Karl E. Bauer
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View article: RNA supply drives physiological granule assembly in neurons
RNA supply drives physiological granule assembly in neurons Open
Membraneless cytoplasmic condensates of mRNAs and proteins, known as RNA granules, play pivotal roles in the regulation of mRNA fate. Their maintenance fine-tunes time and location of protein expression, affecting many cellular processes, …
View article: RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons
RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons Open
RNA-binding proteins (RBPs) act as posttranscriptional regulators controlling the fate of target mRNAs. Unraveling how RNAs are recognized by RBPs and in turn are assembled into neuronal RNA granules is therefore key to understanding the u…
View article: Pumilio2 and Staufen2 selectively balance the synaptic proteome
Pumilio2 and Staufen2 selectively balance the synaptic proteome Open
Neurons have the capacity to adapt to environmental stimuli, a phenomenon termed cellular plasticity. The underlying processes are controlled by a network of RNA-binding proteins (RBPs). Their precise impact, however, is largely unknown. T…
View article: Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses
Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses Open
mRNA transport restricts translation to specific subcellular locations, which is the basis for many cellular functions. However, the precise process of mRNA sorting to synapses in neurons remains elusive. Here we use Rgs4 mRNA to investiga…