial susceptibility testing (AST) and minimum inhibitory concentration (MIC) determination for reserve antibiotics in carbapenem-resistan…
View article: A comparison of two MALDI-TOF MS based assays for the detection of carbapenemases in Enterobacterales
A comparison of two MALDI-TOF MS based assays for the detection of carbapenemases in Enterobacterales Open
Carbapenem resistant (CRE) and carbapenemase producing Enterobacterales (CPE) in particular, represent a major threat for healthcare systems worldwide. Rapid, reliable, and easy to perform assays are required to enable targeted and effecti…
View article: Serum antigen tests for the diagnosis of invasive aspergillosis: a retrospective comparison of five <i>Aspergillus</i> antigen assays and one beta-D-glucan assay
Serum antigen tests for the diagnosis of invasive aspergillosis: a retrospective comparison of five <i>Aspergillus</i> antigen assays and one beta-D-glucan assay Open
Invasive aspergillosis (IA) is a life-threatening infection. Early and specific diagnosis is pivotal to ensure adequate therapy. Antigen testing from blood is a widespread and convenient diagnostic approach. Various tests for the detection…
View article: Toxic eburicol accumulation drives the antifungal activity of azoles against Aspergillus fumigatus
Toxic eburicol accumulation drives the antifungal activity of azoles against Aspergillus fumigatus Open
Azole antifungals inhibit the sterol C14-demethylase (CYP51/Erg11) of the ergosterol biosynthesis pathway. Here we show that the azole-induced synthesis of fungicidal cell wall carbohydrate patches in the pathogenic mold Aspergillus fumiga…
View article: Comparative Analysis of the Clarus Aspergillus Galactomannan Enzyme Immunoassay Prototype for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid
Comparative Analysis of the Clarus Aspergillus Galactomannan Enzyme Immunoassay Prototype for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid Open
Background Galactomannan (GM) testing using Platelia Aspergillus enzyme immunoassay (Platelia AGM) from bronchoalveolar lavage fluid (BALF) aids in early diagnosis of invasive pulmonary aspergillosis (IPA). Globally, only a minority of lab…
View article: Performance of the clarus <i>Aspergillus</i> galactomannan enzyme immunoassay prototype for the diagnosis of invasive pulmonary aspergillosis in serum
Performance of the clarus <i>Aspergillus</i> galactomannan enzyme immunoassay prototype for the diagnosis of invasive pulmonary aspergillosis in serum Open
Background Serum galactomannan (GM) testing is essential for diagnosing invasive aspergillosis (IA), particularly in immunocompromised individuals. The global lack of on‐site GM testing capacities necessitates cost‐effective alternatives, …
View article: Erratum for Rothe et al., “Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?—The Munich multicentric enterococci cohort”
Erratum for Rothe et al., “Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?—The Munich multicentric enterococci cohort” Open
View article: Comparative analysis of the clarus Aspergillus Galactomannan Enzyme Immunoassay for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid
Comparative analysis of the clarus Aspergillus Galactomannan Enzyme Immunoassay for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid Open
Background: Galactomannan (GM) testing using Platelia Aspergillus enzyme immunoassay (Platelia GM) from bronchoalveolar lavage fluid (BALF) aids in early diagnosis of invasive pulmonary aspergillosis (IPA). Globally, only a minority of lab…
View article: Toxic eburicol accumulation drives the antifungal activity of azoles against<i>Aspergillus fumigatus</i>
Toxic eburicol accumulation drives the antifungal activity of azoles against<i>Aspergillus fumigatus</i> Open
Azole antifungals inhibit the sterol C14-demethylase (CYP51/Erg11), a key enzyme in the ergosterol biosynthesis pathway. They have fungistatic effects against yeasts but fungicidal effects against molds. The molecular basis for this differ…
View article: Bacitracin agar vs. oleandomycin disk supplemented chocolate agar for the recovery of Haemophilus influenzae in diagnostic samples: A prospective comparison
Bacitracin agar vs. oleandomycin disk supplemented chocolate agar for the recovery of Haemophilus influenzae in diagnostic samples: A prospective comparison Open
Haemophilus influenzae is an important pathogen able to cause various forms of respiratory and invasive disease. To provide high sensitivity for detection, culture media must inhibit growth of residential flora from the respiratory tract. …
View article: 1032. Are enterococcal blood stream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness? - The Munich Multi-Centric Enterococci cohort
1032. Are enterococcal blood stream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness? - The Munich Multi-Centric Enterococci cohort Open
Background To assess the long-term survival of patients with enterococcal bloodstream infections (BSI), encompassing various species and resistance patterns, in comparison to Escherichia coli (E. coli) BSI. Recruitment process Graphical Ab…
View article: Head-to-Head Comparison of Nine Assays for the Detection of Anti-<i>Echinococcus</i> Antibodies: A Retrospective Evaluation
Head-to-Head Comparison of Nine Assays for the Detection of Anti-<i>Echinococcus</i> Antibodies: A Retrospective Evaluation Open
Echinococcus serological assays are highly variable in terms of sensitivity and specificity. Knowledge of the pre-test probability in the patient cohort is required to choose a suitable assay. A combined approach with screening and …
View article: Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?—The Munich multicentric enterococci cohort
Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?—The Munich multicentric enterococci cohort Open
To assess the long-term survival of patients with enterococcal bloodstream infections (BSI), encompassing various species and resistance patterns compared to Escherichia coli ( E. coli ) BSI. Between 2010–2019, 3,290 enterococcal and 3,415…
View article: A head-to-head comparison of three MALDI-TOF mass spectrometry systems with 16S rRNA gene sequencing
A head-to-head comparison of three MALDI-TOF mass spectrometry systems with 16S rRNA gene sequencing Open
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized diagnostics in culture-based microbiology. Commonly used MALDI-TOF MS systems in clinical microbiology laboratories are MALDI Bi…
View article: The Austrian landscape of diagnostic capacity and access to treatment for invasive fungal infections
The Austrian landscape of diagnostic capacity and access to treatment for invasive fungal infections Open
Introduction Immunosuppression after chemotherapy, stem cell transplantation or solid organ transplantation are the main risk factors for invasive fungal infections in Austria. Here, we aim to describe the status of laboratory mycology and…
View article: A retrospective evaluation of the Euroarray STI-11 multiplex system for the detection of eight STI causing agents
A retrospective evaluation of the Euroarray STI-11 multiplex system for the detection of eight STI causing agents Open
View article: Performance of galactomannan testing from endotracheal aspirate to guide bronchoalveolar lavage in the diagnosis of invasive aspergillosis
Performance of galactomannan testing from endotracheal aspirate to guide bronchoalveolar lavage in the diagnosis of invasive aspergillosis Open
Purpose Invasive aspergillosis is a major threat to immunocompromised individuals. Galactomannan (GM) is used as a biomarker for invasive aspergillosis. Investigations recommended in current guidelines include GM testing of bronchoalveolar…
View article: Rapid point of care testing for four bacterial sexually transmitted infections using the portable isothermal loop-mediated nucleic acid amplification eazyplex platform
Rapid point of care testing for four bacterial sexually transmitted infections using the portable isothermal loop-mediated nucleic acid amplification eazyplex platform Open
View article: Are Enterococcal Bloodstream Infections an Independent Risk Factor for a Poorer 5-Year Survival or Just a Marker for Severity of Illness? - The Munich Multicentric Enterococci Cohort
Are Enterococcal Bloodstream Infections an Independent Risk Factor for a Poorer 5-Year Survival or Just a Marker for Severity of Illness? - The Munich Multicentric Enterococci Cohort Open
View article: Rapid Point of Care Testing for Sexually Transmitted Infections Using a Portable Isothermal Loop Mediated Nucleic Acid Amplification Platform
Rapid Point of Care Testing for Sexually Transmitted Infections Using a Portable Isothermal Loop Mediated Nucleic Acid Amplification Platform Open
Purpose To analyze sensitivity and specificity of the rapid point-of-care (POC) eazyplex STD complete testing platform for sexually transmitted infections (STI) among men who have sex with men (MSM). Methods 272 anal, urethral, and pharyng…
View article: Performance of Multiplex PCR and β-1,3-D-Glucan Testing for the Diagnosis of Candidemia
Performance of Multiplex PCR and β-1,3-D-Glucan Testing for the Diagnosis of Candidemia Open
Bloodstream infections caused by Candida yeasts (candidemia) are associated with high morbidity and mortality. Diagnosis remains challenging, with the current gold standard—isolation from blood culture (BC)—being limited by low sensitivity…
View article: Molecular Epidemiology of Mycobacterium abscessus Isolates Recovered from German Cystic Fibrosis Patients
Molecular Epidemiology of Mycobacterium abscessus Isolates Recovered from German Cystic Fibrosis Patients Open
Mycobacterium abscessus is a major respiratory pathogen in cystic fibrosis (CF) patients. Recently it has been shown that dominant global clonal complexes (DCCs) have spread worldwide among CF patients.
View article: Serologic biomarkers in <i>Candida</i> and <i>Aspergillus</i> infections of the central nervous system: A comparison of galactomannan, mannan and β‐1,<scp>3‐D</scp>‐gucan testing from serum and cerebrospinal fluid
Serologic biomarkers in <i>Candida</i> and <i>Aspergillus</i> infections of the central nervous system: A comparison of galactomannan, mannan and β‐1,<span>3‐D</span>‐gucan testing from serum and cerebrospinal fluid Open
Background The incidence of Aspergillus and Candida CNS infection, which are characterised by high mortality rates, is underestimated. This underdiagnosis presumably results from the limitations of available diagnostic tools and the need f…
View article: Performance of the Euroimmun Aspergillus Antigen ELISA for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid
Performance of the Euroimmun Aspergillus Antigen ELISA for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid Open
Invasive pulmonary aspergillosis (IPA) is a life-threatening disease that affects mainly immunocompromised hosts. Galactomannan testing from serum and bronchoalveolar lavage fluid (BALF) represents a cornerstone in diagnosing the disease.